Jennifer Arthur Ataam
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View article: Integrated phenotypic and transcriptomic characterization of desmin-related cardiomyopathy in hiPSC-derived cardiomyocytes and machine learning-based classification of disease features
Integrated phenotypic and transcriptomic characterization of desmin-related cardiomyopathy in hiPSC-derived cardiomyocytes and machine learning-based classification of disease features Open
Desmin-related diseases are characterized by skeletal muscle weakness, cardiomyopathy, and respiratory dysfunction due to mutations in the desmin gene (DES), which encodes a protein essential for muscle cell integrity. This study investiga…
View article: Artery-on-chip demonstrates smooth muscle function comparable to both healthy and diseased living tissues
Artery-on-chip demonstrates smooth muscle function comparable to both healthy and diseased living tissues Open
Arterial diseases affect the mechanical properties of blood vessels, which then alter their function via complex mechanisms. To develop and test effective treatments, microphysiological systems replicating the function and mechanics of a h…
View article: Generation of human induced pluripotent stem cell lines derived from four patients with a pathogenic ALPK3 variant associated with adult-onset hypertrophic cardiomyopathy (HCM)
Generation of human induced pluripotent stem cell lines derived from four patients with a pathogenic ALPK3 variant associated with adult-onset hypertrophic cardiomyopathy (HCM) Open
Loss of function variants in ALPK3 have been associated with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM). However, the underlying pathomechanism remain largely unknown. Here, we generated human iPSC lines from four H…
View article: Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy Open
Aims Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of DCM, the molecular mechanisms underlying the pathogenesis of familial DCM remain unknow…
View article: Targeting mAKAPβ expression as a therapeutic approach for ischemic cardiomyopathy
Targeting mAKAPβ expression as a therapeutic approach for ischemic cardiomyopathy Open
Ischemic cardiomyopathy is a leading cause of death and an unmet clinical need. Adeno-associated virus (AAV) gene-based therapies hold great promise for treating and preventing heart failure. Previously we showed that muscle A-kinase Ancho…
View article: Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy
Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy Open
Background: Phospholamban (PLN) is a critical regulator of calcium cycling and contractility in the heart. The loss of arginine at position 14 in PLN (R14del) is associated with dilated cardiomyopathy with a high prevalence of ventricular …
View article: Targeted proteomics of right heart adaptation to pulmonary arterial hypertension
Targeted proteomics of right heart adaptation to pulmonary arterial hypertension Open
No prior proteomic screening study has centred on the right ventricle (RV) in pulmonary arterial hypertension (PAH). This study investigates the circulating proteomic profile associated with right heart maladaptive phenotype (RHMP) in PAH.…
View article: Targeted Proteomics of Right Heart Adaptation to Pulmonary Arterial Hypertension
Targeted Proteomics of Right Heart Adaptation to Pulmonary Arterial Hypertension Open
Rationale No prior proteomic screening study has centered on the right ventricle (RV) in pulmonary arterial hypertension (PAH). Objectives To identify the circulating proteomic profile associated with right heart maladaptive phenotype (RHM…