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View article: Stem cell-derived heterocellular atrial engineered cardiac tissue with comparisons to native human atrial myocardium
Stem cell-derived heterocellular atrial engineered cardiac tissue with comparisons to native human atrial myocardium Open
We demonstrate an atrial-like engineered cardiac tissue that recapitulates adult human atrial contraction for both kinetics and force production. Furthermore, we include numerous previously unmeasured ultrastructure metrics such as sarcome…
View article: Proper Utilization of the National Inpatient Sample Database to Analyze Safety of Cardiovascular Procedures
Proper Utilization of the National Inpatient Sample Database to Analyze Safety of Cardiovascular Procedures Open
Importance Analysis of the National Inpatient Sample (NIS) database for the procedural safety of interventions that are primarily outpatient in nature can be inherently biased due to the selective hospitalization of patients who suffer com…
View article: Tracking progression of aortic stenosis with echocardiography
Tracking progression of aortic stenosis with echocardiography Open
Background Transthoracic echocardiography (TTE) is used to assess aortic stenosis (AS) severity and track disease progression. As the field moves to study medical therapies to halt disease progression, reliable non-invasive imaging markers…
View article: Perineural immune environment of olfactory nerves is reshaped by neuroinflammatory drainage and connects to ethmoid bone marrow
Perineural immune environment of olfactory nerves is reshaped by neuroinflammatory drainage and connects to ethmoid bone marrow Open
Cerebrospinal fluid (CSF) contains inflammatory cues that enable peripheral immune surveillance of the central nervous system (CNS). While some cranial nerves allow for CSF efflux, the immune environment around CSF-interfacing cranial nerv…
View article: Dual role of vascular endothelial growth factor-C in post-stroke recovery
Dual role of vascular endothelial growth factor-C in post-stroke recovery Open
Cerebrospinal fluid (CSF), antigens, and antigen-presenting cells drain from the central nervous system (CNS) into lymphatic vessels near the cribriform plate and dura, yet the role of these vessels during stroke is unclear. Using a mouse …
View article: A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene
A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene Open
Previously we showed the generation of a protein trap library made with the gene-break transposon (GBT) in zebrafish ( Danio rerio ) that could be used to facilitate novel functional genome annotation towards understanding molecular underp…