Jennifer Romanowicz
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View article: Estimation of pre-Fontan pulmonary vascular resistance in children with single ventricle heart disease at the Glenn stage: a multicenter study
Estimation of pre-Fontan pulmonary vascular resistance in children with single ventricle heart disease at the Glenn stage: a multicenter study Open
The Fontan procedure, employed in the management of children with single ventricle congenital heart disease, continues to present long-term complications. Notably, certain complications associated with this procedure are linked to imbalanc…
View article: Magnetic resonance quantification of regional blood flow and oxygen delivery to the brain, gut, kidneys, and lower extremities in adolescents with a Fontan circulation compared to biventricular controls
Magnetic resonance quantification of regional blood flow and oxygen delivery to the brain, gut, kidneys, and lower extremities in adolescents with a Fontan circulation compared to biventricular controls Open
Our results are consistent with a limited flow reserve in the Fontan circulation with sacrifice of iliac arterial flow as global systemic blood flow decreases. Importantly, these data were measured with subjects supine and at rest. Future …
View article: Determination of individual lung pulmonary vascular resistance in children with glenn physiology: A two-center study
Determination of individual lung pulmonary vascular resistance in children with glenn physiology: A two-center study Open
View article: Perturbations of tryptophan catabolism via the kynurenine pathway are associated with stage 2 postoperative outcomes in single ventricle heart disease
Perturbations of tryptophan catabolism via the kynurenine pathway are associated with stage 2 postoperative outcomes in single ventricle heart disease Open
Preliminary evidence suggests perturbations of the kynurenine pathway (KP) of tryptophan metabolism in infants with single ventricle heart disease (SVHD). In 72 infants with SVHD undergoing stage 2 palliation (S2P) and 41 controls, we quan…
View article: Estimation of pulmonary vascular resistance for Glenn physiology
Estimation of pulmonary vascular resistance for Glenn physiology Open
Children with single ventricle heart disease typically require a series of three operations, (1) Norwood, (2) Glenn, and (3) Fontan, which ultimately results in complete separation of the pulmonary and systemic circuits to improve pulmonar…
View article: HVSMR-2.0: A 3D cardiovascular MR dataset for whole-heart segmentation in congenital heart disease
HVSMR-2.0: A 3D cardiovascular MR dataset for whole-heart segmentation in congenital heart disease Open
View article: Utilization of T2 Prep for MR Oximetery Combined with 4D Flow Phase Contrast Imaging for Evaluation of Extracardiac Organ Oxygen Metabolism in Fontan Patients
Utilization of T2 Prep for MR Oximetery Combined with 4D Flow Phase Contrast Imaging for Evaluation of Extracardiac Organ Oxygen Metabolism in Fontan Patients Open
View article: Estimation of Pulmonary Vascular Resistance of Children with Single Ventricle in Glenn Physiology
Estimation of Pulmonary Vascular Resistance of Children with Single Ventricle in Glenn Physiology Open
View article: Aortic arch shape after arch repair predicts exercise capacity: a multicentre analysis
Aortic arch shape after arch repair predicts exercise capacity: a multicentre analysis Open
Aims Coarctation of the aorta is associated with long-term morbidity including decreased exercise capacity, despite successful repair. In the absence of discrete recoarctation, the haemodynamic mechanism remains unknown. This multicentre s…
View article: Automated segmentation of 3D cine cardiovascular magnetic resonance imaging
Automated segmentation of 3D cine cardiovascular magnetic resonance imaging Open
Introduction As the life expectancy of children with congenital heart disease (CHD) is rapidly increasing and the adult population with CHD is growing, there is an unmet need to improve clinical workflow and efficiency of analysis. Cardiov…
View article: Cardiac magnetic resonance parameters associated with successful conversion from a single ventricular to a one-and-a-half or biventricular circulation in patients with a hypoplastic right ventricle
Cardiac magnetic resonance parameters associated with successful conversion from a single ventricular to a one-and-a-half or biventricular circulation in patients with a hypoplastic right ventricle Open
We identified multiple CMR parameters associated with successful conversion from 1 V circulation to 1.5 V or 2 V circulation in patients with PA/IVS and LDAVC. This information may improve patient selection for conversion procedures and en…
View article: Non-contrast free-breathing whole-heart 3D cine cardiovascular magnetic resonance with a novel 3D radial leaf trajectory
Non-contrast free-breathing whole-heart 3D cine cardiovascular magnetic resonance with a novel 3D radial leaf trajectory Open
View article: Predicting Cardiac Anatomy, Physiology, and Surgical Management Based on Fetal Echocardiography in Heterotaxy Syndrome
Predicting Cardiac Anatomy, Physiology, and Surgical Management Based on Fetal Echocardiography in Heterotaxy Syndrome Open
Objective Heterotaxy syndrome (HS) is often associated with complex congenital heart disease (CHD). While fetal echocardiography (FE) permits accurate prenatal identification of most CHD, the high level of disease complexity in HS may pose…
View article: Accelerated free-breathing 3D whole-heart magnetic resonance angiography with a radial phyllotaxis trajectory, compressed sensing, and curvelet transform
Accelerated free-breathing 3D whole-heart magnetic resonance angiography with a radial phyllotaxis trajectory, compressed sensing, and curvelet transform Open
View article: Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease
Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease Open
We utilized a new mouse model of chronic perinatal hypoxia to simulate the hypoxic myocardial conditions present in cyanotic congenital heart disease. Hypoxia caused numerous abnormalities in cardiomyocyte gene expression, the electrophysi…
View article: Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease
Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease Open
Background Compared to acyanotic congenital heart disease (CHD), cyanotic CHD has an increased risk of lifelong mortality and morbidity. These adverse outcomes may be attributed to delayed cardiomyocyte maturation, since the transition fro…
View article: Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease
Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease Open
Background Reduced oxygen delivery in congenital heart disease causes delayed brain maturation and white matter abnormalities in utero. No treatment currently exists. Tetrahydrobiopterin ( BH 4) is a cofactor for neuronal nitric oxide synt…