Jennifer Hampton Hill
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View article: A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy
A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy Open
View article: Intestinal fungal-host interactions in promoting and maintaining health
Intestinal fungal-host interactions in promoting and maintaining health Open
View article: Clec12a tempers inflammation while restricting expansion of a colitogenic commensal
Clec12a tempers inflammation while restricting expansion of a colitogenic commensal Open
SUMMARY Regulation of the microbiota is critical to intestinal health yet the mechanisms employed by innate immunity remain unclear. Here we show that mice deficient in the C-Type-lectin receptor, Clec12a developed severe colitis, which wa…
View article: BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass
BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass Open
View article: CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis
CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis Open
Intercellular communication is critical for homeostasis in mammalian systems, including the gastrointestinal (GI) tract. Exosomes are nanoscale lipid extracellular vesicles that mediate communication between many cell types. Notably, the r…
View article: A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass
A microbiota membrane disrupter disseminates to the pancreas and increases β-cell mass Open
Summary Microbiome dysbiosis is a feature of diabetes, but how microbial products influence insulin production is poorly understood. Here we report the mechanism of BefA, a microbiome-derived protein that increases proliferation of insulin…
View article: SnapShot: Microbiota effects on host physiology
SnapShot: Microbiota effects on host physiology Open
View article: Impact of an Inpatient Diabetes Consulting Service on Post Discharge Glycemic Control
Impact of an Inpatient Diabetes Consulting Service on Post Discharge Glycemic Control Open
"Diabetes mellitus has been estimated to affect 30 million Americans in 2015 with an increasing prevalence every year 1. In addition, patients with diabetes have up to a 3-fold increased risk of hospitalization 2. The health care cost for …
View article: Bacterial Regulation of Host Pancreatic Beta Cell Development
Bacterial Regulation of Host Pancreatic Beta Cell Development Open
Diabetes is a metabolic disease characterized by the loss of functional pancreatic beta cells. The incidence of diabetes has risen rapidly in recent decades, which has been attributed at least partially to alterations in host-associated mi…
View article: A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development
A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development Open
Resident microbes play important roles in the development of the gastrointestinal tract, but their influence on other digestive organs is less well explored. Using the gnotobiotic zebrafish, we discovered that the normal expansion of the p…
View article: Author response: A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development
Author response: A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Material and methods References Decision letter Author response Article and author information Metrics Abstract Resident microbes play important roles in the de…