Jennifer S. Yokoyama
YOU?
Author Swipe
View article: The role of genomic‐informed risk assessments in predicting dementia outcomes
The role of genomic‐informed risk assessments in predicting dementia outcomes Open
INTRODUCTION By integrating genetic and clinical risk factors into genomic‐informed dementia risk reports, healthcare providers can offer patients detailed risk profiles to facilitate understanding of individual risk and support the implem…
View article: Identifying sex‐ and gender‐specific endocrinological, lifestyle, psychosocial, and socio‐cultural targets for Alzheimer's disease prevention in Africans: The Female Brain Health and Endocrine Research in Africa (FemBER‐Africa) project
Identifying sex‐ and gender‐specific endocrinological, lifestyle, psychosocial, and socio‐cultural targets for Alzheimer's disease prevention in Africans: The Female Brain Health and Endocrine Research in Africa (FemBER‐Africa) project Open
Dementia rates are rising globally, with the burden increasing most rapidly in low‐ to middle‐income countries. Despite this, research into Alzheimer's disease and related dementias (ADRD) among African populations remains limited, with ex…
View article: Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer’s Disease Risk Prediction in Multiethnic Cohorts
Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer’s Disease Risk Prediction in Multiethnic Cohorts Open
INTRODUCTION Genome-wide association studies (GWAS) have identified 80+ genetic loci associated with Alzheimer’s disease (AD), enabling the development of polygenic risk scores (PRS). However, the predictive accuracy of PRS in diverse popu…
View article: Random forest model improves annotation and discovery of variants of uncertain significance in Alzheimer’s and other neurological disorders
Random forest model improves annotation and discovery of variants of uncertain significance in Alzheimer’s and other neurological disorders Open
Variants of uncertain significance (VUS) are a bottleneck for genetic discovery and complicate clinical decision-making in Alzheimer’s disease and related neurological disorders (ADRD). We developed MoVUS: Model for Variants of Unknown Sig…
View article: Cardiovascular risk factors and the allostatic interoceptive network in dementia
Cardiovascular risk factors and the allostatic interoceptive network in dementia Open
Aims Cardiovascular risk factors, such diabetes, hypertension, blood pressure, obesity, and smoking, are linked with allostatic-interoception—the continuous monitoring of internal bodily states in anticipation of environmental demands. The…
View article: Functional Connectivity Associations With Markers of Disease Progression in <i>GRN</i> Pathogenic Variant Carriers
Functional Connectivity Associations With Markers of Disease Progression in <i>GRN</i> Pathogenic Variant Carriers Open
Objective Autosomal dominant progranulin ( GRN ) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN ‐related therapies are underway, there is an unmet need for biomarkers that can p…
View article: Social exposome and brain health outcomes of dementia across Latin America
Social exposome and brain health outcomes of dementia across Latin America Open
A multidimensional social exposome (MSE)—the combined lifespan measures of education, food insecurity, financial status, access to healthcare, childhood experiences, and more—may shape dementia risk and brain health over the lifespan, part…
View article: Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype
Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype Open
INTRODUCTION Risk factors associated with sporadic non‐amnestic and early‐onset Alzheimer's disease (AD) remain underexamined. METHODS We investigated a large, clinically heterogeneous, AD cohort for frequencies of established risk factors…
View article: White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study
White matter hyperintensities and their impact in brain structure and function in alzheimer’s disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study Open
Background White matter hyperintensities (WMHs) are a core manifestation of normal and pathological aging and are potentially linked to geographical differences in social and physical exposomes. Previous studies have not examined the impac…
View article: Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD
Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD Open
Genetic mutations in the progranulin gene, GRN , cause frontotemporal dementia and a lysosomal storage disorder. Using single-nuclei RNA sequencing of the post-mortem brain tissue from adult heterozygous pathogenic granulin variant ( GRN +…
View article: Genetic Contributions to Alzheimer's Disease and Frontotemporal Dementia in Admixed Latin American Populations
Genetic Contributions to Alzheimer's Disease and Frontotemporal Dementia in Admixed Latin American Populations Open
Latin America's diverse genetic landscape provides a unique opportunity to study Alzheimer's disease (AD) and frontotemporal dementia (FTD). The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat) recruited 2,162…
View article: Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing Open
Frontotemporal lobar degeneration with neuronal inclusions of the TAR DNA-binding protein 43 (FTLD-TDP) is a fatal neurodegenerative disorder with only a limited number of risk loci identified. We report our comprehensive genome-wide assoc…
View article: <i>BDNF</i> Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults
<i>BDNF</i> Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults Open
INTRODUCTION Increased brain‐derived neurotrophic factor (BDNF) release through physical activity (PA) is thought to underlie protective effects of PA on brain aging. The BDNF Val66Met single‐nucleotide polymorphism (rs6265) reduces activi…
View article: Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates escape of the silent X chromosome in the female mouse hippocampus Open
Women live longer than men and exhibit less cognitive aging. The X chromosome contributes to sex differences, as females harbor an inactive X (Xi) and active X (Xa), in contrast to males with only an Xa. Thus, reactivation of silent Xi gen…
View article: Exploring Peripheral Blood Biomarkers for Dementia Diagnosis in Latin American Populations
Exploring Peripheral Blood Biomarkers for Dementia Diagnosis in Latin American Populations Open
Background Dementia, encompassing Alzheimer's disease (AD) and frontotemporal dementia (FTD), poses a substantial public health challenge in Latin America. Barriers such as a shortage of healthcare professionals, limited medical accessibil…
View article: Genetic factors affect tau deposition in entorhinal cortex and neocortex
Genetic factors affect tau deposition in entorhinal cortex and neocortex Open
Background The amyloid cascade hypothesis posits a sequence of events proceeding from amyloid‐β (Aβ) deposition to entorhinal cortical (EC) tau to neocortical (meta‐temporal) tau. This study examined how genetics may modify relationships b…
View article: Evaluating the Impact of Combined Clinical and Genetic Risk Factors on Dementia Onset
Evaluating the Impact of Combined Clinical and Genetic Risk Factors on Dementia Onset Open
Background Integrating clinical and genetic risk factors for dementia in a precision medicine framework can play a crucial role in primary prevention. Here, we ascertained the proportion of individuals who are at heightened risk of develop…
View article: Predicting Neurodegenerative Diseases: Unveiling the Interplay of Genetics and Social Determinants
Predicting Neurodegenerative Diseases: Unveiling the Interplay of Genetics and Social Determinants Open
Background Predicting Alzheimer's disease (AD) and frontotemporal dementia (FTD) using polygenic risk scores (PRS) for late‐onset forms holds promise, but its accuracy might be influenced by social determinants of health (SDOH). This study…
View article: Functional connectivity associations with markers of disease progression in <i>GRN</i> mutation carriers
Functional connectivity associations with markers of disease progression in <i>GRN</i> mutation carriers Open
Background Autosomal dominant progranulin ( GRN) mutations are a common genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN ‐related therapies are underway, there is an unmet need for biomarkers that can pred…
View article: Asian Cohort for Alzheimer’s Disease (ACAD) Study on Genetic and Non‐Genetic Risk Factors for Alzheimer’s Disease among Asian Americans and Canadians
Asian Cohort for Alzheimer’s Disease (ACAD) Study on Genetic and Non‐Genetic Risk Factors for Alzheimer’s Disease among Asian Americans and Canadians Open
Background Asian Americans and Asian Canadians (ASACs) are the fastest growing minority group in the US and Canada. However, ASACs are under‐sampled in Alzheimer’s disease (AD) research. To address the need of culturally appropriate clinic…
View article: The Female Brain Health and Endocrine Research in Africa Study (FemBER‐AFRICA): Identifying endocrinological, lifestyle, psychosocial and socio‐cultural targets for Alzheimer’s disease prevention in women of African ancestry
The Female Brain Health and Endocrine Research in Africa Study (FemBER‐AFRICA): Identifying endocrinological, lifestyle, psychosocial and socio‐cultural targets for Alzheimer’s disease prevention in women of African ancestry Open
Background The Global Dementia Action Plan 2017‐2025 specifies key targets, with an emphasis on building research infrastructure and capability across the Global South. However, to date, only 0.1% of total research in Africa constitutes de…