Jens Lerchl
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View article: A rearranged <i>Amaranthus palmeri</i> extrachromosomal circular DNA confers resistance to glyphosate and glufosinate
A rearranged <i>Amaranthus palmeri</i> extrachromosomal circular DNA confers resistance to glyphosate and glufosinate Open
Some herbicide-resistant weeds become resistant by generating additional copies of specific loci. For example, amplification of the locus encoding chloroplastic glutamine synthetase (GS2) produces herbicide resistance in the glufosinate-re…
View article: Distribution of glufosinate resistance and glutamine synthetase copy number variation among Palmer amaranth (<i>Amaranthus palmeri</i>) accessions in northeast Arkansas
Distribution of glufosinate resistance and glutamine synthetase copy number variation among Palmer amaranth (<i>Amaranthus palmeri</i>) accessions in northeast Arkansas Open
The presence of glufosinate-resistant Palmer amaranth ( Amaranthus palmeri S. Watson) is of concern for Arkansas farmers. The objective of this study was to understand the distribution of glufosinate resistance among A. palmeri accessions …
View article: Extrachromosomal DNA-mediated glutamine synthetase 2 (<i>GS2</i>) amplification enables glufosinate resistance in<i>Amaranthus palmeri</i>
Extrachromosomal DNA-mediated glutamine synthetase 2 (<i>GS2</i>) amplification enables glufosinate resistance in<i>Amaranthus palmeri</i> Open
Background Palmer amaranth achieves resistance to glufosinate by overproducing the chloroplastic glutamine synthetase (GS2) protein, a result of the amplification and overexpression of its nuclear coding gene. This study examined how ampli…
View article: A Novel Genomic Rearrangement in the<i>Amaranthus palmeri</i>Extrachromosomal Circular DNA Provides Dual Herbicide Resistance to Glyphosate and Glufosinate
A Novel Genomic Rearrangement in the<i>Amaranthus palmeri</i>Extrachromosomal Circular DNA Provides Dual Herbicide Resistance to Glyphosate and Glufosinate Open
Amplification of chloroplastic glutamine synthetase ( GS2 ) has been characterized as one of the resistance mechanisms in glufosinate-resistant Amaranthus palmeri accession (MSR2). Previously, the overamplification of the glyphosate-resist…
View article: 3D structure of acetolactate synthase explains why the Asp-376-Glu point mutation does not give the same resistance level to different imidazolinone herbicides
3D structure of acetolactate synthase explains why the Asp-376-Glu point mutation does not give the same resistance level to different imidazolinone herbicides Open
Resistance to ALS-inhibiting herbicides has dramatically increased worldwide due to the persisting evolution of target site mutations that reduce the affinity between the herbicide and the target. We evaluated the effect of the well-known …
View article: The International Weed Genomics Consortium: Community Resources for Weed Genomics Research
The International Weed Genomics Consortium: Community Resources for Weed Genomics Research Open
The International Weed Genomics Consortium is a collaborative group of researchers focused on developing genomic resources for the study of weedy plants. Weeds are attractive systems for basic and applied research due to their impacts on a…
View article: Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass
Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass Open
Repeated herbicide applications in agricultural fields exert strong selection on weeds such as blackgrass ( Alopecurus myosuroides ), which is a major threat for temperate climate cereal crops. This inadvertent selection pressure provides …
View article: Discovery, mode of action, resistance mechanisms, and plan of action for sustainable use of Group 14 herbicides
Discovery, mode of action, resistance mechanisms, and plan of action for sustainable use of Group 14 herbicides Open
Protoporphyrinogen oxidase (PPO)-inhibiting herbicides remain an important and useful chemistry 60 yr after their first introduction. In this review, based on topics introduced at the Weed Science Society of America 2021 symposium titled “…
View article: Assessment of Efficacy and Mechanism of Resistance to Soil-Applied PPO Inhibitors in Amaranthus palmeri
Assessment of Efficacy and Mechanism of Resistance to Soil-Applied PPO Inhibitors in Amaranthus palmeri Open
Resistance to protoporphyrinogen oxidase (PPO) inhibitors in Palmer amaranth is a major concern, given the high selection pressure and increasing number of populations with reduced sensitivity to PPO herbicides in the US. We evaluated the …
View article: Additional Files for "Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass"
Additional Files for "Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass" Open
This dataset contains additional supporting files referenced by the following publication: • Kersten S, Chang J, Huber CD, Voichek Y, Lanz C, Hagmaier T, Lang P, Lutz U, Hirschberg I, Lerchl J, Porri A, Van de Peer Y, Schmid K, Weigel D, R…
View article: Additional Files for "Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass"
Additional Files for "Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass" Open
This dataset contains additional supporting files referenced by the following publication: • Kersten S, Chang J, Huber CD, Voichek Y, Lanz C, Hagmaier T, Lang P, Lutz U, Hirschberg I, Lerchl J, Porri A, Van de Peer Y, Schmid K, Weigel D, R…
View article: Inhibition profile of trifludimoxazin towards <scp>PPO2</scp> target site mutations
Inhibition profile of trifludimoxazin towards <span>PPO2</span> target site mutations Open
BACKGROUND Target site resistance to herbicides that inhibit protoporphyrinogen IX oxidase (PPO; EC 1.3.3.4) has been described mainly in broadleaf weeds based on mutations in the gene designated protoporphyrinogen oxidase 2 (PPO2) and in …
View article: Survey of <scp>ACCase</scp> and <scp>ALS</scp> resistance in winter annual grasses identifies target‐site and nontarget‐site imazamox resistance in <scp><i>Secale cereale</i></scp>
Survey of <span>ACCase</span> and <span>ALS</span> resistance in winter annual grasses identifies target‐site and nontarget‐site imazamox resistance in <span><i>Secale cereale</i></span> Open
Background Early detection of herbicide resistance in weeds is crucial for successful implementation of integrated weed management. We conducted a herbicide resistance survey of the winter annual grasses feral rye ( Secale cereale ), downy…
View article: Field-Evolved ΔG210-ppo2 from Palmer Amaranth Confers Pre-emergence Tolerance to PPO-Inhibitors in Rice and Arabidopsis
Field-Evolved ΔG210-ppo2 from Palmer Amaranth Confers Pre-emergence Tolerance to PPO-Inhibitors in Rice and Arabidopsis Open
Resistance to protoporphyrinogen IX oxidase (PPO)-inhibitors in Amaranthus palmeri and Amaranthus tuberculatus is mainly contributed by mutations in the PPO enzyme, which renders herbicide molecules ineffective. The deletion of glycine210 …
View article: Can double <scp>PPO</scp> mutations exist in the same allele and are such mutants functional?
Can double <span>PPO</span> mutations exist in the same allele and are such mutants functional? Open
BACKGROUND Resistance to protoporphyrinogen oxidase (PPO)‐inhibiting herbicides is endowed primarily by target‐site mutations at the PPX2 gene that compromise binding of the herbicide to the catalytic domain. In Amaranthus spp. PPX2 , the …
View article: Can double PPO mutations exist in a same allele and are such mutants functional?
Can double PPO mutations exist in a same allele and are such mutants functional? Open
Background Resistance to PPO-inhibiting herbicides is primarily endowed by target site mutations at the PPO2 gene that compromise binding of the herbicide to the catalytic domain. In Amaranthus ssp. PPO2 , the most prevalent target mutatio…
View article: Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass
Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass Open
Repeated herbicide applications exert enormous selection on blackgrass ( Alopecurus myosuroides ), a major weed in cereal crops of the temperate climate zone including Europe. This inadvertent large-scale experiment gives us the opportunit…
View article: Draft Genomes of Amaranthus tuberculatus, Amaranthus hybridus, and Amaranthus palmeri
Draft Genomes of Amaranthus tuberculatus, Amaranthus hybridus, and Amaranthus palmeri Open
Amaranthus tuberculatus, Amaranthus hybridus, and Amaranthus palmeri are agronomically important weed species. Here, we present the most contiguous draft assemblies of these three species to date. We utilized a combination of Pacific Biosc…
View article: A new herbicidal site of action: Cinmethylin binds to acyl-ACP thioesterase and inhibits plant fatty acid biosynthesis
A new herbicidal site of action: Cinmethylin binds to acyl-ACP thioesterase and inhibits plant fatty acid biosynthesis Open
The prevalent occurrence of herbicide resistant weeds increases the necessity for new site of action herbicides for effective control as well as to relax selection pressure on the known sites of action. As a consequence, interest increased…