Jennine Grootens
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View article: Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors
Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors Open
Mast cell accumulation is a hallmark of a number of diseases, including allergic asthma and systemic mastocytosis. Immunoglobulin E–mediated crosslinking of the FcεRI receptors causes mast cell activation and contributes to disease pathoge…
View article: Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors
Single-cell transcriptomics reveals the identity and regulators of human mast cell progenitors Open
Mast cell accumulation is a hallmark of a number of diseases including allergic asthma and systemic mastocytosis. IgE-mediated crosslinking of the FcεRI receptors causes mast cell activation and contributes to disease pathogenesis. The mas…
View article: CD203c distinguishes the erythroid and mast cell‐basophil differentiation trajectories among human FcεRI<sup>+</sup> bone marrow progenitors
CD203c distinguishes the erythroid and mast cell‐basophil differentiation trajectories among human FcεRI<sup>+</sup> bone marrow progenitors Open
IgE molecules that bind their specific antigen crosslink FcεRI receptors present on mast cells and basophils. Downstream signaling results in cell activation and subsequent release of diverse compounds that exhibit potential to trigger all…
View article: Mast cell development in health and systemic mastocytosis
Mast cell development in health and systemic mastocytosis Open
Hematopoietic progenitors in the bone marrow differentiate into several immune cells, including mast cells. Mast cell progenitors leave the bone marrow, circulate through the blood, and home to the periphery where they mature. This thesis …
View article: Single-cell analysis reveals the KIT D816V mutation in haematopoietic stem and progenitor cells in systemic mastocytosis
Single-cell analysis reveals the KIT D816V mutation in haematopoietic stem and progenitor cells in systemic mastocytosis Open
The KIT D816V mutation arises in early haematopoietic stem and progenitor cells and the mutation frequency is approaching 100% in mature mast cells, which express the aberrant marker CD45RA.
View article: Deciphering the differentiation trajectory from hematopoietic stem cells to mast cells
Deciphering the differentiation trajectory from hematopoietic stem cells to mast cells Open
Hematopoietic stem cells differentiate into all types of blood cells, including peripheral tissue-resident mast cells. The early mast cell differentiation takes place in the bone marrow, after which the progenitor cells enter the circulati…
View article: Single-cell analysis reveals the <i>KIT</i> D816V mutation in hematopoietic stem and progenitor cells in systemic mastocytosis: Supplementary data
Single-cell analysis reveals the <i>KIT</i> D816V mutation in hematopoietic stem and progenitor cells in systemic mastocytosis: Supplementary data Open
Background: Systemic mastocytosis (SM) is a hematological disease characterized by organ infiltration by neoplastic mast cells. Almost all SM patients have a mutation in the gene encoding the tyrosine kinase receptor KIT causing a D816V su…
View article: KIT signaling is dispensable for human mast cell progenitor development
KIT signaling is dispensable for human mast cell progenitor development Open
Key Points SCF and KIT signaling are dispensable for the survival, proliferation, and maturation of human mast cell progenitors.
View article: Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis
Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis Open
Systemic mastocytosis (SM) is a clonal bone marrow disorder, where therapeutical options are limited. Over 90% of the patients carry the D816V point mutation in the KIT receptor that renders this receptor constitutively active. We assessed…
View article: Identification of Biological and Pharmaceutical Mast Cell‐ and Basophil‐Related Targets
Identification of Biological and Pharmaceutical Mast Cell‐ and Basophil‐Related Targets Open
Mast cells and basophils have been studied mainly regarding their implication in IgE-mediated allergic disease. Yet, it has become clear that apart from the high-affinity IgE receptor (FcεRI), these cells can respond to many different infl…