Jenni Virta
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View article: Longitudinal monitoring of nanofibrillar cellulose hydrogel medical implants in mice using positron emission tomography
Longitudinal monitoring of nanofibrillar cellulose hydrogel medical implants in mice using positron emission tomography Open
Nanofibrillar cellulose (NFC) hydrogel has emerged as a promising implantable material for therapeutic applications. In this study, the relatively longer-lived positron-emitting radionuclide zirconium-89 was chelated to the octadentate def…
View article: Single-cell to pre-clinical evaluation of <i>Trem2</i> , <i>Folr2</i> , and <i>Slc7a7</i> as macrophage-associated biomarkers for atherosclerosis
Single-cell to pre-clinical evaluation of <i>Trem2</i> , <i>Folr2</i> , and <i>Slc7a7</i> as macrophage-associated biomarkers for atherosclerosis Open
Aims Atherosclerosis is a major global health challenge, with limited diagnostic and therapeutic options. Macrophages drive disease progression, but their tissue-specific phenotypes and functions remain poorly defined. This study aims to e…
View article: MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution
MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution Open
Background Regulatory networks controlling aging and disease trajectories remain incompletely understood. MicroRNAs (miRNAs) are a class of regulatory non-coding RNAs that contribute to the regulation of tissue homeostasis by modulating th…
View article: Comparing Two Folate Receptor β-Targeted Tracers in a Rat Model of Experimental Autoimmune Myocarditis
Comparing Two Folate Receptor β-Targeted Tracers in a Rat Model of Experimental Autoimmune Myocarditis Open
Folate receptor β (FR-β) expression may serve as a marker of activated macrophages involved in autoimmune myocarditis. The positron emission tomography (PET) tracer N-succinimidyl 4-[18F]-fluorobenzoate-conjugated folate ([18F]-SFB-FOL) ef…
View article: Detection of Intestinal Inflammation by Vascular Adhesion Protein-1-Targeted [68Ga]Ga-DOTA-Siglec-9 Positron Emission Tomography in Murine Models of Inflammatory Bowel Disease
Detection of Intestinal Inflammation by Vascular Adhesion Protein-1-Targeted [68Ga]Ga-DOTA-Siglec-9 Positron Emission Tomography in Murine Models of Inflammatory Bowel Disease Open
Purpose Inflammatory bowel disease (IBD) can be imaged with positron emission tomography (PET), but existing PET radiopharmaceuticals have limited diagnostic accuracy. Vascular adhesion protein-1 (VAP-1) is an endothelial cell surface mole…
View article: Cell-type-specific characterization of miRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution
Cell-type-specific characterization of miRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution Open
MicroRNAs (miRNAs) are a class of regulatory non-coding RNAs that finetune cellular functions by modulating the stability and abundance of their target mRNAs, thereby contributing to regulation of tissue homeostasis. MiRNA genes are transc…
View article: Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis
Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis Open
VAP-1-targeted [68Ga]Ga-DOTA-Siglec-9 PET is a potential novel technique for the detection of myocardial lesions.
View article: High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities
High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilities Open
Introduction Non-invasive imaging techniques such as positron emission tomography (PET) are extremely important for cancer detection and characterization especially for difficult to biopsy or extremely delicate organs such as the brain. Th…
View article: Preclinical Evaluation of<sup>89</sup>Zr-Desferrioxamine-Bexmarilimab, a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1, in a Rabbit Model of Renal Fibrosis
Preclinical Evaluation of<sup>89</sup>Zr-Desferrioxamine-Bexmarilimab, a Humanized Antibody Against Common Lymphatic Endothelial and Vascular Endothelial Receptor-1, in a Rabbit Model of Renal Fibrosis Open
Bexmarilimab is a new humanized monoclonal antibody against common lymphatic endothelial and vascular endothelial receptor-1 (CLEVER-1) and is in clinical trials for macrophage-guided cancer immunotherapy. In addition being associated with…
View article: Exploring macrophage mannose receptor expression after myocardial infarction by Al[18F]F-NOTA-DCM positron emission tomography
Exploring macrophage mannose receptor expression after myocardial infarction by Al[18F]F-NOTA-DCM positron emission tomography Open
Introduction Mannose receptor (CD206) is primarily expressed on the surface of alternatively activated macrophages that are involved in resolution of inflammation after myocardial injury [1]. The purpose of this study was to evaluate manno…
View article: [11C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue
[11C]carfentanil PET imaging for studying the peripheral opioid system in vivo: effect of photoperiod on mu-opioid receptor availability in brown adipose tissue Open
Purpose Photoperiod determines the metabolic activity of brown adipose tissue (BAT) and affects the food intake and body mass of mammals. Sympathetic innervation of the BAT controls thermogenesis and facilitates physiological adaption to s…
View article: Dissecting the polygenic basis of atherosclerosis using disease associated cell state signatures
Dissecting the polygenic basis of atherosclerosis using disease associated cell state signatures Open
Coronary artery disease (CAD) is a pandemic disease where up to half of the risk is explained by genetic factors. Advanced insights into genetic basis of CAD require deeper understanding of the contributions of different cell types, molecu…
View article: Corrigendum: Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine
Corrigendum: Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine Open
[This corrects the article DOI: 10.3389/fimmu.2022.821423.].
View article: Photoperiod modulates mu-opioid receptor availability in brown adipose tissue
Photoperiod modulates mu-opioid receptor availability in brown adipose tissue Open
Photoperiod drives metabolic activity of brown adipose tissue (BAT), and affects food intake and weight gain in mammals. Sympathetic innervation in BAT controls thermogenesis and facilitates physiological adaption to seasons, but the exact…
View article: Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine
Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine Open
Increased glutamine metabolism by macrophages is associated with development of atherosclerotic lesions. Positron emission tomography/computed tomography (PET/CT) with a glutamine analog (2S,4 R )-4- 18 F-fluoroglutamine ( 18 F-FGln) allow…
View article: Evaluation of [68Ga]Ga-NODAGA-RGD for PET Imaging of Rat Autoimmune Myocarditis
Evaluation of [68Ga]Ga-NODAGA-RGD for PET Imaging of Rat Autoimmune Myocarditis Open
The 68 Gallium-labeled 1,4,7-triazacyclononane-1-glutaric acid-4,7-diacetic acid conjugated radiolabelled arginine-glycine-aspartic acid peptide ([ 68 Ga]Ga-NODAGA-RGD) is a positron emission tomography (PET) tracer binding to cell surface…
View article: Comparison of: (2S,4R)-4-[18F]Fluoroglutamine, [11C]Methionine, and 2-Deoxy-2-[18F]Fluoro-D-Glucose and Two Small-Animal PET/CT Systems Imaging Rat Gliomas
Comparison of: (2S,4R)-4-[18F]Fluoroglutamine, [11C]Methionine, and 2-Deoxy-2-[18F]Fluoro-D-Glucose and Two Small-Animal PET/CT Systems Imaging Rat Gliomas Open
Purpose The three positron emission tomography (PET) imaging compounds: (2 S ,4 R )-4-[ 18 F]Fluoroglutamine ([ 18 F]FGln), L -[methyl- 11 C]Methionine ([ 11 C]Met), and 2-deoxy-2-[ 18 F]fluoro- D -glucose ([ 18 F]FDG) were investigated to…
View article: Seasonal Variation in the Brain μ-Opioid Receptor Availability
Seasonal Variation in the Brain μ-Opioid Receptor Availability Open
Seasonal rhythms influence mood and sociability. The brain μ-opioid receptor (MOR) system modulates a multitude of seasonally varying socioemotional functions, but its seasonal variation remains elusive with no previously reported in vivo …
View article: Seasonal variation in brain mu-opioid receptor availability
Seasonal variation in brain mu-opioid receptor availability Open
Seasonal rhythms influence mood and sociability. The brain μ-opioid receptor (MOR) system modulates a multitude of seasonally varying socioemotional functions, but its seasonal variation remains elusive with no previously reported in vivo …
View article: Radiosynthesis and Preclinical Evaluation of [<sup>68</sup>Ga]Ga-NOTA-Folate for PET Imaging of Folate Receptor β Positive Macrophages
Radiosynthesis and Preclinical Evaluation of [<sup>68</sup>Ga]Ga-NOTA-Folate for PET Imaging of Folate Receptor β Positive Macrophages Open
Folate receptor β (FR-β) is one of the markers expressed on macrophages and a promising target for imaging of inflammation. Here, we report the radiosynthesis and preclinical evaluation of [ 68 Ga]Ga-NOTA-folate ( 68 Ga-FOL). First, we det…
View article: Folate Receptor β–Targeted PET Imaging of Macrophages in Autoimmune Myocarditis
Folate Receptor β–Targeted PET Imaging of Macrophages in Autoimmune Myocarditis Open
Currently available imaging techniques have limited specificity for the detection of active myocardial inflammation. Aluminum 18F-labeled 1,4,7-triazacyclononane-N,N',N″-triacetic acid conjugated folate (18F-FOL) is a PET tracer targeting …