Jennifer Imm
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View article: Systemic infections alter cortical transcriptionalsignatures in Alzheimer’s disease
Systemic infections alter cortical transcriptionalsignatures in Alzheimer’s disease Open
Alzheimer’s disease (AD) is characterized by neuroinflammation, yet the impact of concurrent systemic infections on the AD brain remains poorly understood. We investigated the molecular mechanisms underlying the central nervous system resp…
View article: Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signatures
Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signatures Open
Growing evidence suggests that clinical, pathological, and genetic heterogeneity in late onset Alzheimer’s disease (LOAD) contributes to variable therapeutic outcomes, potentially explaining many trial failures. Advances in molecular subty…
View article: A Cell Type Enrichment Analysis Tool for Brain DNA Methylation Data (CEAM)
A Cell Type Enrichment Analysis Tool for Brain DNA Methylation Data (CEAM) Open
DNA methylation signatures are highly cell type-specific, yet most epigenome-wide association studies (EWAS) are performed on bulk tissue, potentially obscuring critical cell type-specific patterns. Existing computational tools for detecti…
View article: Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signatures
Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signatures Open
Growing evidence suggests that clinical, pathological, and genetic heterogeneity in late-onset Alzheimer’s disease contributes to variable therapeutic outcomes, potentially explaining many trial failures. Advances in molecular subtyping th…
View article: Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study
Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study Open
Lewy body (LB) diseases are an umbrella term encompassing a range of neurodegenerative conditions all characterized by the hallmark of intra-neuronal α-synuclein associated with the development of motor and cognitive dysfunction. In this s…
View article: Epigenomic assessment of differential pathological and clinical presentation in the Lewy body dementias
Epigenomic assessment of differential pathological and clinical presentation in the Lewy body dementias Open
Background The Lewy body dementias are a class of neurodegenerative disease encompassing Parkinson’s disease dementia (PDD) and Dementia with Lewy bodies (DLB). Despite similar clinical and neuropathological profiles, the principal differe…
View article: Co‐methylation network analysis of Psychosis in Alzheimer’s disease
Co‐methylation network analysis of Psychosis in Alzheimer’s disease Open
Background Psychosis (broadly delusions and hallucinations) has a cumulative disease prevalence of around 40% in Alzheimer’s disease (AD). The epigenomic, genomic, and neuropathological data provide powerful evidence that AD+P has a distin…
View article: A study of DNA methylation in the prefrontal cortex of heterozygous GBA1 mutant mice
A study of DNA methylation in the prefrontal cortex of heterozygous GBA1 mutant mice Open
Background Epigenome‐wide association studies (EWAS) of DNA methylation are being undertaken in Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB) post‐mortem brain to identify novel disease mechanisms. However, there is consider…
View article: Establishing the contribution of genetic risk loci in the Lewy dody diseases
Establishing the contribution of genetic risk loci in the Lewy dody diseases Open
Background Dementia with Lewy bodies (DLB), Parkinson’s disease (PD) and Parkinson’s disease dementia (PDD) are termed Lewy body diseases (LBDs). These neurodegenerative diseases are classified by the accumulation of alpha‐synuclein in neu…
View article: Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer’s disease in the EMIF‐AD Multimodal Biomarker Discovery study
Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer’s disease in the EMIF‐AD Multimodal Biomarker Discovery study Open
Background The aim of this study was to identify DNA methylation signatures that were associated with 15 CSF biomarker measures of Alzheimer’s disease (AD) or neurodegeneration. Method We profiled DNA methylation in 886 blood samples from …
View article: Characterization of DNA Methylomic Signatures in Induced Pluripotent Stem Cells During Neuronal Differentiation
Characterization of DNA Methylomic Signatures in Induced Pluripotent Stem Cells During Neuronal Differentiation Open
In development, differentiation from a pluripotent state results in global epigenetic changes, although the extent to which this occurs in induced pluripotent stem cell-based neuronal models has not been extensively characterized. In the p…
View article: Characterization of DNA methylomic signatures in induced pluripotent stem cells during neuronal differentiation
Characterization of DNA methylomic signatures in induced pluripotent stem cells during neuronal differentiation Open
Background In development, inducing pluripotency and differentiation into different cell types results in global epigenetic changes, although the extent this occurs in induced pluripotent stem cell (iPSC)‐based neuronal models has not been…
View article: Determining the utility of epigenetic modulators to treat Alzheimer’s disease
Determining the utility of epigenetic modulators to treat Alzheimer’s disease Open
Background It has been previously demonstrated that there are robust and reproducible changes in DNA methylation in Alzheimer’s disease (AD). As these epigenetic changes mediate long lasting alterations in the brain they are attractive dru…
View article: Novel Epigenetic Clock for Fetal Brain Development Predicts Fetal Epigenetic Age for iPSCs and iPSC-Derived Neurons.
Novel Epigenetic Clock for Fetal Brain Development Predicts Fetal Epigenetic Age for iPSCs and iPSC-Derived Neurons. Open
Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system. However, it is unknown how well they capture age-associated processes, p…
View article: Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons
Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons Open
Induced pluripotent stem cells (iPSCs) and their differentiated neurons (iPSC-neurons) are a widely used cellular model in the research of the central nervous system. However, it is unknown how well they capture age-associated processes, p…
View article: P3‐201: EPIGENOMIC PROFILING OF 33QN1 IPSCS THROUGHOUT NEURONAL DIFFERENTIATION: IMPLICATIONS FOR STUDIES OF AGE‐RELATED NEURODEGENERATIVE DISORDERS
P3‐201: EPIGENOMIC PROFILING OF 33QN1 IPSCS THROUGHOUT NEURONAL DIFFERENTIATION: IMPLICATIONS FOR STUDIES OF AGE‐RELATED NEURODEGENERATIVE DISORDERS Open
Since the advent of induced pluripotent stem cells (iPSCs) it's been possible to create disease models that more accurately reflect disease. To date, few have used iPSCs to explore epigenetic dysfunction in common diseases, such as Alzheim…
View article: Microglia in Alzheimer's Disease: A Role for Ion Channels
Microglia in Alzheimer's Disease: A Role for Ion Channels Open
Alzheimer's disease is the most common form of dementia, it is estimated to affect over 40 million people worldwide. Classically, the disease has been characterized by the neuropathological hallmarks of aggregated extracellular amyloid-β a…
View article: P3‐124: EPIGENOMIC PROFILING OF 33QN1 IPSCS THROUGHOUT NEURONAL DIFFERENTIATION
P3‐124: EPIGENOMIC PROFILING OF 33QN1 IPSCS THROUGHOUT NEURONAL DIFFERENTIATION Open
Since the advent of induced pluripotent stem cells (iPSCs) it has been possible to create disease models that more accurately reflect disease. To date, few have used iPSCs to explore epigenetic dysfunction in common diseases, such as Alzhe…