Jennifer M. Pilat
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View article: Trsp is required by regulatory T cells to prevent lethal autoimmunity in mice
Trsp is required by regulatory T cells to prevent lethal autoimmunity in mice Open
Selenoproteins are involved in immune cell metabolism, yet the roles of these proteins in T cell development and function remain largely unknown. The Trsp gene encodes the selenocysteine tRNA (tRNASec) required for translation of all selen…
View article: Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice
Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice Open
Interleukin-10 (IL-10) is an immunomodulatory cytokine critical for intestinal immune homeostasis. IL-10 is produced by various immune cells but IL-10 receptor signaling in intestinal CX3CR1+ mononuclear phagocytes is…
View article: Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn’s disease
Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn’s disease Open
View article: MTGR1 is required to maintain small intestinal stem cell populations
MTGR1 is required to maintain small intestinal stem cell populations Open
View article: Animal models of eosinophilic esophagitis
Animal models of eosinophilic esophagitis Open
Eosinophilic esophagitis is a chronic inflammatory disorder of the esophagus. Over the past 25 yr, great strides have been made toward understanding its pathogenesis, in part due to studies in several types of animal models. The vast major…
View article: Distinct roles for interleukin-23 receptor signaling in regulatory T cells in sporadic and inflammation-associated carcinogenesis
Distinct roles for interleukin-23 receptor signaling in regulatory T cells in sporadic and inflammation-associated carcinogenesis Open
Introduction The pro-inflammatory cytokine interleukin-23 (IL-23) has been implicated in colorectal cancer (CRC). Yet, the cell-specific contributions of IL-23 receptor (IL-23R) signaling in CRC remain unknown. One of the cell types that h…
View article: MTGR1 is required to maintain small intestinal stem cell populations
MTGR1 is required to maintain small intestinal stem cell populations Open
Undifferentiated intestinal stem cells (ISCs), particularly those marked by Lgr5, are crucial for maintaining homeostasis and resolving injury. Lgr5+ cells in the crypt base constantly divide, pushing daughter cells upward along the crypt …
View article: Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma
Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma Open
Background/Aims Eosinophils are present in several solid tumors and have context-dependent function. Our aim is to define the contribution of eosinophils in esophageal squamous cell carcinoma (ESCC), since their role in ESCC is unknown. Me…
View article: SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions
SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions Open
Although selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain unclear. In this study, we defined SELENOP's contributions to sporadic CRC. In hu…
View article: Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells
Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells Open
View article: Eosinophils Exert Antitumorigenic Effects in the Development of Esophageal Squamous Cell Carcinoma
Eosinophils Exert Antitumorigenic Effects in the Development of Esophageal Squamous Cell Carcinoma Open
View article: MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors
MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors Open
Aberrant epithelial differentiation and regeneration contribute to colon pathologies, including inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Myeloid translocation gene 16 (MTG16, also known as CBFA2T3) is a transcr…
View article: MTG16 (CBFA2T3) regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors
MTG16 (CBFA2T3) regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors Open
Aberrant epithelial differentiation and regeneration contribute to colon pathologies including inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). MTG16 (CBFA2T3) is a transcriptional corepressor expressed in the colonic …
View article: Juvenile Selenium Deficiency Impairs Cognition, Sensorimotor Gating, and Energy Homeostasis in Mice
Juvenile Selenium Deficiency Impairs Cognition, Sensorimotor Gating, and Energy Homeostasis in Mice Open
Selenium (Se) is an essential micronutrient of critical importance to mammalian life. Its biological effects are primarily mediated via co-translational incorporation into selenoproteins, as the unique amino acid, selenocysteine. These pro…
View article: Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer
Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer Open
P143 EPITHELIAL-DERIVED SELENOPROTEIN P PROTECTS FROM COLITIS-ASSOCIATED CARCINOGENESIS Open
View article: 993 – Myeloid Translocation Gene on Chromosome 16 (MTG16) is a Transcriptional Co-Repressor that Regulates Epithelial Response to Injury Via Homology Regions Nhr1 and Nhr3
993 – Myeloid Translocation Gene on Chromosome 16 (MTG16) is a Transcriptional Co-Repressor that Regulates Epithelial Response to Injury Via Homology Regions Nhr1 and Nhr3 Open
View article: Trapping redox partnerships in oxidant-sensitive proteins with a small, thiol-reactive cross-linker
Trapping redox partnerships in oxidant-sensitive proteins with a small, thiol-reactive cross-linker Open
View article: Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons
Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons Open
Neurite outgrowth is key to the formation of functional circuits during neuronal development. Neurotrophins, including nerve growth factor (NGF), increase neurite outgrowth in part by altering the function and expression of Ca(2+)-permeabl…