Jeong‐Hun Ko
YOU?
Author Swipe
View article: Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity
Multi-tissue profiling of oxylipins reveal a conserved up-regulation of epoxide:diol ratio that associates with white adipose tissue inflammation and liver steatosis in obesity Open
View article: Multinucleation resets human macrophages for specialized functions at the expense of their identity
Multinucleation resets human macrophages for specialized functions at the expense of their identity Open
View article: Supplementary Figures 1-4 from The <i>EGFR</i> T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor
Supplementary Figures 1-4 from The <i>EGFR</i> T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor Open
PDF file - 1.9MB
View article: Data from The <i>EGFR</i> T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor
Data from The <i>EGFR</i> T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor Open
Molecular target therapies using first-generation, reversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as gefitinib or erlotinib, have been shown to be effective for patients with non-small cell lung c…
View article: Data from The <i>EGFR</i> T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor
Data from The <i>EGFR</i> T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor Open
Molecular target therapies using first-generation, reversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as gefitinib or erlotinib, have been shown to be effective for patients with non-small cell lung c…
View article: Supplementary Figures 1-4 from The <i>EGFR</i> T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor
Supplementary Figures 1-4 from The <i>EGFR</i> T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor Open
PDF file - 1.9MB
View article: BCAT1 inhibition affects CD8<sup>+</sup>T cell activation, exhaustion, and tumoral immunity by altering iron homeostasis
BCAT1 inhibition affects CD8<sup>+</sup>T cell activation, exhaustion, and tumoral immunity by altering iron homeostasis Open
The present study explores the role of the cytosolic branched chain amino acid aminotransferase (BCAT1) in CD8 + T cell activation, in general, and tumor immunity, in particular, and identifies a non-canonical function of the protein in ir…
View article: Multinucleation resets human macrophages for specialized functions at the expense of their identity
Multinucleation resets human macrophages for specialized functions at the expense of their identity Open
Macrophages undergo plasma membrane fusion and cell multinucleation to form multinucleated giant cells (MGCs) such as osteoclasts in bone, Langhans giant cells (LGCs) as part of granulomas or foreign‐body giant cells (FBGCs) in reaction to…
View article: Multinucleation resets human macrophages for specialized functions at the expense of mononuclear phagocyte identity
Multinucleation resets human macrophages for specialized functions at the expense of mononuclear phagocyte identity Open
Macrophages undergo plasma membrane fusion and cell multinucleation to form multinucleated giant cells (MGCs) such as osteoclasts in bone, Langhans giant cells (LGCs) as part of granulomas or foreign-body giant cells (FBGCs) in reaction to…
View article: Immunolipidomics Reveals a Globoside Network During the Resolution of Pro-Inflammatory Response in Human Macrophages
Immunolipidomics Reveals a Globoside Network During the Resolution of Pro-Inflammatory Response in Human Macrophages Open
Toll-like receptor 4 (TLR4)-mediated changes in macrophages reshape intracellular lipid pools to coordinate an effective innate immune response. Although this has been previously well-studied in different model systems, it remains incomple…
View article: Cardiac glycosides cause cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis
Cardiac glycosides cause cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis Open
Background and Purpose Cardiac glycosides inhibit Na + /K + ‐ATPase and are used to treat heart failure and arrhythmias. They can induce inflammasome activation and pyroptosis in macrophages, suggesting cytotoxicity, which remains to be el…
View article: Effects of Disability Acceptance of Wage Workers with Disability on Job Satisfaction - Moderated Effect of Employment Type and Mediated Effect of Inter Personal Skill
Effects of Disability Acceptance of Wage Workers with Disability on Job Satisfaction - Moderated Effect of Employment Type and Mediated Effect of Inter Personal Skill Open
View article: BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages
BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages Open
In response to environmental stimuli, macrophages change their nutrient consumption and undergo an early metabolic adaptation that progressively shapes their polarization state. During the transient, early phase of pro-inflammatory macroph…
View article: Cardiac glycosides cause selective cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis
Cardiac glycosides cause selective cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis Open
Cardiac glycosides (CGs) inhibit the Na + ,K + -ATPase and are widely prescribed medicines for chronic heart failure and cardiac arrhythmias. Recently, CGs have been described to induce inflammasome activation in human macrophages, suggest…
View article: A trans-eQTL network regulates osteoclast multinucleation and bone mass
A trans-eQTL network regulates osteoclast multinucleation and bone mass Open
Functional characterisation of cell-type-specific regulatory networks is key to establish a causal link between genetic variation and phenotype. The osteoclast offers a unique model for interrogating the contribution of co-regulated genes …
View article: Author response: A trans-eQTL network regulates osteoclast multinucleation and bone mass
Author response: A trans-eQTL network regulates osteoclast multinucleation and bone mass Open
View article: A trans-eQTL network regulates osteoclast multinucleation and bone mass
A trans-eQTL network regulates osteoclast multinucleation and bone mass Open
Functional characterisation of cell-type specific regulatory networks is key to establish a causal link between genetic variation and phenotype. The osteoclast offers a unique model for interrogating the contribution of co-regulated genes …
View article: Effects of Cultural and Artistic Experiences on Elderly Life Satisfaction : Mediating Effects of Individual Creative Traits
Effects of Cultural and Artistic Experiences on Elderly Life Satisfaction : Mediating Effects of Individual Creative Traits Open
View article: Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo
Acute Iron Deprivation Reprograms Human Macrophage Metabolism and Reduces Inflammation In Vivo Open
Iron is an essential metal that fine-tunes the innate immune response by regulating macrophage function, but an integrative view of transcriptional and metabolic responses to iron perturbation in macrophages is lacking. Here, we induced ac…
View article: Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing
Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing Open
Among other cells, macrophages regulate the inflammatory and reparative phases during wound healing but genetic determinants and detailed molecular pathways that modulate these processes are not fully elucidated. Here, we took advantage of…
View article: Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis
Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis Open
These results suggest that AA epoxygenases are essential regulators of healthy adipogenesis. Our results uncover their synergistic role in fine-tuning AA pathway in obesity-mediated hepatic steatosis.
View article: Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk
Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk Open
Our data further establish the link between macrophages and SSc, and suggest that the contribution of the rs3894194 risk variant to SSc susceptibility can be mediated by GSDMA expression in macrophages.
View article: Deferiprone, an Iron Chelator, is Preventive and Therapeutic in Experimental Crescentic Glomerulonephritis
Deferiprone, an Iron Chelator, is Preventive and Therapeutic in Experimental Crescentic Glomerulonephritis Open
Crescentic glomerulonephritis represents the most severe form of antibody-mediated glomerulonephritis. It is an important cause of renal dysfunction worldwide and there is a need for more effective treatment. Deferiprone, an orally active …
View article: BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases
BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases Open
View article: Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function
Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function Open
Crescentic glomerulonephritis (Crgn) is a complex disorder where macrophage activity and infiltration are significant effector causes. In previous linkage studies using the uniquely susceptible Wistar Kyoto (WKY) rat strain, we have identi…
View article: Genome-wide analysis of differential RNA editing in epilepsy
Genome-wide analysis of differential RNA editing in epilepsy Open
The recoding of genetic information through RNA editing contributes to proteomic diversity, but the extent and significance of RNA editing in disease is poorly understood. In particular, few studies have investigated the relationship betwe…
View article: Macrophage Epoxygenase Determines a Profibrotic Transcriptome Signature
Macrophage Epoxygenase Determines a Profibrotic Transcriptome Signature Open
Epoxygenases belong to the cytochrome P450 family. They generate epoxyeicosatrienoic acids, which are known to have anti-inflammatory effects, but little is known about their role in macrophage function. By high-throughput sequencing of RN…