Explanipedia

POS0947 ANTI-NOR-90 ANTIBODIES IN AN INTERNATIONAL COHORT OF 2140 SYSTEMIC SCLEROSIS SUBJECTS: CLINICAL ASSOCIATIONS Open

Hui Shen, Marie Hudson, Susanna Proudman, Jenny Walker, W. Stevens , et al. · 2025

Prevalence and Outcomes of Gastrointestinal Manifestations in an Australian Scleroderma Cohort Open

Alannah Quinlivan, Dominique Hansen, W. Stevens, Laura Ross, Nava Ferdowsi , et al. · 2024

Objective The gastrointestinal tract (GIT) is the most commonly affected internal organ in systemic sclerosis (SSc). We sought to determine the prevalence and impact of GIT symptoms on survival and patient‐reported outcomes. Methods A tota…

Investigating the trajectory of functional disability in systemic sclerosis: group-based trajectory modelling of the Health Assessment Questionnaire-Disability Index Open

Jessica Fairley, Dylan Hansen, Murray Baron, Susanna Proudman, Joanne Sahhar , et al. · 2024

Two trajectories of functional disability in SSc were identified. Those with high-increasing functional disability had a distinct clinical phenotype and worse survival compared to those with low-stable functional disability. These data hig…

The impact of gastroesophageal reflux disease and its treatment on interstitial lung disease outcomes Open

Alannah Quinlivan, Dennis R. Neuen, Dominique Hansen, Wendy Stevens, Laura Ross , et al. · 2024

Prognostic and functional importance of both overt and subclinical left ventricular systolic dysfunction in systemic sclerosis Open

Jessica Fairley, Dylan Hansen, Susanna Proudman, Joanne Sahhar, Gene‐Siew Ngian , et al. · 2024

Both overt and subclinical SSc-associated LV dysfunction are associated with worse survival and impaired physical function. The frequency of abnormal LV-GLS in those with consistently normal LVEF suggests an under-appreciated burden of sub…

Inflammatory Arthritis in Systemic Sclerosis: Its Epidemiology, Associations, and Morbidity Open

Eric Schwender, Dylan Hansen, Wendy Stevens, Laura Ross, Susanna Proudman , et al. · 2024

Objective To describe the epidemiology, associations, and impact of inflammatory arthritis (IA) in systemic sclerosis (SSc). Methods Patients with SSc prospectively enrolled in the Australian Scleroderma Cohort Study were included. IA was …

Proximal weakness and creatine kinase elevation in systemic sclerosis: Clinical correlates, prognosis and functional implications Open

Jessica Fairley, Dylan Hansen, Jessica Day, Susanna Proudman, Joanne Sahhar , et al. · 2024

Clinical features of myopathy are highly prevalent in SSc, affecting almost half of our study cohort. Detection of PW and elevated CK alone, even without imaging or histopathological identification of SSc-myopathy, identified important cli…

OA13 The skin as a snapshot of systemic inflammation Open

Thomas Khoo, Athena Chin, Jenny Walker · 2023

Introduction This case focuses on a polymorphic rash of multidisciplinary interest in the setting of seemingly disparate multi-organ inflammatory phenomena. The case highlights the use and shortcomings of skin histopathology in diagnosing …

Impact of the <span>COVID</span>‐19 Pandemic on Health Care Access and Diagnosis of Pulmonary Arterial Hypertension Among Patients With Systemic Sclerosis Open

Alicia Callisto, Dylan Hansen, Jenny Walker, Gene Siew Ngian, Diane Apostolopoulos , et al. · 2023

Objective Regular clinical assessment for complications of systemic sclerosis (SSc) such as pulmonary arterial hypertension (PAH) is essential for early institution of therapy and improved outcomes. The objective of this study was to deter…

AB0054 BIOMARKERS OF BONE ACTIVITY IN RHEUMATOID ARTHRITIS SYNOVIAL TISSUE AND THEIR RELATIONSHIP WITH CLINICAL OUTCOME Open

Brian Le, Annabelle Small, Katie Lowe, Helen Weedon, Susanna Proudman , et al. · 2023

POS1269 INVESTIGATING THE TRAJECTORY OF FUNCTIONAL DISABILITY IN SYSTEMIC SCLEROSIS: GROUP BASED TRAJECTORY MODELLING OF THE HEALTH ASSESSMENT QUESTIONNAIRE DISABILITY INDEX Open

Jessica Fairley, Dominique Hansen, Murray Baron, S. Proudman, J. A. Sahhar , et al. · 2023

AB0902 LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IS RARE BUT PROGNOSTICALLY IMPORTANT IN SYSTEMIC SCLEROSIS Open

Jessica Fairley, Dominique Hansen, S. Proudman, J. A. Sahhar, Gene‐Siew Ngian , et al. · 2023

Abstracts Open

Iolanda Miceli, Rochelle Sherlock, Ianian Cheang, Akshay A. D’Cruz, Taylah J. Bennett , et al. · 2023

Aims: Aberrant immune cell activation characterises SLE, in which glucocorticoids (GCs) remain a cornerstone of treatment.However, the unacceptable side effects of GCs have created a pressing need for a similarly broad-acting, but safer, a…

Association Between Immunosuppressive Therapy and Incident Risk of Interstitial Lung Disease in Systemic Sclerosis Open

Sabrina Hoa, Sasha Bernatsky, Murray Baron, Susanna Proudman, Wendy Stevens , et al. · 2021

Clinical Features of Systemic Sclerosis–Mixed Connective Tissue Disease and Systemic Sclerosis Overlap Syndromes Open

Jessica Fairley, Dylan Hansen, Susanna Proudman, Joanne Sahhar, Gene‐Siew Ngian , et al. · 2020

Objective To describe the clinical characteristics and outcomes of systemic sclerosis–mixed connective tissue disease (SSc–MCTD) and SSc overlap syndrome. Methods We included patients from the Australian Scleroderma Cohort Study who met Am…

Significance of anti-neutrophil cytoplasmic antibodies in systemic sclerosis Open

Jayne Moxey, Molla Huq, Susanna Proudman, Joanne Sahhar, Gene-Siew Ngian , et al. · 2019

Surgical re-excision vs. observation for dysplastic naevi Open

Kim T. Vuong, Jenny Walker, Helen B. Powell, Naveen Thomas, Daniel E Jonas , et al. · 2018

Pathologists, doctors who study the causes and effects of diseases, look at samples of skin under the microscope. Unusual moles of the skin, called histologically dysplastic nevi (HDN), are checked for cancer. HDN are present in 2‐10% of t…

THU0025 Florid synovitis after pd1 antagonist therapy is characterised by a marked absence of pd1+ infiltrating t cells Open

William Murray‐Brown, Tom D Wilsdon, Helen Weedon, Susanna Proudman, Malcolm Smith , et al. · 2018

Single-specificity anti-Ku antibodies in an international cohort of 2140 systemic sclerosis subjects Open

S. Hoa, Marie Hudson, Yves Troyanov, S. Proudman, Jenny Walker , et al. · 2016

Autoantibodies directed against the Ku autoantigen are present in systemic sclerosis (SSc) and have been associated with myositis overlap and interstitial lung disease (ILD). However, there is a paucity of data on the clinical correlates o…

Jenny Walker YOU? Author Swipe