Jennifer E. Wu
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View article: Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8<sup>+</sup> T cells underlies distinct functional potential
Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8<sup>+</sup> T cells underlies distinct functional potential Open
Persistent antigen stimulation promotes differentiation of exhausted CD8 + T (T EX ) cells. T EX cells are distinct from circulating memory T (T CIRCM ) cells but share many features with tissue-resident memory (T RM ) cells established fo…
View article: 1016 Enforcement of exhausted T cell epigenetic fate by HMG-box transcription factor TOX
1016 Enforcement of exhausted T cell epigenetic fate by HMG-box transcription factor TOX Open
Background T cell exhaustion is one of the major barriers limiting efficacious anti-tumor therapy. Exhausted CD8 T cells (TEX) develop following persistent antigen stimulation and are characterized by a unique epigenetic state, expression …
View article: <i>In Vitro</i>Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40
<i>In Vitro</i>Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40 Open
Identifying novel molecular mechanisms of exhausted CD8 T cells (T ex ) is a key goal of improving immunotherapy of cancer and other diseases. However, high-throughput interrogation of in vivo T ex can be costly and inefficient. In vitro m…
View article: Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates
Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates Open
Naïve CD8 T cells can differentiate into effector (T EFF ), memory (T MEM ), or exhausted (T EX ) CD8 T cells. These developmental pathways are associated with distinct transcriptional and epigenetic changes that endow cells with different…
View article: Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19
Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19 Open
Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with h…
View article: Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19
Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19 Open
Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with h…
View article: Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19 Open
MIS-C is defined by lymphocyte activation, including elevated plasmablast frequencies and marked activation of CX3CR1 + CD8 + T cells.
View article: CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer
CD8 T cells compensate for impaired humoral immunity in COVID-19 patients with hematologic cancer Open
Cancer patients have increased morbidity and mortality from Coronavirus Disease 2019 (COVID-19), but the underlying immune mechanisms are unknown. In a cohort of 100 cancer patients hospitalized for COVID-19 at the University of Pennsylvan…
View article: Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications Open
Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a compr…
View article: Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions Open
COVID-19 has become a global pandemic. Immune dysregulation has been implicated, but immune responses remain poorly understood. We analyzed 71 COVID-19 patients compared to recovered and healthy subjects using high dimensional cytometry. I…
View article: <i>In vivo</i>CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer
<i>In vivo</i>CRISPR screening identifies Fli1 as a transcriptional safeguard that restrains effector CD8 T cell differentiation during infection and cancer Open
Summary Improving effector activity of antigen specific T cells is a major goal in cancer immunotherapy. Despite the identification of several effector T cell (T EFF )-driving transcription factors (TF), the transcriptional coordination of…
View article: Chronic viral infection promotes early germinal center exit of B cells and impaired antibody development
Chronic viral infection promotes early germinal center exit of B cells and impaired antibody development Open
SUMMARY Chronic viral infections disrupt B cell responses leading to impaired affinity maturation and delayed control of viremia. Previous studies have identified early pre-germinal center (GC) B cell attrition but the impact of chronic in…
View article: Pathological Role of Anti-CD4 Antibodies in HIV-Infected Immunologic Nonresponders Receiving Virus-Suppressive Antiretroviral Therapy
Pathological Role of Anti-CD4 Antibodies in HIV-Infected Immunologic Nonresponders Receiving Virus-Suppressive Antiretroviral Therapy Open
Increased mortality and morbidity occur among human immunodeficiency virus (HIV)-infected patients in whom CD4+ T-cell counts do not increase despite viral suppression with antiretroviral therapy (ART). Here we identified an underlying mec…
View article: Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique
Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique Open
A range of current candidate AIDS vaccine regimens are focused on generating protective HIV-neutralizing Ab responses. Many of these efforts rely on the rhesus macaque animal model. Understanding how protective Ab responses develop and how…
View article: CXCL13 is a plasma biomarker of germinal center activity
CXCL13 is a plasma biomarker of germinal center activity Open
Significance A major challenge for vaccine science is that there is no way to measure germinal center activity in humans. This challenge is particularly acute for human clinical trials of candidate vaccines (and most nonhuman primate studi…