Jenny I. Szu
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View article: Characterization of brain metabolism, volume, and vasculature of the 5xFAD mouse model of Alzheimer’s Disease across lifespan.
Characterization of brain metabolism, volume, and vasculature of the 5xFAD mouse model of Alzheimer’s Disease across lifespan. Open
Background The MODEL‐AD Consortium seeks to develop the next generation of Alzheimer’s Disease models based on human data. A popular model of familial AD is the 5xFAD mouse, characterized by early amyloid‐β deposition and cognitive decreme…
View article: Characterization of brain metabolism, volume, and vasculature of the 5xFAD mouse model of Alzheimer’s Disease across lifespan
Characterization of brain metabolism, volume, and vasculature of the 5xFAD mouse model of Alzheimer’s Disease across lifespan Open
Background The MODEL‐AD Consortium seeks to develop the next generation of Alzheimer’s Disease models based on human data. A popular model of familial AD is the 5xFAD mouse, characterized by early amyloid‐ß deposition and cognitive decreme…
View article: Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease
Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease Open
Introduction The 5xFAD mouse is a popular model of familial Alzheimer’s disease (AD) that is characterized by early beta-amyloid (Aβ) deposition and cognitive decrements. Despite numerous studies, the 5xFAD mouse has not been comprehensive…
View article: Biological functions of the Olig gene family in brain cancer and therapeutic targeting
Biological functions of the Olig gene family in brain cancer and therapeutic targeting Open
The Olig genes encode members of the basic helix–loop–helix (bHLH) family of transcription factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central nervous system (CNS) and regulate cellular specification an…
View article: Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease
Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease Open
The 5xFAD mouse model is a popular model of familial Alzheimer’s Disease (AD) that is characterized by early beta-amyloid (Aβ) deposition and cognitive decrements. Despite numerous studies, the 5xFAD mouse has not been comprehensively phen…
View article: Editorial: Mechanisms and consequences of Aquaporin-4 redistribution in neurological disease
Editorial: Mechanisms and consequences of Aquaporin-4 redistribution in neurological disease Open
EDITORIAL article Front. Cell. Neurosci., 01 February 2023Sec. Cellular Neuropathology Volume 17 - 2023 | https://doi.org/10.3389/fncel.2023.1143352
View article: Progressive Vascular Abnormalities in the Aging 3xTg-AD Mouse Model of Alzheimer’s Disease
Progressive Vascular Abnormalities in the Aging 3xTg-AD Mouse Model of Alzheimer’s Disease Open
Vascular dysfunction and structural abnormalities in Alzheimer’s disease (AD) are known to contribute to the progression of the pathology, and studies have tended to ignore the role of the vasculature in AD progression. We utilized the 3xT…
View article: Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy
Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy Open
Epilepsy is a chronic brain disorder characterized by unprovoked seizures. Mechanisms underlying seizure activity have been intensely investigated. Alterations in astrocytic channels and transporters have shown to be a critical player in s…
View article: Impact of the Olig Family on Neurodevelopmental Disorders
Impact of the Olig Family on Neurodevelopmental Disorders Open
The Olig genes encode members of the basic helix-loop-helix (bHLH) family of transcription factors. Olig1, Olig2, and Olig3 are expressed in both the developing and mature central nervous system (CNS) and strictly regulate cellular specifi…
View article: Identifying Potential Biomarkers of Posttraumatic Epilepsy
Identifying Potential Biomarkers of Posttraumatic Epilepsy Open
Posttraumatic epilepsy (PTE) is a long-term negative consequence of traumatic brain injury (TBI) in which recurrent spontaneous seizures occur after the initial head injury. PTE develops over an undefined period where circuitry reorganizat…
View article: GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii
GLT-1-Dependent Disruption of CNS Glutamate Homeostasis and Neuronal Function by the Protozoan Parasite Toxoplasma gondii Open
The immune privileged nature of the CNS can make it vulnerable to chronic and latent infections. Little is known about the effects of lifelong brain infections, and thus inflammation, on the neurological health of the host. Toxoplasma gond…
View article: The Role of Astrocytic Aquaporin-4 in Synaptic Plasticity and Learning and Memory
The Role of Astrocytic Aquaporin-4 in Synaptic Plasticity and Learning and Memory Open
Aquaporin-4 (AQP4) is the predominant water channel expressed by astrocytes in the central nervous system (CNS). AQP4 is widely expressed throughout the brain, especially at the blood-brain barrier where AQP4 is highly polarized to astrocy…