Jenna Kropp Schmidt
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View article: Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque
Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque Open
Nanoparticles offer promise as a mechanism to non-invasively deliver targeted placental therapeutics. Our previous studies utilizing intraplacental administration demonstrate efficient nanoparticle uptake into placental trophoblast cells a…
View article: Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification
Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that bone morphogenetic protein (BMP) signal…
View article: Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Reviewer #2 (Public Review): Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Reviewer #2 (Public Review): Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Author response: Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Author response: Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Reviewer #3 (Public Review): Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Reviewer #3 (Public Review): Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque
Nanoparticle-mediated delivery of placental gene therapy via uterine artery catheterization in a pregnant rhesus macaque Open
Nanoparticles offer promise as a mechanism to non-invasively deliver targeted placental therapeutics. Our previous studies utilizing intraplacental administration demonstrate efficient nanoparticle uptake into placental trophoblast cells a…
View article: Whole Genome Analysis of SNV and Indel Polymorphism in Common Marmosets (Callithrix jacchus)
Whole Genome Analysis of SNV and Indel Polymorphism in Common Marmosets (Callithrix jacchus) Open
The common marmoset (Callithrix jacchus) is one of the most widely used nonhuman primate models of human disease. Owing to limitations in sequencing technology, early genome assemblies of this species using short-read sequencing suffered f…
View article: Atypical initial cleavage patterns minimally impact rhesus macaque in vitro embryo morphokinetics and embryo outgrowth development
Atypical initial cleavage patterns minimally impact rhesus macaque in vitro embryo morphokinetics and embryo outgrowth development Open
Embryo morphokinetic analysis through time-lapse embryo imaging is envisioned as a method to improve selection of developmentally competent embryos. Morphokinetic analysis could be utilized to evaluate the effects of experimental manipulat…
View article: Temporally resolved single cell transcriptomics in a human model of amniogenesis
Temporally resolved single cell transcriptomics in a human model of amniogenesis Open
Amniogenesis is triggered in a collection of pluripotent epiblast cells as the human embryo implants. To gain insights into the critical but poorly understood transcriptional machinery governing amnion fate determination, we examined the e…
View article: Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification
Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that bone morphogenetic protein (BMP) signal…
View article: Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primates
Maternal, placental and fetal response to a non-viral, polymeric nanoparticle gene therapy in nonhuman primates Open
Background Currently, there are no placenta-targeted treatments to alter the in utero environment. Water-soluble polymers have a distinguished record of clinical relevance outside of pregnancy. We have demonstrated the effective delivery o…
View article: Temporally resolved early BMP-driven transcriptional cascade during human amnion specification
Temporally resolved early BMP-driven transcriptional cascade during human amnion specification Open
Amniogenesis, a process critical for continuation of healthy pregnancy, is triggered in a collection of pluripotent epiblast cells as the human embryo implants. Previous studies have established that BMP signaling is a major driver of this…
View article: Whole genome sequencing of CCR5 CRISPR-Cas9-edited Mauritian cynomolgus macaque blastomeres reveals large-scale deletions and off-target edits
Whole genome sequencing of CCR5 CRISPR-Cas9-edited Mauritian cynomolgus macaque blastomeres reveals large-scale deletions and off-target edits Open
Introduction: Genome editing by CRISPR-Cas9 approaches offers promise for introducing or correcting disease-associated mutations for research and clinical applications. Nonhuman primates are physiologically closer to humans than other labo…
View article: CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection Open
Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technolog…
View article: Modeling genetic diseases in nonhuman primates through embryonic and germline modification: Considerations and challenges
Modeling genetic diseases in nonhuman primates through embryonic and germline modification: Considerations and challenges Open
Genetic modification of the embryo or germ line of nonhuman primates is envisioned as a method to develop improved models of human disease, yet the promise of such animal models remains unfulfilled. Here, we discuss current methods and the…
View article: Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts
Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts Open
Zika virus (ZIKV) infection at the maternal-placental interface is associated with adverse pregnancy outcomes including fetal demise and pregnancy loss. To determine how infection impacts placental trophoblasts, we utilized rhesus macaque …
View article: Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts
Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts Open
Zika virus (ZIKV) infection at the maternal-placental interface is associated with adverse pregnancy outcomes including fetal demise and pregnancy loss. To determine how infection impacts placental trophoblasts, we utilized rhesus macaque …
View article: Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts
Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts Open
Zika virus (ZIKV) infection at the maternal-placental interface is associated with adverse pregnancy outcomes including fetal demise and pregnancy loss. To determine how infection impacts placental trophoblasts, we utilized rhesus macaque …
View article: Comparative computer‐assisted sperm analysis in non‐human primates
Comparative computer‐assisted sperm analysis in non‐human primates Open
Background Biomedical research has recently focused on developing new models of human disease by implementing genome‐editing strategies in non‐human primates (NHPs) to introduce relevant gene mutations. There is a need to establish objecti…
View article: Placenta-derived macaque trophoblast stem cells: differentiation to syncytiotrophoblasts and extravillous trophoblasts reveals phenotypic reprogramming
Placenta-derived macaque trophoblast stem cells: differentiation to syncytiotrophoblasts and extravillous trophoblasts reveals phenotypic reprogramming Open
Nonhuman primates are excellent models for studying human placentation as experimental manipulations in vitro can be translated to in vivo pregnancy. Our objective was to develop macaque trophoblast stem cells (TSCs) as an in vitro platfor…
View article: Genome editing of CCR5 by CRISPR-Cas9 in Mauritian cynomolgus macaque embryos
Genome editing of CCR5 by CRISPR-Cas9 in Mauritian cynomolgus macaque embryos Open
The discovery that CCR5 serves as an R5-HIV-1 co-receptor, coupled with findings of protection from HIV infection in individuals lacking CCR5, led to the exploration of novel therapeutic strategies for HIV infection based on genome editing…
View article: Cryopreservation of Mauritian Cynomolgus Macaque (<i>Macaca fascicularis</i>) Sperm in Chemically Defined Medium
Cryopreservation of Mauritian Cynomolgus Macaque (<i>Macaca fascicularis</i>) Sperm in Chemically Defined Medium Open
The objective of this study was to optimize cryopreservation of sperm from Mauritian cynomolgus macaques (MCM) in defined conditions. Sperm viability and motility were compared between sperm cryopreserved in chemically-defined freezing med…
View article: The promise of placental extracellular vesicles: models and challenges for diagnosing placental dysfunction in utero†
The promise of placental extracellular vesicles: models and challenges for diagnosing placental dysfunction in utero† Open
Monitoring the health of a pregnancy is of utmost importance to both the fetus and the mother. The diagnosis of pregnancy complications typically occurs after the manifestation of symptoms, and limited preventative measures or effective tr…