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View article: Can plitidepsin be used as an antiviral against RSV?
Can plitidepsin be used as an antiviral against RSV? Open
Human respiratory syncytial virus (HRSV) is a main cause of acute lower respiratory tract infections in infants, the elderly, and immunocompromised patients. Although vaccines have recently been approved for the elderly and for pregnant wo…
View article: A dual interaction between RSV NS1 and MED25 ACID domain reshapes antiviral responses
A dual interaction between RSV NS1 and MED25 ACID domain reshapes antiviral responses Open
Respiratory syncytial virus (RSV), the most common cause of bronchiolitis and pneumonia in infants, elicits a remarkably weak innate immune response. This is partly due to type I interferon (IFN) antagonism by the non-structural RSV NS1 pr…
View article: Can Plitidepsin Be Used as an Antiviral Against RSV?
Can Plitidepsin Be Used as an Antiviral Against RSV? Open
Human respiratory syncytial virus (HRSV) is a main cause of acute lower respiratory tract infections in infants, the elderly and the immunocompromised patients. Although vaccines have recently been approved for the elderly and for pregnant…
View article: A dual interaction between RSV NS1 and MED25 ACID domain reshapes antiviral responses
A dual interaction between RSV NS1 and MED25 ACID domain reshapes antiviral responses Open
Respiratory syncytial virus (RSV), the most common cause of bronchiolitis and pneumonia in infants, elicits a remarkably weak innate immune response. This is partly due to the type I interferon (IFN-I) antagonism of the non-structural RSV …
View article: A New Derivative of Retro-2 Displays Antiviral Activity against Respiratory Syncytial Virus
A New Derivative of Retro-2 Displays Antiviral Activity against Respiratory Syncytial Virus Open
Human respiratory syncytial virus (hRSV) is the most common cause of bronchiolitis and pneumonia in newborns, with all children being infected before the age of two. Reinfections are very common throughout life and can cause severe respira…
View article: A New Derivative of Retro-2 Displays Antiviral Activity against Respiratory Syncytial Virus
A New Derivative of Retro-2 Displays Antiviral Activity against Respiratory Syncytial Virus Open
Human respiratory syncytial virus (hRSV) is the most common cause of bronchiolitis and pneumonia in new-borns, with all children being infected before the age of two. Reinfections are very common throughout life, and can cause severe respi…
View article: Hardening of Respiratory Syncytial Virus Inclusion Bodies by Cyclopamine Proceeds through Perturbation of the Interactions of the M2-1 Protein with RNA and the P Protein
Hardening of Respiratory Syncytial Virus Inclusion Bodies by Cyclopamine Proceeds through Perturbation of the Interactions of the M2-1 Protein with RNA and the P Protein Open
Respiratory syncytial virus (RSV) RNA synthesis takes place in cytoplasmic viral factories also called inclusion bodies (IBs), which are membrane-less organelles concentrating the viral RNA polymerase complex. The assembly of IBs is driven…
View article: Hardening of Respiratory Syncytial Virus Inclusion Bodies by Cyclopamine Proceeds through Perturbation of the Interactions between the M2-1 Protein, RNA and the P Protein
Hardening of Respiratory Syncytial Virus Inclusion Bodies by Cyclopamine Proceeds through Perturbation of the Interactions between the M2-1 Protein, RNA and the P Protein Open
Respiratory syncytial virus (RSV) RNA synthesis takes place in cytoplasmic viral factories also called inclusion bodies (IBs), which are membrane-less organelles concentrating the viral RNA polymerase complex. IBs assembly is driven by liq…
View article: Structure of the N-RNA/P interface reveals mode of L/P attachment to the nucleocapsid of human metapneumovirus
Structure of the N-RNA/P interface reveals mode of L/P attachment to the nucleocapsid of human metapneumovirus Open
Human metapneumovirus (HMPV) is a major cause of respiratory illness in young children. The polymerase complex of HMPV consists of two obligate components, the L polymerase and its cofactor, the phosphoprotein P. During replication and tra…
View article: Depletion of TAX1BP1 Amplifies Innate Immune Responses during Respiratory Syncytial Virus Infection
Depletion of TAX1BP1 Amplifies Innate Immune Responses during Respiratory Syncytial Virus Infection Open
Respiratory syncytial virus (RSV), which is the leading cause of lower respiratory tract illness in infants, remains a medical problem in the absence of a vaccine or efficient treatment. This virus is also recognized as a main pathogen in …
View article: Depletion of TAX1BP1 amplifies innate immune responses during respiratory syncytial virus infection
Depletion of TAX1BP1 amplifies innate immune responses during respiratory syncytial virus infection Open
Respiratory syncytial virus (RSV) is the main cause of acute respiratory infections in young children, and also has a major impact in the elderly and immunocompromised people. In the absence of vaccine or efficient treatment, a better unde…
View article: Characterization of the interaction domains between the phosphoprotein and the nucleocapsid of human Metapneumovirus
Characterization of the interaction domains between the phosphoprotein and the nucleocapsid of human Metapneumovirus Open
Human metapneumovirus (HMPV) causes severe respiratory diseases in young children. The HMPV RNA genome is encapsidated by the viral nucleoprotein, forming an RNA-N complex (N Nuc ), which serves as template for genome replication and mRNA …
View article: Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies <i>In Vivo</i> and <i>In Vitro</i>
Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies <i>In Vivo</i> and <i>In Vitro</i> Open
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract illness in infants, elderly, and immunocompromised people. No vaccine or efficient antiviral treatment is available against this virus. The replication and t…
View article: Biochemical characterization of the respiratory syncytial virus N0-P complex in solution
Biochemical characterization of the respiratory syncytial virus N0-P complex in solution Open
As all the viruses belonging to the Mononegavirales order, the nonsegmented negative-strand RNA genome of respiratory syncytial virus (RSV) is encapsidated by the viral nucleoprotein N. N protein polymerizes along the genomic and anti-geno…
View article: RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription
RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription Open
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in which all the components of the viral RNA polymerase are concentrated. In this work, we show that RSV P protein recruits the essential RSV tran…
View article: New Insights into Structural Disorder in Human Respiratory Syncytial Virus Phosphoprotein and Implications for Binding of Protein Partners
New Insights into Structural Disorder in Human Respiratory Syncytial Virus Phosphoprotein and Implications for Binding of Protein Partners Open
Phosphoprotein is the main cofactor of the viral RNA polymerase of Mononegavirales It is involved in multiple interactions that are essential for the polymerase function. Most prominently it positions the polymerase complex onto the nucleo…
View article: A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus
A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus Open
Presently, respiratory syncytial virus (RSV), the main cause of severe respiratory infections in infants, cannot be treated efficiently with antivirals. However, its RNA-dependent polymerase complex offers potential targets for RSV-specifi…
View article: Identification and Characterization of the Binding Site of the Respiratory Syncytial Virus Phosphoprotein to RNA-Free Nucleoprotein
Identification and Characterization of the Binding Site of the Respiratory Syncytial Virus Phosphoprotein to RNA-Free Nucleoprotein Open
The RNA genome of respiratory syncytial virus (RSV) is constitutively encapsidated by the viral nucleoprotein N, thus forming a helical nucleocapsid. Polymerization of N along the genomic and antigenomic RNAs is concomitant to replication …