Jennifer Logie
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View article: Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence
Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence Open
Colloidal drug aggregates have been a nuisance in drug screening, yet, because they inherently comprise drug-rich particles, they may be useful in vivo if issues of stability can be addressed. As the first step toward answering this questi…
View article: Design and Synthesis of Self-Assembled Polymeric Nanoparticles for Cancer Drug Delivery
Design and Synthesis of Self-Assembled Polymeric Nanoparticles for Cancer Drug Delivery Open
Current chemotherapeutics are plagued by poor solubility and selectivity, requiring toxic excipients in formulations and causing a number of dose limiting side effects. Nanoparticle delivery has emerged as a strategy to more effectively de…
View article: Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations
Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations Open
While limited drug loading continues to be problematic for chemotherapeutics formulated in nanoparticles, we found that we could take advantage of colloidal drug aggregation to achieve high loading when combined with polymeric excipients. …
View article: Internal Structure and Preferential Protein Binding of Colloidal Aggregates
Internal Structure and Preferential Protein Binding of Colloidal Aggregates Open
Colloidal aggregates of small molecules are the most common artifact in early drug discovery, sequestering and inhibiting target proteins without specificity. Understanding their structure and mechanism has been crucial to developing tools…
View article: Docetaxel binding peptide enhances drug loading in polymeric nanomicelles
Docetaxel binding peptide enhances drug loading in polymeric nanomicelles Open
Event Abstract Back to Event Docetaxel binding peptide enhances drug loading in polymeric nanomicelles Jennifer Logie1, 2, Christopher K. Mclaughlin1, 2, Roger Y. Tam1, 2 and Molly S. Shoichet1, 2, 3 1 University of Toronto, Chemical Engin…
View article: Innovative use of the taxol binding peptide overcomes key challenges of stable and high drug loading in polymeric nanomicelles
Innovative use of the taxol binding peptide overcomes key challenges of stable and high drug loading in polymeric nanomicelles Open
Incorporating a taxol binding peptide into the hydrophobic backbone of polymeric nanomicelles enhances docetaxel loading while maintaining serum stability.