Jens Hukelmann
YOU?
Author Swipe
View article: Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development
Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development Open
Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet the molecular components required for their maintenance and effector functions remain incompletely defined. Inactivation of VPS34 in Treg cells led…
View article: First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors
First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors Open
Rationale of the trial Although the use of engineered T cells in cancer immunotherapy has greatly advanced the treatment of hematological malignancies, reaching meaningful clinical responses in the treatment of solid tumors is still challe…
View article: Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development
Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development Open
Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet the molecular components required for their maintenance and effector functions remain incompletely defined. Inactivation of VPS34 in Treg cells led…
View article: 713 The PRAME opportunity – high peptide copy numbers, homogenous expression and high prevalence to address a broad patient population across different solid cancers with TCR-based therapeutics
713 The PRAME opportunity – high peptide copy numbers, homogenous expression and high prevalence to address a broad patient population across different solid cancers with TCR-based therapeutics Open
Background Several peptide-HLA targets for T cell receptor (TCR)-based immunotherapies are currently being evaluated in the field, however, many are limited by their overall low prevalence, low copy numbers or relevant expression in health…
View article: Super‐killer CTLs are generated by single gene deletion of Bach2
Super‐killer CTLs are generated by single gene deletion of Bach2 Open
Bach2 codes for a transcriptional regulator exerting major influences on T cell‐mediated immune regulation. Effector CTLs derived from in vitro activation of murine CD8 + T cells showed increased proliferative and cytolytic capacity in the…
View article: The Immunological Proteome Resource
The Immunological Proteome Resource Open
The Immunological Proteome Resource (ImmPRes ; http://immpres.co.uk/ ) is an open access public resource integrating proteomic data generated by large-scale mass-spectrometry analysis of murine hematopoietic populations. The initial focus …
View article: Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response Open
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protei…
View article: Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes
Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes Open
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and nat…
View article: Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response
Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response Open
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved networks of cytoprotective proteins controlled by nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator the Kelch-like ECH assoc…
View article: Author response: Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes
Author response: Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Tissue-resident intestinal intraepithelial…
View article: Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism
Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism Open
Limiting dysfunctional neutrophilic inflammation while preserving effective immunity requires a better understanding of the processes that dictate neutrophil function in the tissues. Quantitative mass-spectrometry identified how inflammato…
View article: Tissue environment, not ontogeny, defines intestinal intraepithelial T lymphocytes
Tissue environment, not ontogeny, defines intestinal intraepithelial T lymphocytes Open
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and nat…
View article: Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation
Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation Open
The integration of multiple signalling pathways that co-ordinate T cell metabolism and transcriptional reprogramming is required to drive T cell differentiation and proliferation. One key T cell signalling module is mediated by extracellul…
View article: Erosion of human X chromosome inactivation causes major remodelling of the iPSC proteome
Erosion of human X chromosome inactivation causes major remodelling of the iPSC proteome Open
Summary X chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals whereby genes from one X chromosome are repressed. Analysis of human induced pluripotent stem cell (iPSC) lines using proteomics, RNAseq and polys…
View article: Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland
Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland Open
Aims: Left ventricular hypertrophy (LVH) is independently associated with adverse cardiovascular outcome. The pathophysiology of LVH development remains unclear although observational studies have reported its association with blood pressu…
View article: Multibatch TMT Reveals False Positives, Batch Effects and Missing Values
Multibatch TMT Reveals False Positives, Batch Effects and Missing Values Open
Multiplexing strategies for large-scale proteomic analyses have become increasingly prevalent, tandem mass tags (TMT) in particular. Here we used a large iPSC proteomic experiment with twenty-four 10-plex TMT batches to evaluate the effect…
View article: Antigen receptor control of methionine metabolism in T cells
Antigen receptor control of methionine metabolism in T cells Open
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study uses high resolution…
View article: Author response: Antigen receptor control of methionine metabolism in T cells
Author response: Antigen receptor control of methionine metabolism in T cells Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Immune activated T lymphocyte…
View article: Antigen receptor control of methionine metabolism in T cells
Antigen receptor control of methionine metabolism in T cells Open
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study uses high resolution…
View article: Optimising multi-batch TMT analysis to mitigate inflation of missing values, false positives and diminished inter batch accuracy
Optimising multi-batch TMT analysis to mitigate inflation of missing values, false positives and diminished inter batch accuracy Open
Multiplexing strategies for large-scale proteomic analyses have become increasingly prevalent, TMT in particular. Here we used a large iPSC proteomic experiment with twenty-four 10-plex TMT batches to evaluate the effect of integrating mul…
View article: The iPSC proteomic compendium
The iPSC proteomic compendium Open
Induced pluripotent stem cell (iPSC) technology holds great potential for therapeutic and research purposes. The Human Induced Pluripotent Stem Cell Initiative (HipSci) was established to generate a panel of high-quality iPSCs, from health…