Jennifer Gale
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View article: Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators
Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators Open
T-type voltage-gated Ca2+ channels have been implicated in many human disorders, and there has been increasing interest in developing highly selective and potent T-type Ca2+ channel modulators for potential clinical use. However, the uniqu…
View article: Virtual screening for small molecule pathway regulators by image profile matching
Virtual screening for small molecule pathway regulators by image profile matching Open
Identifying chemical regulators of biological pathways is a time-consuming bottleneck in developing therapeutics and research compounds. Typically, thousands to millions of candidate small molecules are tested in target-based biochemical s…
View article: Dysfunction of D2 dopamine receptor expressing neurons underlies manic-like behaviors in mice modeling SHANK3 duplication disorder
Dysfunction of D2 dopamine receptor expressing neurons underlies manic-like behaviors in mice modeling SHANK3 duplication disorder Open
While the contributions of some genes to neuropsychiatric disorders are clear, the downstream neuronal effects are poorly understood. Over-expression of SHANK3, which encodes a key synaptic protein, causes neuropsychiatric phenotypes in hu…
View article: Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection
Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection Open
Selective histone deacetylase (HDAC) inhibitors have emerged as a potential anti-latency therapy for persistent human immunodeficiency virus type 1 (HIV-1) infection. We utilized a combination of small molecule inhibitors and short hairpin…
View article: Conservation of the structure and function of bacterial tryptophan synthases
Conservation of the structure and function of bacterial tryptophan synthases Open
Tryptophan biosynthesis is one of the most characterized processes in bacteria, in which the enzymes from Salmonella typhimurium and Escherichia coli serve as model systems. Tryptophan synthase (TrpAB) catalyzes the final two steps of tryp…
View article: Flower‐visitor communities of an arcto‐alpine plant—Global patterns in species richness, phylogenetic diversity and ecological functioning
Flower‐visitor communities of an arcto‐alpine plant—Global patterns in species richness, phylogenetic diversity and ecological functioning Open
Pollination is an ecosystem function of global importance. Yet, who visits the flower of specific plants, how the composition of these visitors varies in space and time and how such variation translates into pollination services are hard t…
View article: High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of <i>Toxoplasma gondii</i> Growth
High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of <i>Toxoplasma gondii</i> Growth Open
Toxoplasma gondii is an obligate intracellular parasite capable of causing severe disease due to congenital infection and in patients with compromised immune systems. Control of infection is dependent on a robust Th1 type immune response i…
View article: High throughput screen identifies IFN-γ-dependent inhibitors of <i>Toxoplasma gondii</i> growth
High throughput screen identifies IFN-γ-dependent inhibitors of <i>Toxoplasma gondii</i> growth Open
Toxoplasma gondii is an obligate intracellular parasite capable of causing severe disease due to congenital infection and in patients with compromised immune systems. Control of infection is dependent on a robust Th1 type immune response i…
View article: Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia
Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia Open
Paralog-selective inhibitors of GSK3 kinases were designed by exploiting a single amino acid difference in their ATP-binding domains and studied in AML.
View article: Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects
Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects Open
The mood stabilizer lithium, the first-line treatment for bipolar disorder, is hypothesized to exert its effects through direct inhibition of glycogen synthase kinase 3 (GSK3) and indirectly by increasing GSK3's inhibitory serine phosphory…
View article: An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection Open
Modulation of histone deacetylase (HDAC) activity has been implicated as a potential therapeutic strategy for multiple diseases. However, it has been difficult to dissect the role of individual HDACs due to a lack of selective small-molecu…
View article: Chromatin immunoprecipitation (ChIP) of nucleus accumbens from Cpd-60 treated mice.
Chromatin immunoprecipitation (ChIP) of nucleus accumbens from Cpd-60 treated mice. Open
(a) Schematic of experimental design with 10-day administration of Cpd-60 (45 mg/kg, i.p.). (b) Chromatin was immunoprecipitated with an anti-histone H4K12ac-antibody followed by qPCR targeting regions 1.0 or 0.2 kB upstream or 0.5 kB down…