Jennifer A. Macdonald
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View article: Seeding biosensor cell line that reproduces the Alzheimer tau fold
Seeding biosensor cell line that reproduces the Alzheimer tau fold Open
The assembly of tau protein into amyloid filaments through templated seeding is believed to underlie the propagation of pathology in neurodegenerative diseases, such as Alzheimer's disease (AD) and other tauopathies. A commonly used model …
View article: Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau Open
View article: Cryo-EM structures of Tau filaments from the brains of mice transgenic for human mutant P301S Tau
Cryo-EM structures of Tau filaments from the brains of mice transgenic for human mutant P301S Tau Open
Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions made of human mutant four-repeat tau. Here we used electron cryo-microscopy (cry…
View article: Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains Open
View article: Cryo-EM Structures of Amyloid-β Filaments With the Arctic Mutation (E22G) From Human and Mouse Brains
Cryo-EM Structures of Amyloid-β Filaments With the Arctic Mutation (E22G) From Human and Mouse Brains Open
The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited Alzheimer’s disease. Here we report the high-resolution cryo-EM structures of Aβ filaments from the front…
View article: Increase in Tau Pathology in P290S<i>Mapt</i>Knock-In Mice Crossed with<i>App</i><sup>NL-G-F</sup>Mice
Increase in Tau Pathology in P290S<i>Mapt</i>Knock-In Mice Crossed with<i>App</i><sup>NL-G-F</sup>Mice Open
Alzheimer’s Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. To investigate the link between Aβ and tau p…
View article: Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds Open
Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case when cereb…
View article: Cryo-EM Structures of Amyloid-β 42 Filaments from Human Brain
Cryo-EM Structures of Amyloid-β 42 Filaments from Human Brain Open
Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in Alzheimer’s disease. We report the cryo-EM structures of Aβ42 filaments from brain. Two structurally related S-shaped protofilament folds give rise t…
View article: Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models
Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models Open
Aggregated tau protein is a core pathology present in several neurodegenerative diseases. Therefore, the development and application of positron emission tomography (PET) imaging radiotracers that selectively bind to aggregated tau in fibr…
View article: Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy
Neuropathological changes and cognitive deficits in rats transgenic for human mutant tau recapitulate human tauopathy Open
The assembly of tau protein into abnormal filaments and brain cell degeneration are characteristic of a number of human neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromo…
View article: Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord
Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord Open
A pathological pathway leading from soluble monomeric to insoluble filamentous Tau is characteristic of many human neurodegenerative diseases, which also exhibit dysfunction and death of brain cells. However, it is unknown how the assembly…