Jennifer C. Dunn
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View article: Pharmacological modulation of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) EP receptors improves cardiomyocyte function under hyperglycemic conditions
Pharmacological modulation of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) EP receptors improves cardiomyocyte function under hyperglycemic conditions Open
Type 2 diabetes (T2D) affects >30 million Americans and nearly 70% of individuals with T2D will die from cardiovascular disease (CVD). Circulating levels of the inflammatory signaling lipid, prostaglandin E 2 (PGE 2 ), are elevated in the …
View article: Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage
Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage Open
View article: Critical Rhetoric| Critical Rhetoric in the Age of the (First) Reality TV President: A Critique of Freedom and Domination
Critical Rhetoric| Critical Rhetoric in the Age of the (First) Reality TV President: A Critique of Freedom and Domination Open
The purpose of this article is to examine Donald Trump’s tweets from a critical rhetorical orientation. This article suggests that the identity constructed in Trump’s tweets extends the persona he developed on the reality television series…
View article: Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition
Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition Open
View article: Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability
Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability Open
The transcription factors pancreatic and duodenal homeobox 1 (Pdx1) and onecut1 (Oc1) are coexpressed in multipotent pancreatic progenitors (MPCs), but their expression patterns diverge in hormone-expressing cells, with Oc1 expression bein…
View article: Vascular-derived connective tissue growth factor (Ctgf) is critical for pregnancy-induced β cell hyperplasia in adult mice
Vascular-derived connective tissue growth factor (Ctgf) is critical for pregnancy-induced β cell hyperplasia in adult mice Open
During pregnancy, maternal β cells undergo compensatory changes including hypertrophy, hyperplasia, and increased glucose-stimulated insulin secretion (GSIS). Failure of these adaptations to occur can result in gestational diabetes mellitu…
View article: Retraction
Retraction Open
View article: Unexpected effects of the MIP-Cre<sup>ER</sup>transgene and tamoxifen on<i>β</i>-cell growth in C57Bl6/J male mice
Unexpected effects of the MIP-Cre<sup>ER</sup>transgene and tamoxifen on<i>β</i>-cell growth in C57Bl6/J male mice Open
Transgenic mouse models have been fundamental in the discovery of factors that regulate β-cell development, mass, and function. Several groups have recently shown that some of these models display previously uncharacterized phenotypes due …
View article: Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice
Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice Open
During pregnancy, maternal β-cells undergo compensatory changes, including increased β-cell mass and enhanced glucose-stimulated insulin secretion. Failure of these adaptations to occur results in gestational diabetes mellitus. The secrete…
View article: Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion
Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion Open
Type 2 diabetes incidence increases with age, while β-cell replication declines. The transcription factor FoxM1 is required for β-cell replication in various situations, and its expression declines with age. We hypothesized that increased …
View article: Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury
Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury Open
View article: High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice
High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice Open
Both short- (1 wk) and long-term (2–12 mo) high-fat diet (HFD) studies reveal enhanced β-cell mass due to increased β-cell proliferation. β-Cell proliferation following HFD has been postulated to occur in response to insulin resistance; ho…