Jennifer M. Reinhart
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View article: Multiple diagnostic modalities are appropriate for detecting Nannizziopsis guarroi in experimentally infected bearded dragons (Pogona vitticeps)
Multiple diagnostic modalities are appropriate for detecting Nannizziopsis guarroi in experimentally infected bearded dragons (Pogona vitticeps) Open
Introduction Nannizziopsis guarroi causes mycotic dermatitis, colloquially known as “yellow fungus disease”, in lizards. Several fungal diagnostic assays may detect this microbe in clinical cases, but the clinical performance of these assa…
View article: Single‐Dose, Intravenous, and Oral Pharmacokinetics of Isavuconazole in Dogs
Single‐Dose, Intravenous, and Oral Pharmacokinetics of Isavuconazole in Dogs Open
Isavuconazole, a triazole antifungal used in humans for invasive fungal infections, may be effective for treating canine fungal infections, although data on its use in dogs is limited. This study aimed to determine the pharmacokinetics and…
View article: The Single‐Dose Pharmacokinetics of a Compounded Levetiracetam Formulation and Bioequivalence to a Commercial Formulation in Healthy Dogs
The Single‐Dose Pharmacokinetics of a Compounded Levetiracetam Formulation and Bioequivalence to a Commercial Formulation in Healthy Dogs Open
Levetiracetam (LEV) is an anti‐epileptic drug used extra‐label in dogs. Commercially available extended‐release formulations (LEV‐ER), administered twice daily, cannot be crushed or split, limiting their use in small dogs. A compounded LEV…
View article: Clinical features of tularemia in cats: a retrospective study from 2000 to 2021
Clinical features of tularemia in cats: a retrospective study from 2000 to 2021 Open
Objectives The objectives of this study were to describe the clinical features of cats diagnosed with tularemia, and to compare the clinical features of cats with and without tularemia and identify characteristics increasing the likelihood…
View article: Digital Immunoassay for Rapid Detection of SARS-CoV-2 Infection in a Broad Spectrum of Animals
Digital Immunoassay for Rapid Detection of SARS-CoV-2 Infection in a Broad Spectrum of Animals Open
The ability of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) to infect a wide-range of species raises significant concerns regarding both human-to-animal and animal-to-human transmission. There is an increasing demand for hi…
View article: Case series of dogs with blastomycosis managed with high-flow nasal oxygen therapy (2019–2023): 19 cases
Case series of dogs with blastomycosis managed with high-flow nasal oxygen therapy (2019–2023): 19 cases Open
Objective To describe the clinical presentation, progression, treatment, and outcome of dogs with blastomycosis treated with high-flow nasal oxygen therapy (HFNOT). Design Retrospective case review. Setting University veterinary teaching h…
View article: Spatial and temporal clustering of anti-SARS-CoV-2 antibodies in Illinois household cats, 2021–2023
Spatial and temporal clustering of anti-SARS-CoV-2 antibodies in Illinois household cats, 2021–2023 Open
This study aimed to evaluate the seroprevalence and spatial and temporal clustering of SARS-CoV-2 antibodies in household cats within 63 counties in Illinois from October 2021 to May 2023. The analysis followed a stepwise approach. First, …
View article: Assessing the urinary concentration of nitrofurantoin and its antibacterial activity against Escherichia coli, Staphylococcus pseudintermedius, and Enterococcus faecium isolated from dogs with urinary tract infections
Assessing the urinary concentration of nitrofurantoin and its antibacterial activity against Escherichia coli, Staphylococcus pseudintermedius, and Enterococcus faecium isolated from dogs with urinary tract infections Open
Nitrofurantoin, a broad-spectrum nitrofuran class antibiotic, is applied as a first-line antibiotic in treating human urinary tract infections (UTIs) due to its great efficacy and high achievable concentration. The interest in using this a…
View article: Development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals
Development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals Open
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant threat to public health. Besides humans, SARS-CoV-2 can infect several animal species. Highly sensitive and specific diagnostic reagent…
View article: Spatial and temporal clustering of anti-SARS-CoV-2 antibodies in Illinois household cats, 2021-2023
Spatial and temporal clustering of anti-SARS-CoV-2 antibodies in Illinois household cats, 2021-2023 Open
This study evaluated the seroprevalence of SARS-CoV-2 antibodies in Illinois household cats from October 2021 to May 2023. Among 1,715 samples tested by serological assays, 244 samples (14%) tested positive. High-rate temporal, spatial, an…
View article: Pharmacokinetic, sedative, and physiological effects of oral compounded formulations of trazodone alone or in combination with gabapentin in male cats
Pharmacokinetic, sedative, and physiological effects of oral compounded formulations of trazodone alone or in combination with gabapentin in male cats Open
Trazodone and gabapentin are common oral sedatives in cats, used alone or combined, but no pharmacokinetic studies exist for trazodone in this species. The objective of this study was to determine the pharmacokinetics of oral trazodone (T)…
View article: Development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals
Development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals Open
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant threat to public health. Besides humans, SARS-CoV-2 can infect several animal species. Highly sensitive and specific diagnostic reagent…
View article: Bioencapsulation is a feasible method of terbinafine administration in Emydomyces testavorans-infected western pond turtles (Actinemys marmorata)
Bioencapsulation is a feasible method of terbinafine administration in Emydomyces testavorans-infected western pond turtles (Actinemys marmorata) Open
OBJECTIVE To evaluate the pharmacokinetics of terbinafine administered to western pond turtles ( Actinemys marmorata ) via oral gavage and bioencapsulated in earthworms. ANIMALS 7 western pond turtles. PROCEDURES A randomized complete cros…
View article: Single‐dose pharmacokinetics of telmisartan oral solution and effect of feeding in dogs
Single‐dose pharmacokinetics of telmisartan oral solution and effect of feeding in dogs Open
Telmisartan is an angiotensin II receptor blocker that has great potential to improve the treatment of hypertension, proteinuria, and cardiovascular disease in dogs. A feline‐approved telmisartan oral solution (TOS) is available, but this …
View article: Longitudinal analysis of the rectal microbiome in dogs with diabetes mellitus after initiation of insulin therapy
Longitudinal analysis of the rectal microbiome in dogs with diabetes mellitus after initiation of insulin therapy Open
There have been numerous studies in humans and rodents substantiating the role of the gastrointestinal microbiome in the pathogenesis and progression of both type 1 and type 2 diabetes mellitus. Diabetes mellitus is a common endocrinopathy…
View article: Pharmacokinetics of a 503B outsourcing facility-produced theophylline in dogs
Pharmacokinetics of a 503B outsourcing facility-produced theophylline in dogs Open
Theophylline is an important drug for treatment of canine chronic bronchitis and bradyarrhythmias, but new products require validation since pharmacokinetics in dogs can vary by formulation. A new, 503B outsourcing facility-produced theoph…
View article: Single-dose pharmacokinetics of orally administered terbinafine in bearded dragons (Pogona vitticeps) and the antifungal susceptibility patterns of Nannizziopsis guarroi
Single-dose pharmacokinetics of orally administered terbinafine in bearded dragons (Pogona vitticeps) and the antifungal susceptibility patterns of Nannizziopsis guarroi Open
OBJECTIVE To identify the antifungal susceptibility of Nanniziopsis guarroi isolates and to evaluate the single-dose pharmacokinetics of orally administered terbinafine in bearded dragons. ANIMALS 8 healthy adult bearded dragons. PROCEDURE…
View article: Cytotoxicity of Cultured Canine Primary Hepatocytes Exposed to Itraconazole Is Decreased by Pre-treatment With Glutathione
Cytotoxicity of Cultured Canine Primary Hepatocytes Exposed to Itraconazole Is Decreased by Pre-treatment With Glutathione Open
Objective: To identify the effect of glutathione (GSH) on cell survival in a novel in vitro model of itraconazole (ITZ)-associated hepatotoxicity using canine primary hepatocytes. Sample: Commercially sourced, cryopreserved male dog (Beagl…
View article: Feasibility of hepatic fine needle aspiration as a minimally invasive sampling method for gene expression quantification of pharmacogenetic targets in dogs
Feasibility of hepatic fine needle aspiration as a minimally invasive sampling method for gene expression quantification of pharmacogenetic targets in dogs Open
Background Quantifying hepatic gene expression is important for many pharmacogenetic studies. However, this usually requires biopsy (BX), which is invasive. Objectives The objectives of this study were to determine the feasibility of using…
View article: Serum levetiracetam concentrations after transdermal levetiracetam administration, 3 times daily, to healthy cats
Serum levetiracetam concentrations after transdermal levetiracetam administration, 3 times daily, to healthy cats Open
Background Repeated oral administration of antiepileptic drugs can be challenging for cat owners, resulting in reduced compliance, poor seizure control, and reduced quality of life for cats. Levetiracetam (LEV) has several properties that …
View article: RNA expression profiling in sulfamethoxazole‐treated patients with a range of in vitro lymphocyte cytotoxicity phenotypes
RNA expression profiling in sulfamethoxazole‐treated patients with a range of in vitro lymphocyte cytotoxicity phenotypes Open
The lymphocyte toxicity assay ( LTA ) is a proposed surrogate marker of sulfonamide antibiotic hypersensitivity. In the LTA , peripheral blood mononuclear cells ( PBMC s) undergo apoptosis more readily in hypersensitive versus tolerant pat…
View article: Genome-Wide Association Study in Immunocompetent Patients with Delayed Hypersensitivity to Sulfonamide Antimicrobials
Genome-Wide Association Study in Immunocompetent Patients with Delayed Hypersensitivity to Sulfonamide Antimicrobials Open
No convincing genetic risk factors for sulfonamide HS were identified in this population. These negative findings may be due to challenges in accurately confirming the phenotype in exanthematous drug eruptions, or to unidentified gene-envi…
View article: Derangements of tonicity and implications for veterinary patients
Derangements of tonicity and implications for veterinary patients Open
View article: Evaluation of mean corpuscular volume difference as a marker for serum hypertonicity during water deprivation in dogs
Evaluation of mean corpuscular volume difference as a marker for serum hypertonicity during water deprivation in dogs Open
OBJECTIVE To evaluate mean corpuscular volume difference (dMCV) as a marker for hypertonicity induced by water deprivation in dogs. ANIMALS 5 healthy Greyhounds maintained in a research colony. PROCEDURES Water was withheld for 24 hours. B…