Jennifer O’Neill
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View article: Long-acting Cabotegravir/Rilpivirine for Treatment of HIV During Pregnancy: A Case Series
Long-acting Cabotegravir/Rilpivirine for Treatment of HIV During Pregnancy: A Case Series Open
We present pharmacokinetic data on long-acting cabotegravir/rilpivirine (LA CAB/RPV) from two patients during their second and third trimesters. Monthly LA CAB/RPV dosing maintained concentrations above the proposed efficacy thresholds whi…
View article: Inter‐ and intraindividual variability of long‐acting cabotegravir/rilpivirine pharmacokinetics after 1 year of continuous use
Inter‐ and intraindividual variability of long‐acting cabotegravir/rilpivirine pharmacokinetics after 1 year of continuous use Open
View article: Sustained HIV Viral Suppression 18 Months After the Last Dose of Long-acting Cabotegravir/Rilpivirine: A Case Report
Sustained HIV Viral Suppression 18 Months After the Last Dose of Long-acting Cabotegravir/Rilpivirine: A Case Report Open
Long-acting cabotegravir/rilpivirine offers a low incidence of virologic failure. However, drug resistance can develop after discontinuation without an effective replacement regimen due to its long pharmacokinetic tail. We present a case o…
View article: Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV
Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV Open
Recent work has shown that people with HIV (PWH) exhibit deficits in cognitive control and altered brain responses in the underlying cortical networks, and that regular cannabis use has a normalizing effect on these neural responses. Howev…
View article: Exposure to Secondhand Cannabis Smoke Among Children
Exposure to Secondhand Cannabis Smoke Among Children Open
Importance The degree that in-home cannabis smoking can be detected in the urine of resident children is unclear. Objective Test association of in-home cannabis smoking with urinary cannabinoids in children living at home. Design, Setting,…
View article: Cannabis- and HIV-related perturbations to the cortical gamma dynamics supporting inhibitory processing
Cannabis- and HIV-related perturbations to the cortical gamma dynamics supporting inhibitory processing Open
The main psychoactive component in cannabis—Δ9-tetrahydrocannabinol—is known to have anti-inflammatory properties and to alter gamma oscillations, pointing to its potential as a therapeutic agent for people with HIV (PWH). However, it rema…
View article: People with HIV exhibit spectrally distinct patterns of rhythmic cortical activity serving cognitive flexibility
People with HIV exhibit spectrally distinct patterns of rhythmic cortical activity serving cognitive flexibility Open
Despite effective antiretroviral therapy, cognitive impairment remains prevalent among people with HIV (PWH) and decrements in executive function are particularly prominent. One component of executive function is cognitive flexibility, whi…
View article: Spontaneous cortical activity is altered in persons with HIV and related to domain-specific cognitive function
Spontaneous cortical activity is altered in persons with HIV and related to domain-specific cognitive function Open
Whilst the average lifespan of persons with HIV now approximates that of the general population, these individuals are at a much higher risk of developing cognitive impairment with ∼35–70% experiencing at least subtle cognitive deficits. P…
View article: Clinical markers of HIV predict redox-regulated neural and behavioral function in the sensorimotor system
Clinical markers of HIV predict redox-regulated neural and behavioral function in the sensorimotor system Open
View article: Movement-related beta and gamma oscillations indicate parallels and disparities between Alzheimer's disease and HIV-associated neurocognitive disorder
Movement-related beta and gamma oscillations indicate parallels and disparities between Alzheimer's disease and HIV-associated neurocognitive disorder Open
View article: Resting state network connectivity alterations in <scp>HIV</scp>: Parallels with aging
Resting state network connectivity alterations in <span>HIV</span>: Parallels with aging Open
The increasing incidence of age‐related comorbidities in people with HIV (PWH) has led to accelerated aging theories. Functional neuroimaging research, including functional connectivity (FC) using resting‐state functional magnetic resonanc…
View article: Oscillatory markers of neuroHIV-related cognitive impairment and Alzheimer’s disease during attentional interference processing
Oscillatory markers of neuroHIV-related cognitive impairment and Alzheimer’s disease during attentional interference processing Open
People with HIV (PWH) frequently experience mild cognitive decline, which is typically attributed to HIV-associated neurocognitive disorder (HAND). However, such declines could also be a sign of early Alzheimer's disease (AD) in older PWH.…
View article: An investigation into dietitians’ awareness and recommendations surrounding plant-based diets and plant-based dairy alternatives in Ireland
An investigation into dietitians’ awareness and recommendations surrounding plant-based diets and plant-based dairy alternatives in Ireland Open
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View article: Epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV
Epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV Open
These findings support the concept of interactions between biological aging and HIV status on the neural oscillatory dynamics serving visuospatial processing. Future work should elucidate the long-term trajectory and impact of accelerated …
View article: Regular cannabis use modulates the impact of HIV on the neural dynamics serving cognitive control
Regular cannabis use modulates the impact of HIV on the neural dynamics serving cognitive control Open
Background: Cannabis use and HIV are independently associated with decrements in cognitive control. However, the combined effects of HIV and regular cannabis use on the brain circuitry serving higher-order cognition are unclear. Aims: Inve…
View article: Mitochondrial redox environments predict sensorimotor brain-behavior dynamics in adults with HIV
Mitochondrial redox environments predict sensorimotor brain-behavior dynamics in adults with HIV Open
View article: Convergent and divergent oscillatory aberrations during visuospatial processing in HIV-related cognitive impairment and Alzheimer’s disease
Convergent and divergent oscillatory aberrations during visuospatial processing in HIV-related cognitive impairment and Alzheimer’s disease Open
Adults with HIV frequently develop a form of mild cognitive impairment known as HIV-associated neurocognitive disorder (HAND), but presumably cognitive decline in older persons with HIV could also be attributable to Alzheimer’s disease (AD…
View article: Signatures of somatosensory cortical dysfunction in Alzheimer’s disease and HIV-associated neurocognitive disorder
Signatures of somatosensory cortical dysfunction in Alzheimer’s disease and HIV-associated neurocognitive disorder Open
Alzheimer’s disease is the most common type of dementia in the general population, while HIV-associated neurocognitive disorder is the most common neurological comorbidity in those infected with HIV and affects between 40 and 70% of this p…
View article: Cannabis use impacts pre‐stimulus neural activity in the visual cortices of people with <scp>HIV</scp>
Cannabis use impacts pre‐stimulus neural activity in the visual cortices of people with <span>HIV</span> Open
People with HIV (PWH) use cannabis at a higher rate than the general population, but the influence on neural activity is not well characterized. Cannabis use among PWH may have a beneficial effect, as neuroinflammation is known to be a cri…
View article: Neuroinflammatory profiles regulated by the redox environment predicted cognitive dysfunction in people living with HIV: A cross-sectional study
Neuroinflammatory profiles regulated by the redox environment predicted cognitive dysfunction in people living with HIV: A cross-sectional study Open
National Institute of Mental Health, National Institute for Neurological Disorders and Stroke, National Institute on Drug Abuse, National Science Foundation.
View article: Impact of <scp>HIV‐infection</scp> on human somatosensory processing, spontaneous cortical activity, and cortical thickness: A multimodal neuroimaging approach
Impact of <span>HIV‐infection</span> on human somatosensory processing, spontaneous cortical activity, and cortical thickness: A multimodal neuroimaging approach Open
HIV‐infection has been associated with widespread alterations in brain structure and function, although few studies have examined whether such aberrations are co‐localized and the degree to which clinical and cognitive metrics are related.…
View article: Reductions in Gray Matter Linked to Epigenetic HIV-Associated Accelerated Aging
Reductions in Gray Matter Linked to Epigenetic HIV-Associated Accelerated Aging Open
A growing literature suggests a relationship between HIV-infection and a molecular profile of age acceleration. However, despite the widely known high prevalence of HIV-related brain atrophy and HIV-associated neurocognitive disorder (HAND…
View article: Gray matter volumes discriminate cognitively impaired and unimpaired people with HIV
Gray matter volumes discriminate cognitively impaired and unimpaired people with HIV Open
View article: The age-related trajectory of visual attention neural function is altered in adults living with HIV: A cross-sectional MEG study
The age-related trajectory of visual attention neural function is altered in adults living with HIV: A cross-sectional MEG study Open
View article: Association of Epigenetic Metrics of Biological Age With Cortical Thickness
Association of Epigenetic Metrics of Biological Age With Cortical Thickness Open
To our knowledge, this is the first study to investigate vertexwise cortical thickness in relation to DNAm-based biological age, and the findings suggest that this metric of biological age may yield additional insight on healthy and pathol…
View article: Surprisingly Low Levels of Measles Immunity in Persons With HIV: A Seroprevalence Survey in a United States HIV Clinic
Surprisingly Low Levels of Measles Immunity in Persons With HIV: A Seroprevalence Survey in a United States HIV Clinic Open
Background Measles outbreaks have become increasingly common due to deteriorating vaccination rates, fluctuating herd immunity, and varying antibody decline. Limited knowledge exists regarding prevalence and risk factors associated with me…
View article: Clinical Experience with COVID-19 at a Specialty Orthopedic Hospital Converted to a Pandemic Overflow Field Hospital
Clinical Experience with COVID-19 at a Specialty Orthopedic Hospital Converted to a Pandemic Overflow Field Hospital Open
Background COVID-19, the illness caused by the novel coronavirus, SARS-CoV-2, has sickened millions and killed hundreds of thousands as of June 2020. New York City was affected gravely. Our hospital, a specialty orthopedic hospital unaccus…
View article: Incidental Findings on Brain MRI in People with HIV Infection
Incidental Findings on Brain MRI in People with HIV Infection Open
View article: Age-related visual dynamics in HIV-infected adults with cognitive impairment
Age-related visual dynamics in HIV-infected adults with cognitive impairment Open
Impaired HIV-infected participants exhibited markedly different relationships between age and neural responses in the parieto-occipital cortices relative to their peers. This suggests a differential effect of chronological aging on the neu…
View article: Prefrontal gating of sensory input differentiates cognitively impaired and unimpaired aging adults with HIV
Prefrontal gating of sensory input differentiates cognitively impaired and unimpaired aging adults with HIV Open
Despite effective therapies that have extended the life expectancy of persons living with HIV, 35–70% of these adults still develop some form of cognitive impairment, and with a growing population of aging adults with HIV, the prevalence o…