Jennifer F. Morton
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View article: Perspectives on App-Assisted Self-Testing Using Rapid Diagnostic Tests Among Community Members, Health Care Providers, and Public Health Leaders in Kenya, South Africa, and Zambia: Qualitative Study
Perspectives on App-Assisted Self-Testing Using Rapid Diagnostic Tests Among Community Members, Health Care Providers, and Public Health Leaders in Kenya, South Africa, and Zambia: Qualitative Study Open
Background Self-testing using rapid diagnostic tests (RDTs), integrated with mobile phone–based apps, offers potential to improve health outcomes in low-resource settings, including sub-Saharan Africa. Despite its advantages, uptake remain…
View article: Household healthcare seeking patterns for emergent ill-health in Migori, Western Kenya
Household healthcare seeking patterns for emergent ill-health in Migori, Western Kenya Open
Background Healthcare-seeking decisions reflect personal assessments of illness etiology and severity to determine whether, how, and where to seek care. Understanding these contexts enables targeted interventions to address barriers and en…
View article: Feasibility and Preferences for Home-based Self-Testing for HIV, Diabetes, and Hypertension in Kenya, South Africa, and Zambia
Feasibility and Preferences for Home-based Self-Testing for HIV, Diabetes, and Hypertension in Kenya, South Africa, and Zambia Open
Home-based self-testing may improve individual health outcomes and public health disease surveillance by lowering the barriers associated with clinic-based diagnostic testing in low- and middle-income countries (LMICs). We assessed the fea…
View article: Disease priorities and rapid diagnostics testing preferences among community members in KwaZulu-Natal, South Africa: a formative qualitative study
Disease priorities and rapid diagnostics testing preferences among community members in KwaZulu-Natal, South Africa: a formative qualitative study Open
Objective To explore and understand the disease priorities and preferences for rapid diagnostic testings (RDTs) among community members and stakeholders. Design Qualitative study using focused group discussions and in-depth interviews. The…
View article: Integrating oral pre-exposure prophylaxis delivery in primary care family planning clinics: a pragmatic, stepped-wedge, cluster-randomised trial
Integrating oral pre-exposure prophylaxis delivery in primary care family planning clinics: a pragmatic, stepped-wedge, cluster-randomised trial Open
View article: Impact of Previous Infection or Vaccination on Clinical Symptoms and Viral Load of Acute SARS-CoV-2 Infection
Impact of Previous Infection or Vaccination on Clinical Symptoms and Viral Load of Acute SARS-CoV-2 Infection Open
View article: Evaluating the effectiveness of a One-Stop PrEP Care model to enhance HIV prevention: a protocol for a cluster-randomised trial in Kisumu County, Kenya
Evaluating the effectiveness of a One-Stop PrEP Care model to enhance HIV prevention: a protocol for a cluster-randomised trial in Kisumu County, Kenya Open
Introduction Oral HIV pre-exposure prophylaxis (PrEP) is a highly effective biomedical intervention for HIV prevention, but its access and utilisation are challenging, especially in high-burden settings such as Kenya. For potential PrEP us…
View article: ThiPhiSA: new pathways to TB prevention from community screening – a household-randomised controlled trial in KwaZulu-Natal, South Africa
ThiPhiSA: new pathways to TB prevention from community screening – a household-randomised controlled trial in KwaZulu-Natal, South Africa Open
Introduction Tuberculosis (TB) remains the leading cause of infectious disease deaths, particularly among people living with HIV (PWH). Despite being preventable, TB preventive therapy (TPT) uptake is low in high-burden regions like South …
View article: Diagnostic accuracy of tongue swab testing in persons with sputum Xpert Ultra Trace results
Diagnostic accuracy of tongue swab testing in persons with sputum Xpert Ultra Trace results Open
Background Molecular amplification of tongue swab samples is a non-sputum-based investigational approach to diagnose pulmonary tuberculosis (pTB). An improved manual qPCR method for tongue swabs recently achieved >90% sensitivity overall i…
View article: Cumulative TB disease burden following sputum Xpert Ultra ‘Trace’ results in clinical settings: Results from a multi-site observational clinical study
Cumulative TB disease burden following sputum Xpert Ultra ‘Trace’ results in clinical settings: Results from a multi-site observational clinical study Open
Background Highly sensitive molecular tests, like Xpert Ultra, are reshaping TB diagnosis—detecting paucibacillary TB but sometimes creating uncertainty when they detect DNA in extremely low quantities that may not signal disease. This amb…
View article: “When he is around, I’ll take the PrEP, but when he is not, I will not take PrEP”: key influences on PrEP use decisions among women attending family planning clinics in Kenya
“When he is around, I’ll take the PrEP, but when he is not, I will not take PrEP”: key influences on PrEP use decisions among women attending family planning clinics in Kenya Open
Background Women of childbearing age in sub-Saharan Africa (SSA) face a disproportionately high risk of HIV acquisition. Although oral PrEP has been universally scaled up for individuals at significant risk of HIV, its uptake and sustained…
View article: Trajectories of PrEP Adherence Among Young Women Aged 16 to 25 in Cape Town, South Africa
Trajectories of PrEP Adherence Among Young Women Aged 16 to 25 in Cape Town, South Africa Open
View article: Integrating Pre-Exposure Prophylaxis Delivery in Primary Care Family Planning Clinics: A Pragmatic Stepped-Wedge Cluster Randomized Trial
Integrating Pre-Exposure Prophylaxis Delivery in Primary Care Family Planning Clinics: A Pragmatic Stepped-Wedge Cluster Randomized Trial Open
View article: Perspectives on App-Assisted Self-Testing Using Rapid Diagnostic Tests Among Community Members, Health Care Providers, and Public Health Leaders in Kenya, South Africa, and Zambia: Qualitative Study (Preprint)
Perspectives on App-Assisted Self-Testing Using Rapid Diagnostic Tests Among Community Members, Health Care Providers, and Public Health Leaders in Kenya, South Africa, and Zambia: Qualitative Study (Preprint) Open
BACKGROUND Self-testing using rapid diagnostic tests (RDTs), integrated with mobile phone–based apps, offers potential to improve health outcomes in low-resource settings, including sub-Saharan Africa. Despite its advantages, uptake remai…
View article: Real-world diagnostic accuracy of lipoarabinomannan in three non-sputum biospecimens for pulmonary tuberculosis disease
Real-world diagnostic accuracy of lipoarabinomannan in three non-sputum biospecimens for pulmonary tuberculosis disease Open
View article: Exploring adolescent girls and young women's PrEP‐user profiles: qualitative insights into differentiated PrEP delivery platform selection and engagement in Cape Town, South Africa
Exploring adolescent girls and young women's PrEP‐user profiles: qualitative insights into differentiated PrEP delivery platform selection and engagement in Cape Town, South Africa Open
Introduction Adolescent girls and young women (AGYW), a priority population for HIV prevention in Africa, show high interest but difficulty in sustained effective use of pre‐exposure prophylaxis (PrEP). With ongoing PrEP scale‐up focused o…
View article: Family influences on oral PrEP use among adolescent girls and young women in Kenya and South Africa
Family influences on oral PrEP use among adolescent girls and young women in Kenya and South Africa Open
Introduction Effective use of oral HIV pre-exposure prophylaxis (PrEP) has been lower among African adolescent girls and young women (AGYW) than among older women, young men who have sex with men, and serodiscordant heterosexual couples in…
View article: A decision support tool has similar high PrEP uptake and increases early PrEP persistence in adolescent girls and young women in South Africa: results from a randomized controlled trial
A decision support tool has similar high PrEP uptake and increases early PrEP persistence in adolescent girls and young women in South Africa: results from a randomized controlled trial Open
Introduction African adolescent girls and young women (AGYW) have high rates of HIV acquisition and are a priority population for HIV pre‐exposure prophylaxis (PrEP). PrEP implementation has been limited by AGYW's low perceived HIV risk an…
View article: Patterns of PrEP continuation and coverage in the first year of use: a latent class analysis of a programmatic PrEP trial in Kenya
Patterns of PrEP continuation and coverage in the first year of use: a latent class analysis of a programmatic PrEP trial in Kenya Open
Introduction Effective PrEP use is critical for impact, but data are limited on common patterns of continuation and coverage among persons using PrEP in real‐world settings. Methods Data are from the Partners Scale‐Up Project, a programmat…
View article: Association of sexual relationship power with PrEP persistence and other sexual health outcomes among adolescent and young women in Kenya and South Africa
Association of sexual relationship power with PrEP persistence and other sexual health outcomes among adolescent and young women in Kenya and South Africa Open
Introduction Gendered power inequalities impact adolescent girls’ and young women's (AGYW) sexual and reproductive health (SRH) outcomes. We investigated the influence of sexual relationship power on AGYW's SRH outcomes, including HIV pre-…
View article: COVID-19 Antigen Results Correlate with the Quantity of Replication-Competent SARS-CoV-2 in a Cross-Sectional Study of Ambulatory Adults during the Delta Wave
COVID-19 Antigen Results Correlate with the Quantity of Replication-Competent SARS-CoV-2 in a Cross-Sectional Study of Ambulatory Adults during the Delta Wave Open
Do rapid antigen test results correlate with replication-competent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (i.e., infectious) virus? In this cross-sectional diagnostic study of 626 adults, the sensitivity of the antige…
View article: Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron
Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron Open
New variants of SARS-CoV-2 continue to emerge and evade immunity. We isolated SARS-CoV-2 temporally across the pandemic starting with the first emergence of the virus in the western hemisphere and evaluated the immune escape among variants…
View article: Duration of viral infectiousness and correlation with symptoms and diagnostic testing in non-hospitalized adults during acute SARS-CoV-2 infection: A longitudinal cohort study
Duration of viral infectiousness and correlation with symptoms and diagnostic testing in non-hospitalized adults during acute SARS-CoV-2 infection: A longitudinal cohort study Open
View article: Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron
Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron Open
New variants of SARS-CoV-2 continue to emerge and evade immunity. We isolated SARS-CoV-2 temporally across the pandemic starting with the first emergence of the virus in the western hemisphere and evaluated the immune escape among variants…
View article: Provider perspectives on service delivery modifications to maintain access to HIV pre‐exposure prophylaxis during the COVID‐19 pandemic: qualitative results from a PrEP implementation project in Kenya
Provider perspectives on service delivery modifications to maintain access to HIV pre‐exposure prophylaxis during the COVID‐19 pandemic: qualitative results from a PrEP implementation project in Kenya Open
Introduction HIV pre‐exposure prophylaxis (PrEP) is an essential prevention strategy being scaled up for priority populations in Kenya, including for HIV serodiscordant couples. The COVID‐19 pandemic posed challenges to PrEP rollout. We co…
View article: 307. Diagnostic Test Kinetics, Infectivity, and Immunological Responses Among Unvaccinated Adults During Acute SARS-CoV-2 Infection
307. Diagnostic Test Kinetics, Infectivity, and Immunological Responses Among Unvaccinated Adults During Acute SARS-CoV-2 Infection Open
Background Appropriate diagnostic testing can be used to inform infection control measures and reduce SARS-CoV-2 transmission, yet the test kinetics, infectivity, and immunological responses during acute, non-severe SARS-CoV-2 infection ne…
View article: Provider–client rapport in pre-exposure prophylaxis delivery: a qualitative analysis of provider and client experiences of an implementation science project in Kenya
Provider–client rapport in pre-exposure prophylaxis delivery: a qualitative analysis of provider and client experiences of an implementation science project in Kenya Open
Daily oral pre-exposure prophylaxis (PrEP) is being incorporated into services frequented by adolescent girls and young women (AGYW) in sub-Saharan Africa who are at a significant risk of HIV. In non-PrEP studies, positive provider-client …
View article: Duration of viral infectiousness and correlation with symptoms and diagnostic testing in non-hospitalized adults during acute SARS-CoV-2 infection: A longitudinal cohort study
Duration of viral infectiousness and correlation with symptoms and diagnostic testing in non-hospitalized adults during acute SARS-CoV-2 infection: A longitudinal cohort study Open
Background Guidelines for SARS-CoV-2 have relied on limited data on duration of viral infectiousness and correlation with COVID-19 symptoms and diagnostic testing. Methods We enrolled ambulatory adults with acute SARS-CoV-2 infection and p…
View article: Accuracy of 2 Rapid Antigen Tests During 3 Phases of SARS-CoV-2 Variants
Accuracy of 2 Rapid Antigen Tests During 3 Phases of SARS-CoV-2 Variants Open
Importance Variants of SARS-CoV-2 have sequence variations in the viral genome that may alter the accuracy of rapid diagnostic tests. Objective To assess the analytical and clinical accuracy of 2 rapid diagnostic tests for detecting SARS-C…
View article: Dynamics of SARS-CoV-2 VOC neutralization and novel mAb reveal protection against Omicron
Dynamics of SARS-CoV-2 VOC neutralization and novel mAb reveal protection against Omicron Open
To evaluate SARS-CoV-2 variants we isolated SARS-CoV-2 temporally during the pandemic starting with first appearance of virus in the Western hemisphere near Seattle, WA, USA, and isolated each known major variant class, revealing the dynam…