Jens Eilers
YOU?
Author Swipe
View article: Presynaptic <scp>ATP</scp> Decreases During Physiological‐Like Activity in Neurons Tuned for High‐Frequency Transmission
Presynaptic <span>ATP</span> Decreases During Physiological‐Like Activity in Neurons Tuned for High‐Frequency Transmission Open
Recent evidence indicates that the concentration of ATP remains stable during neuronal activity due to activity‐dependent ATP production. However, the mechanisms of activity‐dependent ATP production remain controversial. To stabilize the A…
View article: Unreliable homeostatic action potential broadening in cultured dissociated neurons
Unreliable homeostatic action potential broadening in cultured dissociated neurons Open
Summary Homeostatic plasticity preserves neuronal activity against perturbations. Recently, somatic action potential broadening was proposed as a key homeostatic adaptation to chronic inactivity in neocortical neurons. Since action potenti…
View article: Unreliable homeostatic action potential broadening in cultured dissociated neurons
Unreliable homeostatic action potential broadening in cultured dissociated neurons Open
Summary Homeostatic plasticity preserves neuronal activity against perturbations. Recently, somatic action potential broadening was proposed as a key homeostatic adaptation to chronic inactivity in neocortical neurons. Since action potenti…
View article: The intracellular Ca <sup>2+</sup> sensitivity of transmitter release in glutamatergic neocortical boutons
The intracellular Ca <sup>2+</sup> sensitivity of transmitter release in glutamatergic neocortical boutons Open
Synaptotagmin-1 (Syt1) and Syt2 are the main calcium (Ca 2+ ) sensors triggering synchronous release in the brain. In this work, we studied the mechanisms mediating Syt1-triggered release from neocortical synapses. We measured the Ca 2+ de…
View article: Unreliable homeostatic action potential broadening in cultured dissociated neurons
Unreliable homeostatic action potential broadening in cultured dissociated neurons Open
Summary Homeostatic plasticity preserves neuronal activity against perturbations. Recently, somatic action potential broadening was proposed as a key homeostatic adaptation to chronic inactivity in neocortical neurons. Since action potenti…
View article: Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia
Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia Open
Spreading depolarizations (SDs) have been identified in various brain pathologies. SDs increase the cerebral energy demand and, concomitantly, oxygen consumption, which indicates enhanced synthesis of adenosine triphosphate (ATP) by oxidat…
View article: Ultrastructural membrane dynamics of mouse and human cortical synapses
Ultrastructural membrane dynamics of mouse and human cortical synapses Open
Live human brain tissues provide unique opportunities for understanding synaptic transmission. Investigations have been limited to anatomy, electrophysiology, and protein localization, while crucial parameters such as synaptic vesicle dyna…
View article: Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia
Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia Open
Spreading depolarizations (SDs) have been identified in various brain pathologies. SDs increase the cerebral energy demand and, concomitantly, oxygen consumption, which indicates enhanced synthesis of adenosine triphosphate (ATP) by oxidat…
View article: KATP channel mutation disrupts hippocampal network activity and nocturnal gamma shifts
KATP channel mutation disrupts hippocampal network activity and nocturnal gamma shifts Open
ATP-sensitive potassium (KATP) channels couple cell metabolism to cellular electrical activity. Humans affected by severe activating mutations in KATP channels suffer from developmental delay, epilepsy and neonatal diabetes (DEND syndrome)…
View article: Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials
Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials Open
Understanding the function of the human brain requires determining basic properties of synaptic transmission in human neurons. One of the most fundamental parameters controlling neurotransmitter release is the presynaptic action potential,…
View article: The intracellular Ca<sup>2+</sup>sensitivity of transmitter release from neocortical boutons
The intracellular Ca<sup>2+</sup>sensitivity of transmitter release from neocortical boutons Open
Synaptotagmin 1 (Syt1) and Syt2 are the main Ca 2+ sensors triggering synchronous release in the brain. The Ca 2+ -sensitivity of Syt2-triggered release has been studied in detail. However, for Syt1, the dominating isoform in the neocortex…
View article: Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons
Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons Open
Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer 5 pyramidal neurons, LTP increases the initial synaptic strength but also short-term depression during h…
View article: K<sub>ATP</sub>channel mutation disrupts hippocampal network activity and nocturnal γ shifts
K<sub>ATP</sub>channel mutation disrupts hippocampal network activity and nocturnal γ shifts Open
ATP-sensitive potassium (K ATP ) channels enable ATP to control the membrane potential and insulin secretion. Humans affected by severe activating mutations in K ATP channels suffer from developmental d elay, e pilepsy and n eonatal d iabe…
View article: Ca<sub>v</sub>2.2 Channels Sustain Vesicle Recruitment at a Mature Glutamatergic Synapse
Ca<sub>v</sub>2.2 Channels Sustain Vesicle Recruitment at a Mature Glutamatergic Synapse Open
The composition of voltage-gated Ca 2+ channel (Ca v ) subtypes that gate action potential (AP)-evoked release changes during the development of mammalian CNS synapses. Ca v 2.2 and Ca v 2.3 lose their function in gating-evoked release dur…
View article: Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons
Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons Open
Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer 5 pyramidal neurons LTP increases the initial synaptic strength but also short-term depression during hi…
View article: Gray and white matter astrocytes differ in basal metabolism but respond similarly to neuronal activity
Gray and white matter astrocytes differ in basal metabolism but respond similarly to neuronal activity Open
Astrocytes are a heterogeneous population of glial cells in the brain, which adapt their properties to the requirements of the local environment. Two major groups of astrocytes are protoplasmic astrocytes residing in gray matter as well as…
View article: Calcium dependence of neurotransmitter release at a high fidelity synapse
Calcium dependence of neurotransmitter release at a high fidelity synapse Open
The Ca 2+ -dependence of the priming, fusion, and replenishment of synaptic vesicles are fundamental parameters controlling neurotransmitter release and synaptic plasticity. Despite intense efforts, these important steps in the synaptic ve…
View article: Author response: Calcium dependence of neurotransmitter release at a high fidelity synapse
Author response: Calcium dependence of neurotransmitter release at a high fidelity synapse Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The Ca2+-dependence of the priming, fusion…
View article: Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages
Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages Open
A chronic low-grade inflammation within adipose tissue (AT) seems to be the link between obesity and some of its associated diseases. One hallmark of this AT inflammation is the accumulation of AT macrophages (ATMs) around dead or dying ad…
View article: Calcium dependence of neurotransmitter release at a high fidelity synapse
Calcium dependence of neurotransmitter release at a high fidelity synapse Open
The Ca 2+ -dependence of the recruitment, priming, and fusion of synaptic vesicles are fundamental parameters controlling neurotransmitter release and synaptic plasticity. Despite intense efforts, these important steps in the synaptic vesi…
View article: Multinucleated giant cells in adipose tissue are specialized in adipocyte degradation
Multinucleated giant cells in adipose tissue are specialized in adipocyte degradation Open
Obesity is associated with a chronic low-grade inflammation in visceral adipose tissue (AT) characterized by an increasing number of adipose tissue macrophages (ATMs) and linked to type 2 diabetes. AT inflammation is histologically indicat…
View article: Multinucleated giant cells in adipose tissue are specialized in adipocyte degradation
Multinucleated giant cells in adipose tissue are specialized in adipocyte degradation Open
Obesity is associated with a chronic low-grade inflammation in visceral adipose tissue (AT) characterized by an increasing number of adipose tissue macrophages (ATMs) and linked to type 2 diabetes. AT inflammation is histologically indicat…
View article: Large, stable spikes exhibit differential broadening in excitatory and inhibitory neocortical boutons
Large, stable spikes exhibit differential broadening in excitatory and inhibitory neocortical boutons Open
SUMMARY Presynaptic action potential spikes control neurotransmitter release and thus interneuronal communication. However, the properties and the dynamics of presynaptic spikes in the neocortex remain enigmatic because boutons in the neoc…
View article: Undisturbed climbing fiber pruning in the cerebellar cortex of <scp>CX<sub>3</sub>CR1</scp>‐deficient mice
Undisturbed climbing fiber pruning in the cerebellar cortex of <span>CX<sub>3</sub>CR1</span>‐deficient mice Open
Pruning, the elimination of excess synapses is a phenomenon of fundamental importance for correct wiring of the central nervous system. The establishment of the cerebellar climbing fiber (CF)‐to‐Purkinje cell (PC) synapse provides a suitab…