Jennifer Frein
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View article: Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction
Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction Open
LRRK2 polymorphisms (G2019S/N2081D) that increase susceptibility to Parkinson’s disease and Crohn’s disease (CD) lead to LRRK2 kinase hyperactivity and suppress autophagy. This connection suggests that LRRK2 kinase inhibition, a therapeuti…
View article: Western diet reduces small intestinal intraepithelial lymphocytes via FXR-Interferon pathway
Western diet reduces small intestinal intraepithelial lymphocytes via FXR-Interferon pathway Open
The prevalence of obesity in the United States has continued to increase over the past several decades. Understanding how diet-induced obesity modulates mucosal immunity is of clinical relevance. We previously showed that consumption of a …
View article: WESTERN DIET DEPLETES SMALL INTESTINAL INTRAEPITHELIAL LYMPHOCYTES VIA FXR-INTERFERON PATHWAY
WESTERN DIET DEPLETES SMALL INTESTINAL INTRAEPITHELIAL LYMPHOCYTES VIA FXR-INTERFERON PATHWAY Open
BACKGROUND The prevalence of obesity has continued to increase over the past several decades. Understanding how diet-induced obesity modulates mucosal immunity is of clinical relevance. We previously showed that consumption of a high fat, …
View article: NAD <sup>+</sup> precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction
NAD <sup>+</sup> precursors and bile acid sequestration treat preclinical refractory environmental enteric dysfunction Open
Environmental enteric dysfunction (EED) is a diffuse small bowel disorder associated with poor growth, inadequate responses to oral vaccines, and nutrient malabsorption in millions of children worldwide. We identify loss of the small intes…