Jennifer K. Frediani
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View article: Real-world implementation of a noninvasive, AI-augmented, anemia-screening smartphone app and personalization for hemoglobin level self-monitoring
Real-world implementation of a noninvasive, AI-augmented, anemia-screening smartphone app and personalization for hemoglobin level self-monitoring Open
Anemia, characterized by low blood hemoglobin (Hgb) levels, afflicts >2 billion individuals worldwide. Here, we report real-world data generated by a smartphone app that noninvasively screens for anemia using only “fingernail selfies.” App…
View article: Respiratory Virus Detection and Sequencing from SARS-CoV-2–Negative Rapid Antigen Tests
Respiratory Virus Detection and Sequencing from SARS-CoV-2–Negative Rapid Antigen Tests Open
Genomic epidemiology offers insight into the transmission and evolution of respiratory viruses. We used metagenomic sequencing from negative SARS-CoV-2 rapid antigen tests to identify a wide range of respiratory viruses and generate full g…
View article: Editorial: Recreational team sports: prevention, treatment, and rehabilitation of non-communicable diseases
Editorial: Recreational team sports: prevention, treatment, and rehabilitation of non-communicable diseases Open
View article: Respiratory virus detection and sequencing from negative SARS-CoV-2 rapid antigen tests
Respiratory virus detection and sequencing from negative SARS-CoV-2 rapid antigen tests Open
Genomic epidemiology offers important insight into the transmission and evolution of respiratory viruses. We used metagenomic sequencing from negative SARS-CoV-2 antigen tests to identify a wide range of respiratory viruses and generate fu…
View article: Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant
Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant Open
Limited data highlight the need to understand differences in SARS-CoV-2 omicron (B.1.1.529) variant viral load between the gold standard nasopharyngeal (NP) swab, mid-turbinate (MT)/anterior nasal swabs, oropharyngeal (OP) swabs, and saliv…
View article: Changes in Diabetes Care and Management Practices during the COVID-19 Pandemic
Changes in Diabetes Care and Management Practices during the COVID-19 Pandemic Open
View article: The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs
The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs Open
Background Early in the coronavirus disease 2019 (COVID-19) pandemic, peak viral loads coincided with symptom onset. We hypothesized that in a highly immune population, symptom onset might occur earlier in infection, coinciding with lower …
View article: Sensitivity of rapid antigen tests against SARS-CoV-2 Omicron and Delta variants
Sensitivity of rapid antigen tests against SARS-CoV-2 Omicron and Delta variants Open
Rapid antigen tests (RATs) have become an invaluable tool for combating the COVID-19 pandemic. However, concerns have been raised regarding the ability of existing RATs to effectively detect emerging SARS-CoV-2 variants. We compared the pe…
View article: Mitigating underreported error in food frequency questionnaire data using a supervised machine learning method and error adjustment algorithm
Mitigating underreported error in food frequency questionnaire data using a supervised machine learning method and error adjustment algorithm Open
Background Food frequency questionnaires (FFQs) are one of the most useful tools for studying and understanding diet-disease relationships. However, because FFQs are self-reported data, they are susceptible to response bias, social desirab…
View article: Prevalence of SARS-CoV-2 in hemoglobinopathies is modified by age and race
Prevalence of SARS-CoV-2 in hemoglobinopathies is modified by age and race Open
View article: The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs
The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs Open
Background Early in the COVID-19 pandemic, peak viral loads coincided with symptom onset. We hypothesized that in a highly immune population, symptom onset might occur earlier in infection, coinciding with lower viral loads. Methods We ass…
View article: Sensitivity of Rapid Antigen Tests Against SARS-CoV-2 Omicron and Delta Variants
Sensitivity of Rapid Antigen Tests Against SARS-CoV-2 Omicron and Delta Variants Open
Rapid Antigen Tests (RAT) have become an invaluable tool for combating the COVID-19 pandemic. However, concerns have been raised regarding the ability of existing RATs to effectively detect emerging SARS-CoV-2 variants. We compared the per…
View article: Severe acute respiratory syndrome coronavirus 2 vaccine breakthrough infections: A single metro-based testing network experience
Severe acute respiratory syndrome coronavirus 2 vaccine breakthrough infections: A single metro-based testing network experience Open
Objectives Understanding the incidence and characteristics that influence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine breakthrough infections (VBIs) is imperative for developing public health policies to mitigate t…
View article: Metabolomics profiling in acute liver transplant rejection in a pediatric population
Metabolomics profiling in acute liver transplant rejection in a pediatric population Open
Pediatric liver transplantation rejection affects 20% of children. Currently, liver biopsy, expensive and invasive, is the best method of diagnosis. Discovery and validation of clinical biomarkers from blood or other biospecimens would imp…
View article: SARS-CoV-2 reliably detected in frozen saliva samples stored up to one year
SARS-CoV-2 reliably detected in frozen saliva samples stored up to one year Open
Viability of saliva samples stored for longer than 28 days has not been reported in the literature. The COVID-19 pandemic has spawned new research evaluating various sample types, thus large biobanks have been started. Residual saliva samp…
View article: Clinical evaluation of the Diagnostic Analyzer for Selective Hybridization (DASH): A point-of-care PCR test for rapid detection of SARS-CoV-2 infection
Clinical evaluation of the Diagnostic Analyzer for Selective Hybridization (DASH): A point-of-care PCR test for rapid detection of SARS-CoV-2 infection Open
Background An ideal test for COVID-19 would combine the sensitivity of laboratory-based PCR with the speed and ease of use of point-of-care (POC) or home-based rapid antigen testing. We evaluated clinical performance of the Diagnostic Anal…
View article: Predictive Value of Isolated Symptoms for Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children Tested During Peak Circulation of the Delta Variant
Predictive Value of Isolated Symptoms for Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children Tested During Peak Circulation of the Delta Variant Open
Background Coronavirus disease 2019 (COVID-19) testing policies for symptomatic children attending US schools or daycare vary, and whether isolated symptoms should prompt testing is unclear. We evaluated children presenting for severe acut…
View article: Machine Learning Approaches to Identify Discriminative Signatures of Volatile Organic Compounds (VOCs) from Bacteria and Fungi Using SPME-DART-MS
Machine Learning Approaches to Identify Discriminative Signatures of Volatile Organic Compounds (VOCs) from Bacteria and Fungi Using SPME-DART-MS Open
Point-of-care screening tools are essential to expedite patient care and decrease reliance on slow diagnostic tools (e.g., microbial cultures) to identify pathogens and their associated antibiotic resistance. Analysis of volatile organic c…
View article: Where is Omicron? Comparison of SARS-CoV-2 RT-PCR and Antigen Test Sensitivity at Commonly Sampled Anatomic Sites Over the Course of Disease
Where is Omicron? Comparison of SARS-CoV-2 RT-PCR and Antigen Test Sensitivity at Commonly Sampled Anatomic Sites Over the Course of Disease Open
Background Upper respiratory samples for SARS-CoV-2 detection include the gold standard nasopharyngeal (NP) swab, and mid-turbinate (MT) nasal swabs, oropharyngeal (OP) swabs, and saliva. Following the emergence of the omicron (B.1.1.529) …
View article: Clinical evaluation of the Diagnostic Analyzer for Selective Hybridization (DASH): a point-of-care PCR test for rapid detection of SARS-CoV-2 infection
Clinical evaluation of the Diagnostic Analyzer for Selective Hybridization (DASH): a point-of-care PCR test for rapid detection of SARS-CoV-2 infection Open
Background Rapid and accurate testing for SARS-CoV-2 is an essential tool in the medical and public health response to the COVID-19 pandemic. An ideal test for COVID-19 would combine the sensitivity of laboratory-based PCR combined with th…
View article: Predictive value of isolated symptoms for diagnosis of SARS-CoV-2 infection in children tested during peak circulation of the delta variant
Predictive value of isolated symptoms for diagnosis of SARS-CoV-2 infection in children tested during peak circulation of the delta variant Open
Background COVID-19 testing policies for symptomatic children attending U.S. schools or daycare vary, and whether isolated symptoms should prompt testing is unclear. We evaluated children presenting for SARS-CoV-2 testing to determine if t…
View article: Metabolic Changes After a 24-Week Soccer-Based Adaptation of the Diabetes Prevention Program in Hispanic Males: A One-Arm Pilot Clinical Trial
Metabolic Changes After a 24-Week Soccer-Based Adaptation of the Diabetes Prevention Program in Hispanic Males: A One-Arm Pilot Clinical Trial Open
Aims: One third of the U.S. adult population is estimated to have obesity-associated prediabetes. Hispanics have a 50% higher type 2 diabetes death rate compared to non-Hispanic whites, yet low participation in lifestyle change programs, m…
View article: Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens
Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens Open
Among symptomatic outpatients, subgenomic RNA of severe acute respiratory syndrome coronavirus 2 in nasal midturbinate swab specimens was concordant with antigen detection but remained detectable in 13 (82.1%) of 16 nasopharyngeal swab spe…
View article: Impacts of Coronavirus Disease 2019 on Oncology Nursing Research
Impacts of Coronavirus Disease 2019 on Oncology Nursing Research Open
The coronavirus disease 2019 (COVID-19) pandemic has, and will continue, to impact oncology nursing research. As in other health-related fields, research is a major enterprise in the discipline of oncology nursing.1 Over the course of the …
View article: The need for new test verification and regulatory support for innovative diagnostics
The need for new test verification and regulatory support for innovative diagnostics Open
been sequenced; and far more samples have been sequenced than are represented in GISAID.In countries with a longer CST lag, the new variants may have enough time to establish themselves across a region 13 if quick tracking, tracing and act…
View article: Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2
Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2 Open
View article: Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration Open
While there has been significant progress in the development of rapid COVID-19 diagnostics, as the pandemic unfolds, new challenges have emerged, including whether these technologies can reliably detect the more infectious variants of conc…
View article: The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change
The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change Open
Faced with the COVID-19 pandemic, the US system for developing and testing technologies was challenged in unparalleled ways. This article describes the multi-institutional, transdisciplinary team of the "RADxSM Tech Test Verific…
View article: The RADx Tech Clinical Studies Core: A Model for Academic Based Clinical Studies
The RADx Tech Clinical Studies Core: A Model for Academic Based Clinical Studies Open
The National Institutes of Health (NIH) launched the Rapid Acceleration of Diagnostics (RADxSM) Tech initiative to support the development and commercialization of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…
View article: Physical fitness and activity changes after a 24-week soccer-based adaptation of the U.S diabetes prevention program intervention in Hispanic men
Physical fitness and activity changes after a 24-week soccer-based adaptation of the U.S diabetes prevention program intervention in Hispanic men Open