Jennifer Horowitz
YOU?
Author Swipe
View article: Developing an approach to enhance recruitment for a cluster-randomised implementation trial: leveraging deliberative participation and credible messengers
Developing an approach to enhance recruitment for a cluster-randomised implementation trial: leveraging deliberative participation and credible messengers Open
Objectives To evaluate an innovative approach to recruit 40 hospitals to a cluster randomised controlled trial (RCT) to improve discharge antibiotic prescribing. Design This study describes the design, implementation and impact of a theory…
View article: Safety of Vancomycin Use Through Midline Catheters for Outpatient Parenteral Antimicrobial Therapy
Safety of Vancomycin Use Through Midline Catheters for Outpatient Parenteral Antimicrobial Therapy Open
This cohort study examines the association between vancomycin use through midline catheters and device-related complications among patients receiving outpatient parenteral antimicrobial therapy.
View article: Influence of Access to Care on Decision-making About Antibiotic Duration at Discharge
Influence of Access to Care on Decision-making About Antibiotic Duration at Discharge Open
In a randomized vignette of an inpatient with pneumonia, hospitalists prescribed a longer antibiotic duration (>5 days) on discharge more often if the patient lived in a (A) rural versus (B) local community (37% [11/29] vs 10% [4/42], P…
View article: Epidemiologic Characteristics and Management of Sepsis Among Previously Healthy Patients
Epidemiologic Characteristics and Management of Sepsis Among Previously Healthy Patients Open
Background: Most deaths resulting from sepsis occur among patients with advanced age, multiple morbidities, or frailty. It is unclear how many sepsis-related deaths truly are preventable. Previously healthy patients may provide insight int…
View article: P-1661. Characteristics and Outcomes Associated with Treatment of Asymptomatic Bacteriuria Among Patients with Neurogenic Bladder in a Statewide Hospital Database
P-1661. Characteristics and Outcomes Associated with Treatment of Asymptomatic Bacteriuria Among Patients with Neurogenic Bladder in a Statewide Hospital Database Open
Background Inappropriate treatment of asymptomatic bacteriuria (ASB) among hospitalized patients leads to longer length of stay (LOS) without improving outcomes. ASB is common in individuals with neurogenic bladder (NB); however, little is…
View article: 305. Hospitalized Patients with Community-Acquired Pneumonia and Structural Lung Disease: A Multicenter Analysis
305. Hospitalized Patients with Community-Acquired Pneumonia and Structural Lung Disease: A Multicenter Analysis Open
Background Patients with structural lung disease (SLD) are more susceptible to community-acquired pneumonia (CAP) and are at higher risk for resistant organisms. CAP studies often exclude patients with SLD making it difficult to determine …
View article: Midline vs Peripherally Inserted Central Catheter for Outpatient Parenteral Antimicrobial Therapy
Midline vs Peripherally Inserted Central Catheter for Outpatient Parenteral Antimicrobial Therapy Open
Importance Little is known about the safety of midline catheters vs peripherally inserted central catheters (PICCs) for outpatient parenteral antimicrobial therapy (OPAT). Objective To compare outcomes from midline catheters vs PICCs for O…
View article: Development and Validation of the Hospital Medicine Safety Sepsis Initiative Mortality Model
Development and Validation of the Hospital Medicine Safety Sepsis Initiative Mortality Model Open
View article: Inappropriate Diagnosis of Pneumonia Among Hospitalized Adults
Inappropriate Diagnosis of Pneumonia Among Hospitalized Adults Open
Importance Little is known about incidence of, risk factors for, and harms associated with inappropriate diagnosis of community-acquired pneumonia (CAP). Objective To characterize inappropriate diagnosis of CAP in hospitalized patients. De…
View article: Bacteremia From a Presumed Urinary Source in Hospitalized Adults With Asymptomatic Bacteriuria
Bacteremia From a Presumed Urinary Source in Hospitalized Adults With Asymptomatic Bacteriuria Open
Importance Guidelines recommend withholding antibiotics in asymptomatic bacteriuria (ASB), including among patients with altered mental status (AMS) and no systemic signs of infection. However, ASB treatment remains common. Objectives To d…
View article: Protocol for a parallel cluster randomized trial of a participatory tailored approach to reduce overuse of antibiotics at hospital discharge: the ROAD home trial
Protocol for a parallel cluster randomized trial of a participatory tailored approach to reduce overuse of antibiotics at hospital discharge: the ROAD home trial Open
Background Antibiotic overuse at hospital discharge is common, costly, and harmful. While discharge-specific antibiotic stewardship interventions are effective, they are resource-intensive and often infeasible for hospitals with resource c…
View article: Development of Patient Safety Measures to Identify Inappropriate Diagnosis of Common Infections
Development of Patient Safety Measures to Identify Inappropriate Diagnosis of Common Infections Open
Background Inappropriate diagnosis of infections results in antibiotic overuse and may delay diagnosis of underlying conditions. Here we describe the development and characteristics of 2 safety measures of inappropriate diagnosis of urinar…
View article: The role of hospital‐based vascular access teams and implications for patient safety: A multi‐methods study
The role of hospital‐based vascular access teams and implications for patient safety: A multi‐methods study Open
Background Peripherally inserted central catheters (PICCs) and midline catheters are often placed by nurse‐led vascular access teams (VATs). While some data regarding the effectiveness of these teams exists, less is known about their struc…
View article: Excellence in Antibiotic Stewardship: A Mixed-Methods Study Comparing High-, Medium-, and Low-Performing Hospitals
Excellence in Antibiotic Stewardship: A Mixed-Methods Study Comparing High-, Medium-, and Low-Performing Hospitals Open
Background Despite antibiotic stewardship programs existing in most acute care hospitals, there continues to be variation in appropriate antibiotic use. While existing research examines individual prescriber behavior, contextual reasons fo…
View article: 2724. Community-acquired Pneumonia in Immunocompromised Patients: Predictors and Outcomes Associated with Empiric Broad-spectrum Antibiotic Treatment
2724. Community-acquired Pneumonia in Immunocompromised Patients: Predictors and Outcomes Associated with Empiric Broad-spectrum Antibiotic Treatment Open
Background Immunocompromised patients (ICP) are at higher risk of infection, but are often excluded from trials for community-acquired pneumonia (CAP). Due to limited data on CAP treatment in ICP, the IDSA/ATS CAP guideline omits recommend…
View article: Institutional Structures and Processes to Support Sepsis Care: A Multihospital Study
Institutional Structures and Processes to Support Sepsis Care: A Multihospital Study Open
OBJECTIVES: To identify opportunities for improving hospital-based sepsis care and to inform an ongoing statewide quality improvement initiative in Michigan. DESIGN: Surveys on hospital sepsis processes, including a self-assessment of prac…
View article: Sepsis Program Activities in Acute Care Hospitals — National Healthcare Safety Network, United States, 2022
Sepsis Program Activities in Acute Care Hospitals — National Healthcare Safety Network, United States, 2022 Open
Sepsis, life-threatening organ dysfunction secondary to infection, contributes to at least 1.7 million adult hospitalizations and at least 350,000 deaths annually in the United States. Sepsis care is complex, requiring the coordination of …
View article: A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria
A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria Open
Importance Hospitalized patients with asymptomatic bacteriuria (ASB) often receive unnecessary antibiotic treatment, which increases antibiotic resistance and adverse events. Objective To determine whether diagnostic stewardship (avoiding …
View article: Three-day antibiotic duration in patients with pneumonia: A sixty-eight–hospital cohort
Three-day antibiotic duration in patients with pneumonia: A sixty-eight–hospital cohort Open
Background: Since 2019, community-acquired pneumonia (CAP) guidelines have recommended hospitalized patients be treated until clinical “stability and for no less than 5 days.” However, randomized trials have reported that, in patients who …
View article: Risk Factors and outcomes associated with inappropriate empiric broad-spectrum antibiotic use in hospitalized patients with community-acquired pneumonia
Risk Factors and outcomes associated with inappropriate empiric broad-spectrum antibiotic use in hospitalized patients with community-acquired pneumonia Open
Background: Inappropriate broad-spectrum antibiotic use targeting methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa can result in increased adverse events, antibiotic resistance, and Clostridioides difficile inf…
View article: Identifying the relationship between hospital rurality and antibiotic overuse
Identifying the relationship between hospital rurality and antibiotic overuse Open
Background: Antibiotic overuse and the resulting patient outcomes span all hospitals. However, although antibiotic stewardship can improve antibiotic use, effective stewardship programs require expertise and an infrastructure that are not …
View article: Prevalence of and risk factors for bacteremic UTIs in hospitalized adults without definitive signs or symptoms of UTI
Prevalence of and risk factors for bacteremic UTIs in hospitalized adults without definitive signs or symptoms of UTI Open
Background: IDSA guidelines recommend withholding treatment in patients with asymptomatic bacteriuria in the absence of systemic signs of infection. However, some patients with bacteriuria may not be able to express symptoms either due to …
View article: The Association of Vasopressor Administration through a Midline Catheter with Catheter-related Complications
The Association of Vasopressor Administration through a Midline Catheter with Catheter-related Complications Open
Rationale: Little is known about the safety of infusing vasopressors through a midline catheter. Objectives: To evaluate safety outcomes after vasopressor administration through a midline. Methods: We conducted a cohor…
View article: 1592. SHEA Featured Oral Abstract: Reducing Unnecessary Antibiotic Treatment for Asymptomatic Bacteriuria: A Statewide Collaborative Quality Initiative
1592. SHEA Featured Oral Abstract: Reducing Unnecessary Antibiotic Treatment for Asymptomatic Bacteriuria: A Statewide Collaborative Quality Initiative Open
Background Up to one-third of hospitalized patients treated for urinary tract infection (UTI) have asymptomatic bacteriuria (ASB). Both diagnostic (avoiding inappropriate urine cultures) and antibiotic stewardship (reducing unnecessary ant…
View article: 1800. Impact of Updated ATS/IDSA CAP Guidelines on Duration of Antibiotics
1800. Impact of Updated ATS/IDSA CAP Guidelines on Duration of Antibiotics Open
Background In 10/2019, revised ATS/IDSA community-acquired pneumonia (CAP) guidelines removed healthcare-associated pneumonia (HCAP), expanding patients eligible for a 5-day antibiotic course. Using data from 46 hospitals in the Michigan H…
View article: Barriers and facilitators for implementing peripherally inserted central catheter (PICC) appropriateness guidelines: A longitudinal survey study from 34 Michigan hospitals
Barriers and facilitators for implementing peripherally inserted central catheter (PICC) appropriateness guidelines: A longitudinal survey study from 34 Michigan hospitals Open
Peripherally inserted central catheters (PICCs) are prevalent devices for medium-to-long-term intravenous therapy but are often associated with morbid and potentially lethal complications. This multi-center study sought to identify barrier…
View article: Eligibility for Posthospitalization Venous Thromboembolism Prophylaxis in Hospitalized Patients With COVID‐19: A Retrospective Cohort Study
Eligibility for Posthospitalization Venous Thromboembolism Prophylaxis in Hospitalized Patients With COVID‐19: A Retrospective Cohort Study Open
Background A recent randomized trial, the MICHELLE trial, demonstrated improved posthospital outcomes with a 35‐day course of prophylactic rivaroxaban for patients hospitalized with COVID‐19 at high risk of venous thromboembolism. We explo…
View article: Patterns of use and outcomes of peripherally inserted central catheters in hospitalized patients with solid tumors: A multicenter study
Patterns of use and outcomes of peripherally inserted central catheters in hospitalized patients with solid tumors: A multicenter study Open
Background The risk of peripherally inserted central catheter (PICC)‐related complications in patients hospitalized with solid tumors remains unclear. Existing studies are limited by single‐center, outpatient designs and include heterogeno…
View article: Pharmacist gender and physician acceptance of antibiotic stewardship recommendations: An analysis of the reducing overuse of antibiotics at discharge home intervention
Pharmacist gender and physician acceptance of antibiotic stewardship recommendations: An analysis of the reducing overuse of antibiotics at discharge home intervention Open
Objective: To assess association of pharmacist gender with acceptance of antibiotic stewardship recommendations. Design: A retrospective evaluation of the Reducing Overuse of Antibiotics at Discharge (ROAD) Home intervention. Setting: The …
View article: The effect of gender bias on acceptance of antibiotic stewardship recommendations by clinical pharmacists
The effect of gender bias on acceptance of antibiotic stewardship recommendations by clinical pharmacists Open
Background: Clinical pharmacists are a critical part of antibiotic stewardship. Stewardship often relies on relationships and persuasion, which may be affected by gender bias. Thus, we aimed to assess the association of sex with the accept…