Jennifer P. Kitzmann
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View article: Silicone rubber membrane devices permit islet culture at high density without adverse effects
Silicone rubber membrane devices permit islet culture at high density without adverse effects Open
Introduction Conventional culture conditions, such as in T-flasks, require that oxygen diffuse through the medium to reach the islets; in turn, islet surface area density is limited by oxygen availability. To culture a typical clinical isl…
View article: Islet Harvest in Carbon Monoxide-Saturated Medium for Chronic Pancreatitis Patients Undergoing Islet Autotransplantation
Islet Harvest in Carbon Monoxide-Saturated Medium for Chronic Pancreatitis Patients Undergoing Islet Autotransplantation Open
Stresses encountered during human islet isolation lead to unavoidable β-cell death after transplantation. This reduces the chance of insulin independence in chronic pancreatitis patients undergoing total pancreatectomy and islet autotransp…
View article: Acute Ischemia Induced by High-Density Culture Increases Cytokine Expression and Diminishes the Function and Viability of Highly Purified Human Islets of Langerhans
Acute Ischemia Induced by High-Density Culture Increases Cytokine Expression and Diminishes the Function and Viability of Highly Purified Human Islets of Langerhans Open
In order for cell-based insulin replacement to be applied as a treatment for type 1 diabetes, oxygen and nutrient delivery to β cells will need to be maintained. We demonstrate that even brief ischemic exposure such as would be experienced…
View article: Noninvasive assessment of tissue‐engineered graft viability by oxygen‐17 magnetic resonance spectroscopy
Noninvasive assessment of tissue‐engineered graft viability by oxygen‐17 magnetic resonance spectroscopy Open
Transplantation of macroencapsulated tissue‐engineered grafts (TEGs) is being investigated as a treatment for type 1 diabetes, but there is a critical need to measure TEG viability both in vitro and in vivo. Oxygen deficiency is the most c…
View article: Continuous Quadrupole Magnetic Separation of Islets during Digestion Improves Purified Porcine Islet Viability
Continuous Quadrupole Magnetic Separation of Islets during Digestion Improves Purified Porcine Islet Viability Open
Islet transplantation (ITx) is an emerging and promising therapy for patients with uncontrolled type 1 diabetes. The islet isolation and purification processes require exposure to extended cold ischemia, warm-enzymatic digestion, mechanica…