Jennifer L. Phillips
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View article: Interventional Psychiatry and Emerging Treatments for Posttraumatic Stress Disorder (PTSD): A Systematic Review
Interventional Psychiatry and Emerging Treatments for Posttraumatic Stress Disorder (PTSD): A Systematic Review Open
This review highlights the heterogeneity in efficacy, safety, and tolerability across neuromodulation and pharmacologic treatments for PTSD. Variability in response rates reflects differences in patient populations, protocols, and comorbid…
View article: 643. RESTING-STATE FUNCTIONAL CONNECTIVITY ASSOCIATIONS WITH SUICIDAL IDEATION SEVERITY IN TREATMENT-RESISTANT DEPRESSION
643. RESTING-STATE FUNCTIONAL CONNECTIVITY ASSOCIATIONS WITH SUICIDAL IDEATION SEVERITY IN TREATMENT-RESISTANT DEPRESSION Open
Background Suicidal ideation is an important modifiable risk factor for suicide in major depressive disorder and understanding its neurobiological underpinnings has important clinical implications. We used resting-state functional magnetic…
View article: A PRELIMINARY INVESTIGATION OF RESTING STATE FUNCTIONAL CONNECTIVITY NETWORKS IN PATIENTS WITH TREATMENT-RESISTANT DEPRESSION AND A HISTORY OF SUICIDE ATTEMPT
A PRELIMINARY INVESTIGATION OF RESTING STATE FUNCTIONAL CONNECTIVITY NETWORKS IN PATIENTS WITH TREATMENT-RESISTANT DEPRESSION AND A HISTORY OF SUICIDE ATTEMPT Open
Background Suicidal ideation (SI) and history of previous suicide attempt (SA) remain the most prominent prognostic factors for completed suicides. Understanding suicide is a nuanced multifaceted issue, and a mounting body of literature ha…
View article: APPLICATION OF MACHINE LEARNING TO LARGE SCALE ELECTRONIC HEALTH RECORD DATA PREDICTS RISK TO READMISSION FOR SUICIDE ATTEMPT
APPLICATION OF MACHINE LEARNING TO LARGE SCALE ELECTRONIC HEALTH RECORD DATA PREDICTS RISK TO READMISSION FOR SUICIDE ATTEMPT Open
Background The period following discharge from a psychiatric inpatient admission is a high risk time for suicidal behaviors and death by suicide up to 200 times the global rate. Leveraging electronic health record (EHR) data in concert wit…
View article: Clusterin induced by OPC phagocytosis blocks IL-9 secretion to inhibit myelination in a model of Alzheimer's disease
Clusterin induced by OPC phagocytosis blocks IL-9 secretion to inhibit myelination in a model of Alzheimer's disease Open
View article: Accumulation of Novel Amyloidosis‐associated proteins in the Progression of Alzheimer’s disease
Accumulation of Novel Amyloidosis‐associated proteins in the Progression of Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is one of the leading causes of death among seniors in the United States and costs the nation over $300 billion each year. Neuropathologically, AD is characterized by neuronal loss, Aβ deposits in the fo…
View article: Impact of severe systemic infections on neuroimmune interactions in neurodegenerative diseases
Impact of severe systemic infections on neuroimmune interactions in neurodegenerative diseases Open
Background Severe systemic infections can trigger cognitive decline, but the underlying mechanisms and their impact on the manifestation and progression of Alzheimer’s disease and other neurodegenerative diseases are poorly understood. The…
View article: Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection
Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection Open
Growing evidence has implicated systemic infection as a significant risk factor for the development and advancement of Alzheimer’s disease (AD). With the emergence of SARS-CoV-2 (COVID-19) and the resultant pandemic, many individuals from …
View article: Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection
Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection Open
Growing evidence has implicated systemic infection as a significant risk factor for the development and advancement of Alzheimer’s disease (AD). With the emergence of SARS-CoV-2 (COVID-19) and the resultant pandemic, many individuals from …
View article: Oligomeric amyloid beta prevents myelination in a clusterin-dependent manner
Oligomeric amyloid beta prevents myelination in a clusterin-dependent manner Open
Background: White matter loss is a well-documented phenomenon in Alzheimer's disease (AD) patients that has been recognized for decades. However, the underlying reasons for the failure of oligodendrocyte progenitor cells (OPCs) to repair m…
View article: Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies Open
The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative diseases (ND), including Alzheimer’s disease (AD) and related dementias (RD), but the recent identification of a mult…
View article: Physician Leadership and Burnout: The Need for Agency; a Qualitative Study of an Academic Institution
Physician Leadership and Burnout: The Need for Agency; a Qualitative Study of an Academic Institution Open
This small study of faculty physician perceptions of leadership behaviors identified several themes that had been identified in previous studies of leadership and burnout; need for relationship building through communication, need for reso…
View article: Transformation of non-neuritic into neuritic plaques during AD progression drives cortical spread of tau pathology via regenerative failure
Transformation of non-neuritic into neuritic plaques during AD progression drives cortical spread of tau pathology via regenerative failure Open
View article: Sustaining the benefits of intravenous ketamine with behavioural activation therapy for depression: A case series
Sustaining the benefits of intravenous ketamine with behavioural activation therapy for depression: A case series Open
Background: Despite advances in treatments for depression, approximately one third of patients do not benefit from available therapies. Intravenous ketamine is a novel intervention that can yield rapid yet transient antidepressant effects.…
View article: Free-Water Diffusion Magnetic Resonance Imaging Differentiates Suicidal Ideation From Suicide Attempt in Treatment-Resistant Depression
Free-Water Diffusion Magnetic Resonance Imaging Differentiates Suicidal Ideation From Suicide Attempt in Treatment-Resistant Depression Open
A unique neural signature consisting of elevated axial diffusivity and free water was identified in patients with TRD and suicide attempt history. Findings of reduced fractional anisotropy, axial diffusivity, and elevated radial diffusivit…
View article: Coadministration of Apalutamide and Relugolix in Patients with Localized Prostate Cancer at High Risk for Metastases
Coadministration of Apalutamide and Relugolix in Patients with Localized Prostate Cancer at High Risk for Metastases Open
View article: International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators
International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators Open
Depression is disabling and highly prevalent. Intravenous (IV) ketamine displays rapid-onset antidepressant properties, but little is known regarding which patients are most likely to benefit, limiting personalized prescriptions. We identi…
View article: A Participant-Level Integrative Data Analysis of Differential Placebo Response for Suicidal Ideation and Nonsuicidal Depressive Symptoms in Clinical Trials of Intravenous Racemic Ketamine
A Participant-Level Integrative Data Analysis of Differential Placebo Response for Suicidal Ideation and Nonsuicidal Depressive Symptoms in Clinical Trials of Intravenous Racemic Ketamine Open
Background Clinical trials of intravenous (IV) racemic (R,S)-ketamine (hereafter referred to as IV ketamine) have consistently reported rapid and substantial reductions in overall depressive symptoms compared with saline (inactive placebo)…
View article: Assessment of Objective and Subjective Cognitive Function in Patients With Treatment-Resistant Depression Undergoing Repeated Ketamine Infusions
Assessment of Objective and Subjective Cognitive Function in Patients With Treatment-Resistant Depression Undergoing Repeated Ketamine Infusions Open
Background Subanesthetic ketamine infusions can elicit rapid and sustained antidepressant effects, yet the potential cognitive impact of ketamine has not been thoroughly examined. This study measured changes in objective and subjective cog…
View article: Free water diffusion MRI differentiates suicide ideators from attempters with treatment-resistant depression
Free water diffusion MRI differentiates suicide ideators from attempters with treatment-resistant depression Open
Suicide attempt is highly prevalent in treatment-resistant depression (TRD), however, the neurobiological profile of suicidal ideation versus suicide attempt is unclear. Neuroimaging methods including diffusion MRI (dMRI) based free water …
View article: The new frontline: exploring the links between moral distress, moral resilience and mental health in healthcare workers during the COVID-19 pandemic
The new frontline: exploring the links between moral distress, moral resilience and mental health in healthcare workers during the COVID-19 pandemic Open
View article: Additional file 2 of The new frontline: exploring the links between moral distress, moral resilience and mental health in healthcare workers during the COVID-19 pandemic
Additional file 2 of The new frontline: exploring the links between moral distress, moral resilience and mental health in healthcare workers during the COVID-19 pandemic Open
Additional file 2.
View article: Electrophysiological correlates and predictors of the antidepressant response to repeated ketamine infusions in treatment-resistant depression
Electrophysiological correlates and predictors of the antidepressant response to repeated ketamine infusions in treatment-resistant depression Open
View article: Emerging New Psychiatric Symptoms and the Worsening of Pre-existing Mental Disorders during the COVID-19 Pandemic: A Canadian Multisite Study: Nouveaux symptômes psychiatriques émergents et détérioration des troubles mentaux préexistants durant la pandémie de la COVID-19: une étude canadienne multisite
Emerging New Psychiatric Symptoms and the Worsening of Pre-existing Mental Disorders during the COVID-19 Pandemic: A Canadian Multisite Study: Nouveaux symptômes psychiatriques émergents et détérioration des troubles mentaux préexistants durant la pandémie de la COVID-19: une étude canadienne multisite Open
Background: The coronavirus disease 2019 (COVID-19) pandemic has caused global disruptions with serious psychological impacts. This study investigated the emergence of new psychiatric symptoms and the worsening of pre-existing mental disor…
View article: The New Frontline: Exploring the Links between Moral Distress, Moral Resilience and Mental Health in Healthcare Workers Amidst the COVID-19 Pandemic
The New Frontline: Exploring the Links between Moral Distress, Moral Resilience and Mental Health in Healthcare Workers Amidst the COVID-19 Pandemic Open
View article: Social, financial and psychological stress during an emerging pandemic: observations from a population survey in the acute phase of COVID-19
Social, financial and psychological stress during an emerging pandemic: observations from a population survey in the acute phase of COVID-19 Open
Introduction The negative impacts of COVID-19 have rippled through every facet of society. Understanding the multidimensional impacts of this pandemic is crucial to identify the most critical needs and to inform targeted interventions. Thi…
View article: Sex-differences in determinants of suicide risk preceding psychiatric admission: An electronic medical record study
Sex-differences in determinants of suicide risk preceding psychiatric admission: An electronic medical record study Open
Using electronic medical record (EMR) data collected from psychiatric inpatient admissions, the objective of this study was to identify sex differences in risk factors for presence of suicide plans and/or attempts within the 30 days preced…
View article: Social, Financial and Psychological Stress during an Emerging Pandemic: Observations from a Population Web-Based Survey in the acute phase of the COVID-19 pandemic
Social, Financial and Psychological Stress during an Emerging Pandemic: Observations from a Population Web-Based Survey in the acute phase of the COVID-19 pandemic Open
Background Understanding the multifaceted impacts of the Coronavirus-19 (COVID-19) outbreak as it unfolds is crucial to identify the most critical needs and to inform targeted interventions. Methods This population survey study presents co…
View article: Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial
Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial Open
(Reprinted with permission from The American Journal of Psychiatry 2019; 176:401-409).
View article: Oligomeric amyloid beta prevents myelination in a clusterin-dependent manner
Oligomeric amyloid beta prevents myelination in a clusterin-dependent manner Open
White matter loss has been described as a common occurrence in Alzheimer’s disease (AD) patients for multiple decades. However, it remains unclear why oligodendrocyte progenitor cells (OPCs) fail to repair myelin deficits in these patients…