Jens van de Wouw
YOU?
Author Swipe
View article: Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models
Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models Open
The coronary microvasculature is principally responsible for matching coronary blood flow to myocardial demand of oxygen and nutrients. Short‐term control of coronary blood flow is achieved via alterations in coronary microvascular tone, w…
View article: Increased oxidative stress alters coronary microvascular tone in exercising swine with multiple comorbidities
Increased oxidative stress alters coronary microvascular tone in exercising swine with multiple comorbidities Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Dutch Cardiovascular Alliance Background/Objectives We have previously shown, in female swine that the combination of three c…
View article: Mapping individual cardiac cell types and their contribution in the development of heart failure in a multiple comorbidity porcine model
Mapping individual cardiac cell types and their contribution in the development of heart failure in a multiple comorbidity porcine model Open
Background Heart failure with preserved ejection fraction (HFpEF) is characterized by impaired left ventricular (LV) relaxation and filling due to increased myocardial stiffness and hypertrophy. The development of HFpEF is associated with …
View article: Reactive oxygen species mitigate perturbations in coronary microvascular tone in exercising swine with multiple risk factors
Reactive oxygen species mitigate perturbations in coronary microvascular tone in exercising swine with multiple risk factors Open
Background Multiple cardiovascular risk factors, such as diabetes mellitus (DM), chronic kidney disease (CKD) and dyslipidemia are known to induce inflammation and microvascular dysfunction contributing to impaired myocardial perfusion. We…
View article: Albumin is an interface between blood plasma and cell membrane, and not just a sponge
Albumin is an interface between blood plasma and cell membrane, and not just a sponge Open
Albumin is the most abundant protein in blood plasma and acts as a carrier for many circulating molecules. Hypoalbuminaemia, mostly caused by either renal or liver disease or malnutrition, can perturb vascular homeostasis and is involved i…
View article: Distinctive Alterations in Microvascular Function Due to Multiple Common Morbidities
Distinctive Alterations in Microvascular Function Due to Multiple Common Morbidities Open
In this thesis, we investigated the role of multiple common cardiovascular risk factors on the development of microvascular dysfunction and left ventricular diastolic dysfunction
View article: Endothelial Dysfunction, Atherosclerosis, and Increase of von Willebrand Factor and Factor VIII: A Randomized Controlled Trial in Swine
Endothelial Dysfunction, Atherosclerosis, and Increase of von Willebrand Factor and Factor VIII: A Randomized Controlled Trial in Swine Open
It is well known that high von Willebrand factor (VWF) and factor VIII (FVIII) levels are associated with an increased risk of cardiovascular disease. It is still debated whether VWF and FVIII are biomarkers of endothelial dysfunction and …
View article: Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction
Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction Open
Heart failure with a preserved ejection fraction (HFpEF) is associated with multiple comorbidities, such as old age, hypertension, type 2 diabetes and obesity and is more prevalent in females. Although the male obese ZSF1 rat has been prop…
View article: Experimental animal models of coronary microvascular dysfunction
Experimental animal models of coronary microvascular dysfunction Open
Coronary microvascular dysfunction (CMD) is commonly present in patients with metabolic derangements and is increasingly recognized as an important contributor to myocardial ischaemia, both in the presence and absence of epicardial coronar…
View article: Chronic Kidney Disease as a Risk Factor for Heart Failure With Preserved Ejection Fraction: A Focus on Microcirculatory Factors and Therapeutic Targets
Chronic Kidney Disease as a Risk Factor for Heart Failure With Preserved Ejection Fraction: A Focus on Microcirculatory Factors and Therapeutic Targets Open
Heart failure (HF) and chronic kidney disease (CKD) co-exist, and it is estimated that about 50% of HF patients suffer from CKD. Although studies have been performed on the association between CKD and HF with reduced ejection fraction (HFr…
View article: Limited synergy of obesity and hypertension, prevalent risk factors in onset and progression of heart failure with preserved ejection fraction
Limited synergy of obesity and hypertension, prevalent risk factors in onset and progression of heart failure with preserved ejection fraction Open
Obesity and hypertension are prevalent comorbidities in heart failure with preserved ejection fraction. To clarify if and how interaction between these comorbidities contributes to development of diastolic dysfunction, lean and obese ZSF1 …
View article: P497Altered myocardial function and perfusion in a swine model of diastolic dysfunction with multiple co-morbidities
P497Altered myocardial function and perfusion in a swine model of diastolic dysfunction with multiple co-morbidities Open
After an Acute Myocardial Infarction (AMI), Ischemia-Reperfusion (I/R) injury is responsible for a critical decrease in the number of viable cardiomyocytes (hCMs).Human myocardium harbors a population of endogenous cardiac stem/progenitor …
View article: Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening
Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening Open
The combination of three common comorbidities leads to systemic inflammation, myocardial oxidative stress, and coronary microvascular dysfunction, which associate with myocardial stiffening and LV diastolic dysfunction with preserved eject…
View article: P6485Alterations in myocardial oxygen balance in exercising swine with multiple comorbidities
P6485Alterations in myocardial oxygen balance in exercising swine with multiple comorbidities Open
CAD and comorbidities 1405CKD patients compared to matched controls, and the effect of apabetalone treatment on those pathways.Results: Apabetalone PK parameters were similar in controls and CKD patients.At baseline, plasma proteomics show…
View article: The microcirculation: a key player in obesity-associated cardiovascular disease
The microcirculation: a key player in obesity-associated cardiovascular disease Open
It is increasingly recognized that obesity is a risk factor for microvascular disease, involving both structural and functional changes in the microvasculature. This review aims to describe how obesity impacts the microvasculature of a var…