Jennifer L. Mason
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View article: Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric CNS tumors
Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric CNS tumors Open
The contribution of rare pathogenic/likely pathogenic (P/LP) germline variants to pediatric central nervous system (CNS) tumor development remains understudied. Here, we characterized the prevalence and clinical significance of germline P/…
View article: The Open Pediatric Cancer Project
The Open Pediatric Cancer Project Open
Background In 2019, the Open Pediatric Brain Tumor Atlas (OpenPBTA) was created as a global, collaborative open-science initiative to genomically characterize 1,074 pediatric brain tumors and 22 patient-derived cell lines. Here, we present…
View article: The Open Pediatric Cancer Project
The Open Pediatric Cancer Project Open
Background In 2019, the Open Pediatric Brain Tumor Atlas (OpenPBTA) was created as a global, collaborative open-science initiative to genomically characterize 1,074 pediatric brain tumors and 22 patient-derived cell lines. Here, we present…
View article: METB-14. INTEGRATED GERMLINE AND SOMATIC PROFILING OF PEDIATRIC BRAIN TUMORS REVEALS INCIDENTAL FINDINGS AND NOVEL TUMOR BIOLOGY
METB-14. INTEGRATED GERMLINE AND SOMATIC PROFILING OF PEDIATRIC BRAIN TUMORS REVEALS INCIDENTAL FINDINGS AND NOVEL TUMOR BIOLOGY Open
BACKGROUND The contribution of rare pathogenic germline variation to central nervous system (CNS) tumor formation in pediatric patients without a family history of cancer remains unclear. METHODS We characterized the prevalence of pathogen…
View article: A multi-institutional pediatric dataset of clinical radiology MRIs by the Children's Brain Tumor Network
A multi-institutional pediatric dataset of clinical radiology MRIs by the Children's Brain Tumor Network Open
Pediatric brain and spinal cancers remain the leading cause of cancer-related death in children. Advancements in clinical decision-support in pediatric neuro-oncology utilizing the wealth of radiology imaging data collected through standar…
View article: METB-11. EXPANSION OF THE PEDIATRIC BRAIN TUMOR ATLAS: AN OPEN SCIENCE EFFORT OF CHILDREN’S BRAIN TUMOR NETWORK, KIDS FIRST DATA RESOURCE AND CHILDHOOD CANCER DATA INITIATIVE
METB-11. EXPANSION OF THE PEDIATRIC BRAIN TUMOR ATLAS: AN OPEN SCIENCE EFFORT OF CHILDREN’S BRAIN TUMOR NETWORK, KIDS FIRST DATA RESOURCE AND CHILDHOOD CANCER DATA INITIATIVE Open
Pediatric central nervous system cancers are the leading disease-related cause of death in children and there is urgent need for curative therapeutic strategies for these tumors. To address the urgency, Children’s Brain Tumor Network (CBTN…
View article: BIOL-22. CHILDREN’S BRAIN TUMOR NETWORK PRECLINICAL TUMOR MODELS DEVELOPMENT AND SHARING PLATFORM: COLLABORATIVE MODEL EMPOWERING PEDIATRIC BRAIN TUMOR DISCOVERY AND GLOBAL RESEARCH
BIOL-22. CHILDREN’S BRAIN TUMOR NETWORK PRECLINICAL TUMOR MODELS DEVELOPMENT AND SHARING PLATFORM: COLLABORATIVE MODEL EMPOWERING PEDIATRIC BRAIN TUMOR DISCOVERY AND GLOBAL RESEARCH Open
Pediatric brain tumor preclinical development has suffered from the lack of robust in vitro and in vivo models that span the large number of brain tumor histologies. Opportunities for precision medicine approaches for solid and brain tumor…
View article: OpenPBTA: The Open Pediatric Brain Tumor Atlas
OpenPBTA: The Open Pediatric Brain Tumor Atlas Open
View article: Data underlying OpenPBTA Manuscript Figures and Molecular Alterations
Data underlying OpenPBTA Manuscript Figures and Molecular Alterations Open
This upload contains CSV files that represent data contained in plots shown in the OpenPBTA manuscript. It is intended to facilitate inspection of the underlying data shown in each figure and to explicitly capture which samples are include…
View article: Data underlying OpenPBTA Manuscript Figures and Molecular Alterations
Data underlying OpenPBTA Manuscript Figures and Molecular Alterations Open
This upload contains CSV files that represent data contained in plots shown in the OpenPBTA manuscript. It is intended to facilitate inspection of the underlying data shown in each figure and to explicitly capture which samples are include…
View article: Data underlying OpenPBTA Manuscript Figures and Molecular Alterations
Data underlying OpenPBTA Manuscript Figures and Molecular Alterations Open
This upload contains CSV files that represent data contained in plots shown in the OpenPBTA manuscript. It is intended to facilitate inspection of the underlying data shown in each figure and to explicitly capture which samples are include…
View article: Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis
Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis Open
View article: The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science Open
Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer…
View article: The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science
The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science Open
View article: EOLP-04. A CALL TO ACTION TO INCREASE ACCESS TO POST-MORTEM BRAIN TUMOR DONATIONS: GIFT FROM A CHILD
EOLP-04. A CALL TO ACTION TO INCREASE ACCESS TO POST-MORTEM BRAIN TUMOR DONATIONS: GIFT FROM A CHILD Open
Implementation of access to donate post mortem tissue among pediatric brain tumor patients remains a challenge[DSM1] . Previous attempts to develop a post-mortem network have been jeopardized by barriers such as a lack of education, logist…
View article: The Children’s Brain Tumor Network (CBTN) - Accelerating Research in Pediatric Central Nervous System Tumors through Collaboration and Open Science
The Children’s Brain Tumor Network (CBTN) - Accelerating Research in Pediatric Central Nervous System Tumors through Collaboration and Open Science Open
Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer…
View article: OpenPBTA: An Open Pediatric Brain Tumor Atlas
OpenPBTA: An Open Pediatric Brain Tumor Atlas Open
Summary Pediatric brain and spinal cancer are the leading disease-related cause of death in children, thus we urgently need curative therapeutic strategies for these tumors. To accelerate such discoveries, the Children’s Brain Tumor Networ…
View article: MODL-30. Children’s Brain Tumor Network preclinical tumor models development and sharing platform: collaborative model empowering pediatric brain tumor discovery and global research.
MODL-30. Children’s Brain Tumor Network preclinical tumor models development and sharing platform: collaborative model empowering pediatric brain tumor discovery and global research. Open
Pediatric brain tumor preclinical field suffered for years from the lack of in vitro and in vivo models. With the explosion of novel therapy approaches for solid and brain tumors, including the immunotherapies it is essential to maximize t…
View article: Genomic Findings in Bone Blood Paired DNA Comparison of Nonsyndromic Craniosynostosis
Genomic Findings in Bone Blood Paired DNA Comparison of Nonsyndromic Craniosynostosis Open
OBJECTIVE: The purpose of this study is to elucidate genetic variants contributing to nonsyndromic craniosynostosis by comparing samples from abnormally fused bones, unaffected bones, and parent saliva, to those from patient peripheral who…
View article: <i>In situ</i>microcosms deployed at the coast of British Columbia (Canada) to study dilbit weathering and associated microbial communities under marine conditions
<i>In situ</i>microcosms deployed at the coast of British Columbia (Canada) to study dilbit weathering and associated microbial communities under marine conditions Open
Douglas Channel and the adjacent Hecate Strait (British Columbia, Canada) are part of a proposed route to ship diluted bitumen (dilbit). This study presents how two types of dilbit naturally degrade in this environment by using an in situ …
View article: OMIC-14. OPENPBTA: AN OPEN PEDIATRIC BRAIN TUMOR ATLAS
OMIC-14. OPENPBTA: AN OPEN PEDIATRIC BRAIN TUMOR ATLAS Open
Pediatric brain tumors comprise a heterogeneous molecular and histological landscape that challenges most current precision-medicine approaches. While recent large-scale efforts to molecularly characterize distinct histological entities ha…
View article: Acknowledgements
Acknowledgements Open
The adventure began with a two-day workshop on creative writing in social research, in Sheffield, in November 2018
View article: PATH-21. TELOMERE LENGTH ANALYSIS OF CNS TUMORS IN THE PEDIATRIC BRAIN TUMOR ATLAS
PATH-21. TELOMERE LENGTH ANALYSIS OF CNS TUMORS IN THE PEDIATRIC BRAIN TUMOR ATLAS Open
Subsets of pediatric cancers, including high grade glioma (pHGG), have high rates of uniquely long telomeres, associated with ATRX gene mutations and alternative lengthening of telomeres (ALT). Ultimately, these cancers may benefit from a …
View article: TBIO-03. THE GIFT FROM A CHILD PROGRAM IS EMPOWERING POST-MORTEM TISSUE DONATION ACROSS THE UNITED STATES
TBIO-03. THE GIFT FROM A CHILD PROGRAM IS EMPOWERING POST-MORTEM TISSUE DONATION ACROSS THE UNITED STATES Open
The Gift from a Child (GFAC) program was inspired by the dream of one child to donate his brain for research, recognizing the need to study tumor tissue collected at diagnosis, recurrence, and at the time of death. Founded by the Swifty Fo…
View article: MODL-26. CHILDREN’S BRAIN TUMOR NETWORK: ACCELERATING RESEARCH THROUGH COLLABORATION AND OPEN-SCIENCE
MODL-26. CHILDREN’S BRAIN TUMOR NETWORK: ACCELERATING RESEARCH THROUGH COLLABORATION AND OPEN-SCIENCE Open
The Children’s Brain Tumor Network (formerly known as Children’s Brain Tumor Consortium- CBTTC) is a global organization pioneering a model of open-science medical research to improve treatment and discover cures. Started in 2011, our obje…
View article: Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer Open
View article: In situ microcosms deployed at the coast of British Columbia (Canada) to study dilbit weathering and associated microbial communities under marine conditions. (Metagenomic data support).
In situ microcosms deployed at the coast of British Columbia (Canada) to study dilbit weathering and associated microbial communities under marine conditions. (Metagenomic data support). Open
This file repository contains the co-assembly of all samples from the manuscript entitled "In situ microcosms deployed at the coast of British Columbia (Canada) to study dilbit weathering and associated microbial communities under marine c…
View article: In situ microcosms deployed at the coast of British Columbia (Canada) to study dilbit weathering and associated microbial communities under marine conditions. (Metagenomic data support).
In situ microcosms deployed at the coast of British Columbia (Canada) to study dilbit weathering and associated microbial communities under marine conditions. (Metagenomic data support). Open
This file repository contains the co-assembly of all samples from the manuscript entitled "In situ microcosms deployed at the coast of British Columbia (Canada) to study dilbit weathering and associated microbial communities under marine c…
View article: Measuring the fate of different diluted bitumen products in coastal surface waters
Measuring the fate of different diluted bitumen products in coastal surface waters Open
Diluted bitumens are produced by adding lower viscosity diluent to highly viscous bitumen to enable it to flow through pipelines and thus may behave differently than conventional oils when spilled into coastal seawater. Simulated surface s…
View article: PDTM-16. PEDIATRIC HIGH GRADE GLIOMA RESOURCES FROM THE CHILDREN’S BRAIN TUMOR TISSUE CONSORTIUM (CBTTC) AND PEDIATRIC BRAIN TUMOR ATLAS (PBTA)
PDTM-16. PEDIATRIC HIGH GRADE GLIOMA RESOURCES FROM THE CHILDREN’S BRAIN TUMOR TISSUE CONSORTIUM (CBTTC) AND PEDIATRIC BRAIN TUMOR ATLAS (PBTA) Open
BACKGROUND Pediatric high grade glioma (pHGG) remains a fatal disease. Access to richly annotated biospecimens and patient derived tumor models will accelerate pHGG research and support translation of research discoveries. This work descri…