Jens Minnerup
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View article: How We Can Optimize Dysmenorrhea Treatment: Real-World Results from a Cross-Sectional, Multi-Center Study
How We Can Optimize Dysmenorrhea Treatment: Real-World Results from a Cross-Sectional, Multi-Center Study Open
Dysmenorrhea is a common and disabling condition in women. We investigate the prevalence of endocrine dysmenorrhea treatment (EDT) and the use of pain medication in dysmenorrhea patients without surgically treated endometriosis (no-STE). P…
View article: Sex Differences in Prognostic Markers: Exploring Outcome Variability After Mechanical Thrombectomy in Large Vessel Occlusion Stroke
Sex Differences in Prognostic Markers: Exploring Outcome Variability After Mechanical Thrombectomy in Large Vessel Occlusion Stroke Open
Background: Sex-related disparities in long-term outcomes after large vessel occlusion (LVO) following mechanical thrombectomy (MT) have been repeatedly shown. Notably, a lower likelihood of achieving functional independence 90 days post-s…
View article: Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling
Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling Open
Physical exercise is an effective therapy for improving stroke recovery. However, the exact underlying molecular mechanisms of exercise-enhanced neuronal repair remain unclear. As exercise affects the immune system in healthy individuals, …
View article: The nuclear receptor NR4A1 serves as a neutrophil-intrinsic regulator mitigating stroke severity
The nuclear receptor NR4A1 serves as a neutrophil-intrinsic regulator mitigating stroke severity Open
Ischemic stroke is accompanied by recruitment and activation of immune cells which play an important role in the progression of the brain damage. The nuclear receptor NR4A1 emerged as a key regulator within the inflammatory response of sev…
View article: Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies
Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies Open
Diseases affecting multiple peripheral nerves, termed polyneuropathies (PNPs), are common, mechanistically heterogeneous, and their causes are challenging to identify. Here, we integrated single-nucleus transcriptomics of peripheral nerves…
View article: Interdisciplinary neurovascular networks in Germany: update 2025
Interdisciplinary neurovascular networks in Germany: update 2025 Open
Background Neurovascular networks (NVNs) in Germany are supra-regional care structures for patients with neurovascular diseases. Each NVN consists of a tertiary care center serving as the coordinating center—in some cases, two or three coo…
View article: Navigating the distal vasculature: Challenges and lessons learned from failed Thrombectomy trials
Navigating the distal vasculature: Challenges and lessons learned from failed Thrombectomy trials Open
Background While endovascular thrombectomy (EVT) is firmly established for large vessel occlusion stroke, recent enthusiasm for extending EVT to distal medium vessel occlusions (DMVOs) has been tempered by the neutral results of three majo…
View article: Neutrophil progenitor mobilization is a distinct feature of STEMI and predicts survival
Neutrophil progenitor mobilization is a distinct feature of STEMI and predicts survival Open
Inflammatory cardiovascular diseases are the leading cause of death worldwide. Neutrophils, key drivers during inflammation, have consistently been associated with adverse outcomes and mortality in cardiovascular pathologies. Given the uni…
View article: Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the <scp>Central Nervous System</scp> —A Multicenter Cohort Study in 163 Patients
Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the <span>Central Nervous System</span> —A Multicenter Cohort Study in 163 Patients Open
Objective The aim was to determine patient, disease, and treatment characteristics associated with outcome in patients with primary angiitis of the central nervous system (PACNS) in a large multicenter German cohort. Methods In a retrospec…
View article: Prävalenz des „Spitzfußes“ bei stationär behandelten Patienten eines Universitätsklinikums
Prävalenz des „Spitzfußes“ bei stationär behandelten Patienten eines Universitätsklinikums Open
View article: Neutrophil progenitor mobilization is a distinct feature of STEMI and predicts survival
Neutrophil progenitor mobilization is a distinct feature of STEMI and predicts survival Open
Inflammatory cardiovascular diseases are the leading cause of death worldwide. Neutrophils, key drivers during inflammation, have consistently been associated with adverse outcomes and mortality in cardiovascular pathologies. Given the uni…
View article: Ghrelin promotes neurologic recovery and neurogenesis in the chronic phase after experimental stroke
Ghrelin promotes neurologic recovery and neurogenesis in the chronic phase after experimental stroke Open
View article: Editorial: Novel approaches in diagnosis and management of ischemic edema in large vessel occlusion stroke, volume II
Editorial: Novel approaches in diagnosis and management of ischemic edema in large vessel occlusion stroke, volume II Open
View article: Association of oral anticoagulants with risk of brain haemorrhage expansion compared to no-anticoagulation
Association of oral anticoagulants with risk of brain haemorrhage expansion compared to no-anticoagulation Open
Background The impact of direct oral anticoagulants (DOAC) on haematoma size after intracerebral haemorrhage (ICH) compared to no-anticoagulation is controversial and prospective data are lacking. Methods The investigator-initiated, multic…
View article: Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels
Endovascular Treatment for Stroke Due to Occlusion of Medium or Distal Vessels Open
In persons with stroke with occlusion of medium or distal vessels, EVT did not result in a lower level of disability or a lower incidence of death than best medical treatment alone. (Funded by the Swiss National Science Foundation and othe…
View article: Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial
Efficacy and safety of nerinetide in acute ischaemic stroke in patients undergoing endovascular thrombectomy without previous thrombolysis (ESCAPE-NEXT): a multicentre, double-blind, randomised controlled trial Open
View article: A dietary intervention with conjugated linoleic acid enhances microstructural white matter reorganization in experimental stroke
A dietary intervention with conjugated linoleic acid enhances microstructural white matter reorganization in experimental stroke Open
Background A dietary supplementation with conjugated linoleic acid (CLA) was shown to attenuate inflammation and increase the proportions of circulating regulatory T cells (T regs ) and M2-type macrophages in disease models such as autoimm…
View article: Entzündliche Ursachen von Schlaganfällen – Diagnostik und Therapie
Entzündliche Ursachen von Schlaganfällen – Diagnostik und Therapie Open
View article: Anti‐<scp>LINGO</scp>‐1 treatment restores myelination of corticospinal tract neurons and improves functional recovery after stroke
Anti‐<span>LINGO</span>‐1 treatment restores myelination of corticospinal tract neurons and improves functional recovery after stroke Open
Demyelination of corticospinal tract neurons contributes to long‐term disability after cortical stroke. Nonetheless, poststroke myelin loss has not been addressed as a therapeutic target, so far. We hypothesized that an antibody‐mediated i…
View article: The dilemma of neuroprotection trials in times of successful endovascular recanalization
The dilemma of neuroprotection trials in times of successful endovascular recanalization Open
Background The “translational roadblock” between successful animal stroke studies and neutral clinical trials is usually attributed to conceptual weaknesses. However, we hypothesized that rodent studies cannot inform the human disease due …
View article: Inhibition of leukocyte migration after ischemic stroke by VE‐cadherin mutation in a mouse model leads to reduced infarct volumes and improved motor skills
Inhibition of leukocyte migration after ischemic stroke by VE‐cadherin mutation in a mouse model leads to reduced infarct volumes and improved motor skills Open
Aims To distinguish between the genuine cellular impact of the ischemic cascade by leukocytes and unspecific effects of edema and humoral components, two knock‐in mouse lines were utilized. Mouse lines Y731F and Y685F possess point mutatio…
View article: Computed tomography hypoperfusion-hypodensity mismatch vs. automated perfusion mismatch to identify stroke patients eligible for thrombolysis
Computed tomography hypoperfusion-hypodensity mismatch vs. automated perfusion mismatch to identify stroke patients eligible for thrombolysis Open
Background and purpose Automated perfusion imaging can detect stroke patients with unknown time of symptom onset who are eligible for thrombolysis. However, the availability of this technique is limited. We, therefore, established the nove…
View article: Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice
Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice Open
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease causing axonal degeneration and demyelination. Exercise in mice with active monophasic experimental autoimmune encephalomyelitis (EAE) attenuates disease severity associa…
View article: Evaluation of effectiveness and safety of the multizone NeVaTM stent retriever for mechanical thrombectomy in ischemic stroke
Evaluation of effectiveness and safety of the multizone NeVaTM stent retriever for mechanical thrombectomy in ischemic stroke Open
View article: Vasculitis and Ischemic Stroke in Lyme Neuroborreliosis—Interventional Management Approach and Literature Review
Vasculitis and Ischemic Stroke in Lyme Neuroborreliosis—Interventional Management Approach and Literature Review Open
Objective: In rare cases, Lyme neuroborreliosis (LNB) can induce cerebral vasculitis leading to severe stenosis of the cerebral vasculature and consecutive ischemia. Therapy is based on anti-biotic treatment of the tick-borne disease, wher…
View article: Issue Information
Issue Information Open
Wiley is a founding member of the UN-backed HINARI, AGORA, and OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries.
View article: EXERTION: a pilot trial on the effect of aerobic, smartwatch-controlled exercise on stroke recovery: effects on motor function, structural repair, cognition, mental well-being, and the immune system
EXERTION: a pilot trial on the effect of aerobic, smartwatch-controlled exercise on stroke recovery: effects on motor function, structural repair, cognition, mental well-being, and the immune system Open
View article: Phenobarbital in super‐refractory status epilepticus (<scp>PIRATE</scp>): A retrospective, multicenter analysis
Phenobarbital in super‐refractory status epilepticus (<span>PIRATE</span>): A retrospective, multicenter analysis Open
Objective Super‐refractory status epilepticus (SRSE) is an enduring or recurring SE after 24 h or more of general anesthesia. This study aimed to evaluate the efficacy and safety of phenobarbital (PB) for the treatment of SRSE. Methods Thi…
View article: Association of age with 1-year outcome in patients with acute ischaemic stroke treated with thrombectomy: real-world analysis in 18 506 patients
Association of age with 1-year outcome in patients with acute ischaemic stroke treated with thrombectomy: real-world analysis in 18 506 patients Open
Background To evaluate the association of age with long-term outcome after thrombectomy. Methods In a retrospective cohort study based on routine healthcare data from Germany between 2010 and 2018, we included 18 506 patients with acute is…
View article: A preclinical randomized controlled multi-centre trial of anti-interleukin-17A treatment for acute ischaemic stroke
A preclinical randomized controlled multi-centre trial of anti-interleukin-17A treatment for acute ischaemic stroke Open
Multiple consensus statements have called for preclinical randomized controlled trials to improve translation in stroke research. We investigated the efficacy of an interleukin-17A neutralizing antibody in a multi-centre preclinical random…