Jenni Hällfors
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View article: A population-based registry study on psoriasis-associated burden of disease in Finland
A population-based registry study on psoriasis-associated burden of disease in Finland Open
Introduction Despite advancements in treatment, unmet needs persist for patients with plaque psoriasis (PSO). This study characterized PSO patients who were initiating or switching biologic medications, with or without prior biologic use, …
View article: The burden of chronic rhinosinusitis with nasal polyps and its relation to asthma in Finland
The burden of chronic rhinosinusitis with nasal polyps and its relation to asthma in Finland Open
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is commonly associated with asthma. Treatment of CRSwNP includes intranasal and systemic corticosteroids, with non‐responsive patients commonly considered for endoscopic sinus su…
View article: Cardiovascular outcome according to renal status in Finnish patients with type 2 diabetes
Cardiovascular outcome according to renal status in Finnish patients with type 2 diabetes Open
Background: : Type 2 diabetes (T2DM) increases the risk for chronic kidney disease (CKD). The objective of this study was to describe the characteristics of patients with T2DM and assess their cardiovascular (CV) and renal outcomes as well…
View article: The burden of Chronic Rhinosinusitis with Nasal Polyps and its relation to Asthma in Finland
The burden of Chronic Rhinosinusitis with Nasal Polyps and its relation to Asthma in Finland Open
Background : Chronic rhinosinusitis with nasal polyps (CRSwNP) is commonly associated with asthma. Treatment of CRSwNP includes intranasal and systemic corticosteroids, with non-responsive patients commonly considered for endoscopic sinus …
View article: Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes
Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes Open
Introduction FTND (Fagerstrӧm test for nicotine dependence) and TTFC (time to smoke first cigarette in the morning) are common measures of nicotine dependence (ND). However, genome-wide meta-analysis for these phenotypes has not been repor…
View article: Metabolomic Signature of Angiopoietin-Like Protein 3 Deficiency in Fasting and Postprandial State
Metabolomic Signature of Angiopoietin-Like Protein 3 Deficiency in Fasting and Postprandial State Open
Objective— Loss-of-function (LOF) variants in the ANGPTL3 (angiopoietin-like protein 3) have been associated with low levels of plasma lipoproteins and decreased coronary artery disease risk. We aimed to determine detailed metabolic effect…
View article: Metabolomic signature of angiopoietin-like protein 3 deficiency in fasting and postprandial state
Metabolomic signature of angiopoietin-like protein 3 deficiency in fasting and postprandial state Open
Objective Loss-of-function variants in the angiopoietin-like 3 gene ( ANGPTL3 ) have been associated with low levels of plasma lipoproteins and decreased coronary artery disease risk. We aimed to determine detailed metabolic effects of gen…
View article: Is Brain Derived Neurotrophic Factor (Bdnf) Associated With Smoking Initiation? Replication Using a Large Finnish Population Sample
Is Brain Derived Neurotrophic Factor (Bdnf) Associated With Smoking Initiation? Replication Using a Large Finnish Population Sample Open
Earlier finding about the association between the BDNF gene and smoking initiation is replicated and shown to be independent of depression within Finnish adult population.
View article: Genome‐wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway
Genome‐wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway Open
The heritability of nicotine dependence based on family studies is substantial. Nevertheless, knowledge of the underlying genetic architecture remains meager. Our aim was to identify novel genetic variants responsible for interindividual d…
View article: Nicotine Dependence : Identifying the Contribution of Specific Genes
Nicotine Dependence : Identifying the Contribution of Specific Genes Open
Cigarette smoking is a worldwide health burden causing several diseases. Chronic obstructive pulmonary disease, heart disease and several cancers remain the main avoidable causes for premature deaths. Among smokers, tobacco use is largely …
View article: <i>KLB</i> is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
<i>KLB</i> is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference Open
Significance Alcohol is a widely consumed drug in western societies that can lead to addiction. A small shift in consumption can have dramatic consequences on public health. We performed the largest genome-wide association metaanalysis and…