Jenny A. Nguyen
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View article: The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells
The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells Open
Type I conventional dendritic cells (cDC1s) are essential for the generation of protective cytotoxic T lymphocyte (CTL) responses against many types of viruses and tumours. They do so by internalizing antigens from virally infected or tumo…
View article: Eructophagy: macrophages use autophagic machinery to burp out parts of their meal
Eructophagy: macrophages use autophagic machinery to burp out parts of their meal Open
The phagolysosome is an antimicrobial and degradative organelle that plays key roles in macrophage-mediated inflammatory and homeostatic functions. Whereas mature phagolysosomes are known to sequester and degrade their contents into basic …
View article: Better Together: Current Insights Into Phagosome-Lysosome Fusion
Better Together: Current Insights Into Phagosome-Lysosome Fusion Open
Following phagocytosis, the nascent phagosome undergoes maturation to become a phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill and digest engulfed microbes, cells, and debris. The fusion of pha…