Jens Moons
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View article: The Dawn of Metal-Oxo Clusters as Artificial Proteases: From Discovery to the Present and Beyond
The Dawn of Metal-Oxo Clusters as Artificial Proteases: From Discovery to the Present and Beyond Open
The selective cleavage of peptide bonds in proteins is of paramount importance in many areas of the biological and medical sciences, playing a key role in protein structure/function/folding analysis, protein engineering, and targeted prote…
View article: Expanding the reactivity of inorganic clusters towards proteins: the interplay between the redox and hydrolytic activity of Ce(<scp>iv</scp>)-substituted polyoxometalates as artificial proteases
Expanding the reactivity of inorganic clusters towards proteins: the interplay between the redox and hydrolytic activity of Ce(<span>iv</span>)-substituted polyoxometalates as artificial proteases Open
The redox chemistry of CeIV-polyoxometalates towards proteins is linked to the redox-active residues on protein surface. It can be tuned by adjusting reaction parameters, directly impacting its efficiency and selectivity as an artificial p…
View article: Heterogeneous nanozymatic activity of Hf oxo-clusters embedded in a metal–organic framework towards peptide bond hydrolysis
Heterogeneous nanozymatic activity of Hf oxo-clusters embedded in a metal–organic framework towards peptide bond hydrolysis Open
A Hf-based NU-1000 metal organic framework as a hydrolytic nanozyme for peptide bonds in dipeptides and hen egg white lysozyme protein showed greater stability and better recyclability than previous Zr-/Hf-based nanozymes.
View article: Selective Hydrolysis of Terminal Glycosidic Bond in α‐1‐Acid Glycoprotein Promoted by Keggin and Wells–Dawson Type Heteropolyacids
Selective Hydrolysis of Terminal Glycosidic Bond in α‐1‐Acid Glycoprotein Promoted by Keggin and Wells–Dawson Type Heteropolyacids Open
The reactivity of a range of Keggin and Wells–Dawson type heteropolyacids (HPAs): H 3 PW 12 O 40 H 4 SiW 12 O 40 , H 3 PMo 12 O 40 , K 6 P 2 W 18 O 62 , and NaH 2 W 12 O 4 , towards the heavily glycosylated α‐1‐acid glycoprotein (AGP) is r…
View article: Discrete Hf<sub>18</sub> Metal‐oxo Cluster as a Heterogeneous Nanozyme for Site‐Specific Proteolysis
Discrete Hf<sub>18</sub> Metal‐oxo Cluster as a Heterogeneous Nanozyme for Site‐Specific Proteolysis Open
The selective hydrolysis of proteins by non‐enzymatic catalysis is difficult to achieve, yet it is crucial for applications in biotechnology and proteomics. Herein, we report that discrete hafnium metal‐oxo cluster [Hf 18 O 10 (OH) 26 (SO …
View article: Interplay between structural parameters and reactivity of Zr<sub>6</sub>-based MOFs as artificial proteases
Interplay between structural parameters and reactivity of Zr<sub>6</sub>-based MOFs as artificial proteases Open
Peptide bond hydrolysis catalyzed by NU-1000 MOF revealed key structural features that influence the catalytic performance of Zr6based MOFs.
View article: Modeling of Nanomolecular and Reticular Architectures with 6-fold Grooved, Programmable Interlocking Disks
Modeling of Nanomolecular and Reticular Architectures with 6-fold Grooved, Programmable Interlocking Disks Open
sponsorship: A.K. thanks the Research Foundation Flanders for a postdoctoral grant (166497/12Y9218N LV 5457) and KU Leuven for research and technical support. Dr. Meijie Li is thanked for arranging the purchase of the ILD toys. (Research F…