Jennifer R. Habel
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View article: Academic leadership careers are not limited to scientific research
Academic leadership careers are not limited to scientific research Open
Early career researchers (ECRs) are often faced with uncertainty about their professional futures, a challenge exacerbated by the increasing pressures within the academic research landscape. As ECRs navigate their next steps in science, me…
View article: HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes
HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes Open
Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in n…
View article: Academic leadership careers are not limited to scientific research
Academic leadership careers are not limited to scientific research Open
View article: Single-cell immune profiling of third trimester pregnancies defines importance of chemokine receptors and prevalence of CMV-induced NK cells in the periphery and decidua
Single-cell immune profiling of third trimester pregnancies defines importance of chemokine receptors and prevalence of CMV-induced NK cells in the periphery and decidua Open
Human pregnancy presents a unique physiological state that allows for growth of an antigenically dissimilar foetus and requires specific adaptations of the immune system. The immune system plays an important role in establishing and mainta…
View article: SARS-CoV-2-specific CD8 <sup>+</sup> T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years
SARS-CoV-2-specific CD8 <sup>+</sup> T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years Open
Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. SARS-Co…
View article: High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases
High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases Open
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning fatal dis…
View article: Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations
Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations Open
NK and T cells perturbations in pregnancy
View article: Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells
Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells Open
View article: Robust SARS-CoV-2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments
Robust SARS-CoV-2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments Open
View article: Robust SARS-CoV-2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments
Robust SARS-CoV-2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments Open
BACKGROUND AND AIMS Vaccine-mediated immune responses in patients with inflammatory bowel disease (IBD) may be influenced by IBD therapies. We investigated in-depth humoral and T-cell responses to SARS-CoV-2 vaccination in IBD patients fol…
View article: Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques
Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques Open
Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their efficacy can be modest, especially in immunologically-naïve individuals. We investigated immune responses towards…
View article: SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity Open
View article: T Cell Epitope Discovery in the Context of Distinct and Unique Indigenous HLA Profiles
T Cell Epitope Discovery in the Context of Distinct and Unique Indigenous HLA Profiles Open
CD8 + T cells are a pivotal part of the immune response to viruses, playing a key role in disease outcome and providing long-lasting immunity to conserved pathogen epitopes. Understanding CD8 + T cell immunity in humans is complex due to C…
View article: Immunization with inactivated whole virus particle influenza virus vaccines induces superior immunity in cynomolgus macaques
Immunization with inactivated whole virus particle influenza virus vaccines induces superior immunity in cynomolgus macaques Open
Influenza viruses circulate globally, causing seasonal influenza outbreaks. Although antibody-inducing vaccines are the most effective way to combat seasonal infections, current vaccines can have poor efficacy, especially in children and i…
View article: HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people
HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people Open
HLA-A*11:01 is one of the most prevalent human leukocyte antigens (HLAs), especially in East Asian and Oceanian populations. It is also highly expressed in Indigenous people who are at high risk of severe influenza disease. As CD8 + T cell…
View article: Are NKT cells a useful predictor of COVID-19 severity?
Are NKT cells a useful predictor of COVID-19 severity? Open
View article: Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity
Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity Open
Although the respiratory tract is the primary site of SARS-CoV-2 infection and the ensuing immunopathology, respiratory immune responses are understudied and urgently needed to understand mechanisms underlying COVID-19 disease pathogenesis…
View article: Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity
Immune responses in COVID-19 respiratory tract and blood reveal mechanisms of disease severity Open
Although the respiratory tract is the primary site of SARS-CoV-2 infection and the ensuing immunopathology, respiratory immune responses are understudied and urgently needed to understand mechanisms underlying COVID-19 disease pathogenesis…
View article: Integrated immune networks in SARS-CoV-2 infected pregnant women reveal differential NK cell and unconventional T cell activation
Integrated immune networks in SARS-CoV-2 infected pregnant women reveal differential NK cell and unconventional T cell activation Open
Although pregnancy poses a greater risk for severe COVID-19, the underlying immunological changes associated with SARS-CoV-2 infection during pregnancy are poorly understood. We defined immune responses to SARS-CoV-2 in pregnant and non-pr…
View article: CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity
CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity Open
View article: Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses Open
View article: Robust correlations across six SARS‐CoV‐2 serology assays detecting distinct antibody features
Robust correlations across six SARS‐CoV‐2 serology assays detecting distinct antibody features Open
Objectives As the world transitions into a new era of the COVID‐19 pandemic in which vaccines become available, there is an increasing demand for rapid reliable serological testing to identify individuals with levels of immunity considered…
View article: Suboptimal SARS-CoV-2−specific CD8 <sup>+</sup> T cell response associated with the prominent HLA-A*02:01 phenotype
Suboptimal SARS-CoV-2−specific CD8 <sup>+</sup> T cell response associated with the prominent HLA-A*02:01 phenotype Open
Significance As the recall of CD8 + T cell memory promotes rapid recovery in, for example, influenza, we investigated circulating SARS-CoV-2−specific CD8 + T cells from COVID-19 patients. For two HLA-A*02:01 SARS-CoV-2−specific CD8 + T cel…
View article: Suboptimal SARS-CoV-2-specific CD8<sup>+</sup> T-cell response associated with the prominent HLA-A*02:01 phenotype
Suboptimal SARS-CoV-2-specific CD8<sup>+</sup> T-cell response associated with the prominent HLA-A*02:01 phenotype Open
An improved understanding of human T-cell-mediated immunity in COVID-19 is important if we are to optimize therapeutic and vaccine strategies. Experience with influenza shows that infection primes CD8 + T-cell memory to shared peptides pre…
View article: High Precursor Frequency and Promiscuity in Αβ T Cell Receptor Pairing Underpin CD8+ T-Cell Responses to an Immunodominant SARS-CoV-2 Nucleocapsid Epitope
High Precursor Frequency and Promiscuity in Αβ T Cell Receptor Pairing Underpin CD8+ T-Cell Responses to an Immunodominant SARS-CoV-2 Nucleocapsid Epitope Open
View article: Re: Integrated Immune Dynamics Define Correlates of COVID-19 Severity and Antibody Responses
Re: Integrated Immune Dynamics Define Correlates of COVID-19 Severity and Antibody Responses Open