Ching Man Wai
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View article: IMMU-29. CSMD3 modulates the inflammatory induction of diffusely infiltrating low-grade gliomas in preclinical models
IMMU-29. CSMD3 modulates the inflammatory induction of diffusely infiltrating low-grade gliomas in preclinical models Open
Well-regulated inflammation can control tumors by enhancing immune surveillance and clearance. Paradoxically, chronic inflammation can be a central mediator for the initiation and progression of cancers. Using a clinically relevant genetic…
View article: Multi-site Assessment of Methods for Cell Preservation Upstream of Single Cell RNA Sequencing
Multi-site Assessment of Methods for Cell Preservation Upstream of Single Cell RNA Sequencing Open
Single cell RNA sequencing (scRNA-seq) is a revolutionary technique to identify cell types and their molecular phenotype in heterogeneous biological specimens. ScRNA-seq typically requires fresh, high quality single cell suspensions that a…
View article: Micropillar-induced changes in cell nucleus morphology enhance bone regeneration by modulating the secretome
Micropillar-induced changes in cell nucleus morphology enhance bone regeneration by modulating the secretome Open
Nuclear morphology, which modulates chromatin architecture, plays a critical role in regulating gene expression and cell functions. While most research has focused on the direct effects of nuclear morphology on cell fate, its impact on the…
View article: The genome and population genomics of allopolyploid Coffea arabica reveal the diversification history of modern coffee cultivars
The genome and population genomics of allopolyploid Coffea arabica reveal the diversification history of modern coffee cultivars Open
View article: Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation
Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation Open
While immunotherapy has revolutionized cancer treatment, its safety has been hampered by immunotherapy-related adverse events. Unexpectedly, we show that Mediator complex subunit 1 (MED1) is required for T regulatory (Treg) cell…
View article: Differential gene expression during floral transition in pineapple
Differential gene expression during floral transition in pineapple Open
Pineapple ( Ananas comosus var. comosus ) and ornamental bromeliads are commercially induced to flower by treatment with ethylene or its analogs. The apex is transformed from a vegetative to a floral meristem and shows morphological change…
View article: SAT355 Single-Cell RNA Sequencing Pipeline for the Human Ovary Using IVF Tissue
SAT355 Single-Cell RNA Sequencing Pipeline for the Human Ovary Using IVF Tissue Open
Disclosure: A.J. Hanson: None. S. Shah: None. C. Wai: None. R. Bauer: None. C. Boots: None. M. Urbanek: None. Objective: Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy of reproductive aged women, affecting 6-15% of wome…
View article: Cross-species predictive modeling reveals conserved drought responses between maize and sorghum
Cross-species predictive modeling reveals conserved drought responses between maize and sorghum Open
Drought tolerance is a highly complex trait controlled by numerous interconnected pathways with substantial variation within and across plant species. This complexity makes it difficult to distill individual genetic loci underlying toleran…
View article: Core cellular and tissue‐specific mechanisms enable desiccation tolerance in <i>Craterostigma</i>
Core cellular and tissue‐specific mechanisms enable desiccation tolerance in <i>Craterostigma</i> Open
SUMMARY Resurrection plants can survive prolonged life without water (anhydrobiosis) in regions with seasonal drying. This desiccation tolerance requires the coordination of numerous cellular processes across space and time, and individual…
View article: Mediator Complex Subunit 1 Promotes Differentiation and Function of a Tumor-Specific T Regulatory Cell Population
Mediator Complex Subunit 1 Promotes Differentiation and Function of a Tumor-Specific T Regulatory Cell Population Open
View article: Regulatory dynamics distinguishing desiccation tolerance strategies within resurrection grasses
Regulatory dynamics distinguishing desiccation tolerance strategies within resurrection grasses Open
Desiccation tolerance has evolved recurrently in grasses using two unique strategies of either protecting or dismantling the photosynthetic apparatus to minimize photooxidative damage under life without water (anhydrobiosis). Here, we surv…
View article: Pistachio genomes provide insights into nut tree domestication and ZW sex chromosome evolution
Pistachio genomes provide insights into nut tree domestication and ZW sex chromosome evolution Open
View article: Cross-species predictive modeling reveals conserved drought responses between maize and sorghum
Cross-species predictive modeling reveals conserved drought responses between maize and sorghum Open
Drought tolerance is a highly complex trait controlled by numerous interconnected pathways with substantial variation within and across plant species. This complexity makes it difficult to distill individual genetic loci underlying toleran…
View article: Taro raphide‐associated proteins: Allergens and crystal growth
Taro raphide‐associated proteins: Allergens and crystal growth Open
Calcium oxalate raphide crystals are found in bundles in intravacuolar membrane chambers of specialized idioblasts cells of most plant families. Aroid raphides are proposed to cause acridity in crops such as taro ( Colocasia esculenta (L.)…
View article: The complex octoploid Craterostigma genome and tissue-specific mechanisms underlying desiccation tolerance
The complex octoploid Craterostigma genome and tissue-specific mechanisms underlying desiccation tolerance Open
Resurrection plants can survive prolonged anhydrobiosis, and desiccation tolerance has evolved recurrently across land plants as a common adaptation for survival in regions with seasonal drying. Craterostigma plantagineum was among the fir…
View article: Two divergent haplotypes from a highly heterozygous lychee genome suggest independent domestication events for early and late-maturing cultivars
Two divergent haplotypes from a highly heterozygous lychee genome suggest independent domestication events for early and late-maturing cultivars Open
View article: Identification and analysis of stem‐specific promoters from sugarcane and energy cane for oil accumulation in their stems
Identification and analysis of stem‐specific promoters from sugarcane and energy cane for oil accumulation in their stems Open
Considerable recent progress has been achieved in bioengineering oil accumulation in the vegetative tissues of plants, opening an opportunity for large scale production of biodiesel, jet fuel, lubricants, and high‐value lipid bioproducts. …
View article: NDR1 and the Arabidopsis Plasma Membrane ATPase AHA5 are Required for Processes that Converge on Drought Tolerance and Immunity
NDR1 and the Arabidopsis Plasma Membrane ATPase AHA5 are Required for Processes that Converge on Drought Tolerance and Immunity Open
NON-RACE-SPECIFIC DISEASE RISISTANCE1 (NDR1) is a key component of plant immune signaling, required for defense against the bacterial pathogen Pseudomonas syringae . Plant stress responses have overlapping molecular, physiological, and cel…
View article: Transcriptional regulation of dosage compensation in Carica papaya
Transcriptional regulation of dosage compensation in Carica papaya Open
View article: Intertwined signatures of desiccation and drought tolerance in grasses
Intertwined signatures of desiccation and drought tolerance in grasses Open
Grasses are among the most resilient plants, and some can survive prolonged desiccation in semiarid regions with seasonal rainfall. However, the genetic elements that distinguish grasses that are sensitive versus tolerant to extreme drying…
View article: Exceptional subgenome stability and functional divergence in the allotetraploid Ethiopian cereal teff
Exceptional subgenome stability and functional divergence in the allotetraploid Ethiopian cereal teff Open
View article: The role of cis-elements in the evolution of crassulacean acid metabolism photosynthesis
The role of cis-elements in the evolution of crassulacean acid metabolism photosynthesis Open
Crassulacean acid metabolism (CAM) photosynthesis is an innovation of carbon concentrating mechanism that is characterized by nocturnal CO 2 fixation. Recent progresses in genomics, transcriptomics, proteomics, and metabolomics of CAM spec…
View article: <i>Fusarium virguliform</i><i>e</i> Transcriptional Plasticity Is Revealed by Host Colonization of Maize versus Soybean
<i>Fusarium virguliform</i><i>e</i> Transcriptional Plasticity Is Revealed by Host Colonization of Maize versus Soybean Open
We exploited the broad host range of Fusarium virguliforme to identify differential fungal responses leading to either an endophytic or a pathogenic lifestyle during colonization of maize (Zea mays) and soybean (Glycine ma…
View article: GingerRoot: A Novel DNA Transposon Encoding Integrase-Related Transposase in Plants and Animals
GingerRoot: A Novel DNA Transposon Encoding Integrase-Related Transposase in Plants and Animals Open
Transposable elements represent the largest components of many eukaryotic genomes and different genomes harbor different combinations of elements. Here, we discovered a novel DNA transposon in the genome of the clubmoss Selaginella lepidop…
View article: The bracteatus pineapple genome and domestication of clonally propagated crops
The bracteatus pineapple genome and domestication of clonally propagated crops Open
Domestication of clonally propagated crops such as pineapple from South America was hypothesized to be a ‘one-step operation’. We sequenced the genome of Ananas comosus var. bracteatus CB5 and assembled 513 Mb into 25 chromosomes with 29,4…
View article: Time of day and network reprogramming during drought induced CAM photosynthesis in Sedum album
Time of day and network reprogramming during drought induced CAM photosynthesis in Sedum album Open
Plants with facultative crassulacean acid metabolism (CAM) maximize performance through utilizing C3 or C4 photosynthesis under ideal conditions while temporally switching to CAM under water stress (drought). While genome-scale analyses of…
View article: Intertwined signatures of desiccation and drought tolerance in grasses
Intertwined signatures of desiccation and drought tolerance in grasses Open
Grasses are among the most resilient plants and some can survive prolonged desiccation in semi-arid regions with seasonal rainfall. This vegetative desiccation tolerance has arisen independently multiple times within the grass family, but …
View article: Arabidopsis defense mutant ndr1-1 displays accelerated development and early flowering mediated by the hormone gibberellic acid
Arabidopsis defense mutant ndr1-1 displays accelerated development and early flowering mediated by the hormone gibberellic acid Open
NONRACE-SPECIFIC DISEASE RESISTANCE (NDR1) is a widely characterized gene that plays a key role in defense against multiple bacterial, fungal, oomycete and nematode plant pathogens. NDR1 is required for activation of resistance by multiple…
View article: Exceptional subgenome stability and functional divergence in allotetraploid teff, the primary cereal crop in Ethiopia
Exceptional subgenome stability and functional divergence in allotetraploid teff, the primary cereal crop in Ethiopia Open
Teff ( Eragrostis tef ) is a cornerstone of food security in the Horn of Africa, where it is prized for stress resilience, grain nutrition, and market value. Despite its overall importance to small-scale farmers and communities in Africa, …
View article: Author Correction: Origin and evolution of the octoploid strawberry genome
Author Correction: Origin and evolution of the octoploid strawberry genome Open