Jennifer J. Ware
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View article: Large-scale screening of clinical assessments to distinguish between states in the Integrated HD Progression Model (IHDPM)
Large-scale screening of clinical assessments to distinguish between states in the Integrated HD Progression Model (IHDPM) Open
Background Understanding the sensitivity and utility of clinical assessments across different HD stages is important for study/trial endpoint selection and clinical assessment development. The Integrated HD Progression Model (IHDPM) charac…
View article: Incidence of completed suicide and suicide attempts in a global prospective study of Huntington's disease
Incidence of completed suicide and suicide attempts in a global prospective study of Huntington's disease Open
Background Risk of death from suicide in Huntington's disease is notably elevated relative to that in the general population, although the incidence within HD populations has not been precisely defined. Robust incidence estimates of suicid…
View article: Utility of Huntington's Disease Assessments by Disease Stage: Floor/Ceiling Effects
Utility of Huntington's Disease Assessments by Disease Stage: Floor/Ceiling Effects Open
Introduction: An understanding of the clinimetric properties of clinical assessments, including their constraints, is critical to sound clinical study and trial design. Utilizing data from Enroll-HD—a global, prospective HD observational s…
View article: An evaluation of Cochrane Crowd found that crowdsourcing produced accurate results in identifying randomized trials
An evaluation of Cochrane Crowd found that crowdsourcing produced accurate results in identifying randomized trials Open
Cochrane Crowd is sufficiently accurate and scalable to keep pace with the current rate of publication (and registration) of new primary studies. It has also proved to be a popular, efficient, and accurate way for a large number of people …
View article: Cognitive and Motor Norms for Huntington’s Disease
Cognitive and Motor Norms for Huntington’s Disease Open
Background The progression of Huntington’s disease (HD) for gene-expanded carriers is well-studied. Natural aging effects, however, are not often considered in the evaluation of HD progression. Objective To examine the effects of natural a…
View article: Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci
Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci Open
Background: Little is known about the functional mechanisms through which genetic loci associated with substance use traits ascertain their effect. This study aims to identify and functionally annotate loci associated with substance use tr…
View article: In the Archives - Paul Laurence Dunbar
In the Archives - Paul Laurence Dunbar Open
In this episode of In the Archives, Wright State University Archivist Dawne Dewey and University of Dayton Professor Emeritus Herbert W. Martin talk about the contributions Paul Laurence Dunbar made to Dayton and American Literature. Dewey…
View article: Genome‐wide association meta‐analysis of age at first cannabis use
Genome‐wide association meta‐analysis of age at first cannabis use Open
Background and aims Cannabis is one of the most commonly used substances among adolescents and young adults. Earlier age at cannabis initiation is linked to adverse life outcomes, including multi‐substance use and dependence. This study es…
View article: Issue Information ‐ TOC
Issue Information ‐ TOC Open
No abstract is available for this article.
View article: Genome‐wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences
Genome‐wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences Open
Background and aims The activity of CYP2A6, the major nicotine‐inactivating enzyme, is measurable in smokers using the nicotine metabolite ratio (NMR; 3′hydroxycotinine/cotinine). Due to its role in nicotine clearance, the NMR is associate…
View article: Does coffee consumption impact on heaviness of smoking?
Does coffee consumption impact on heaviness of smoking? Open
Background and Aims Coffee consumption and cigarette smoking are strongly associated, but whether this association is causal remains unclear. We sought to: (1) determine whether coffee consumption influences cigarette smoking causally, (2)…
View article: Computerised cognition-based interventions for maintaining cognitive function in cognitively healthy people in midlife
Computerised cognition-based interventions for maintaining cognitive function in cognitively healthy people in midlife Open
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the effects of computerised cognition‐based interventions on cognitive function in cognitively healthy people in midlife. We refer to Gates…
View article: Correction: G = E: What GWAS Can Tell Us about the Environment
Correction: G = E: What GWAS Can Tell Us about the Environment Open
[This corrects the article DOI: 10.1371/journal.pgen.1005765.].
View article: Genetic Relationship between Schizophrenia and Nicotine Dependence
Genetic Relationship between Schizophrenia and Nicotine Dependence Open
It is well known that most schizophrenia patients smoke cigarettes. There are different hypotheses postulating the underlying mechanisms of this comorbidity. We used summary statistics from large meta-analyses of plasma cotinine concentrat…
View article: Smoking and caffeine consumption: a genetic analysis of their association
Smoking and caffeine consumption: a genetic analysis of their association Open
Smoking and caffeine consumption show a strong positive correlation, but the mechanism underlying this association is unclear. Explanations include shared genetic/environmental factors or causal effects. This study employed three methods t…
View article: Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium
Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium Open
Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. …
View article: G = E: What GWAS Can Tell Us about the Environment
G = E: What GWAS Can Tell Us about the Environment Open
As our understanding of genetics has improved, genome-wide association studies (GWAS) have identified numerous variants associated with lifestyle behaviours and health outcomes. However, what is sometimes overlooked is the possibility that…
View article: Associations between smoking and caffeine consumption in two European cohorts
Associations between smoking and caffeine consumption in two European cohorts Open
There appears to be a positive association between smoking and caffeine consumption in the Netherlands and the United Kingdom.