Seung Yang
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View article: Sacral dimple: clinical perspectives of lesions hiddenbeneath the skin
Sacral dimple: clinical perspectives of lesions hiddenbeneath the skin Open
Sacral dimples are the most common cutaneous anomalies in newborns. While usually benign anatomical variants, some dimples are indicative of occult spinal dysraphism, such as a tethered cord, dermal sinus tract, or lipomyelomeningocele, th…
View article: Is the triptorelin stimulation test comparable to the gonadorelin stimulation test in diagnosing central precocious puberty in boys?
Is the triptorelin stimulation test comparable to the gonadorelin stimulation test in diagnosing central precocious puberty in boys? Open
View article: Management of symptoms of suspected adenomyosis uteri using herbal medicine modified Bojungikgi-tang: a case report with ultrasound monitoring
Management of symptoms of suspected adenomyosis uteri using herbal medicine modified Bojungikgi-tang: a case report with ultrasound monitoring Open
Introduction Adenomyosis is a chronic gynecological disorder characterized by the infiltration of ectopic endometrial tissue into the myometrium, affecting approximately 20–35% of women of reproductive age. Although hormonal therapy and su…
View article: MON-736 Effects of High-Dose Vitamin D Supplementation on Bone Mineral Density in Very Low Birth Weight Preterm Infants
MON-736 Effects of High-Dose Vitamin D Supplementation on Bone Mineral Density in Very Low Birth Weight Preterm Infants Open
Disclosure: M. Yoo: None. J. Seo: None. K. Lee: None. J. Choi: None. Y. Choe: None. S. Yang: None. Background: Vitamin D deficiency is highly prevalent among very low birth weight (VLBW) preterm infants owing to challenges in achieving ade…
View article: Association of obesity and adrenal androgen levels with bone age progression in boys with premature adrenarche
Association of obesity and adrenal androgen levels with bone age progression in boys with premature adrenarche Open
Purpose: Both premature adrenarche (PA) and obesity are closely linked to increases in bone age (BA). However, the mechanisms underlying these associations are unclear as research data, particularly in boys, are lacking. Therefore, our aim…
View article: Breastfeeding, Prepubertal Adiposity, and Development of Precocious Puberty
Breastfeeding, Prepubertal Adiposity, and Development of Precocious Puberty Open
Importance The incidence of central precocious puberty (CPP) is increasing globally, raising concern about its potential long-term health consequences. However, the association between early-life feeding practices and CPP is poorly underst…
View article: Real-Time Snoring Detection Using Deep Learning: A Home-Based Smartphone Approach for Sleep Monitoring
Real-Time Snoring Detection Using Deep Learning: A Home-Based Smartphone Approach for Sleep Monitoring Open
This study demonstrates the feasibility of using deep learning for real-time snoring detection from home-recorded smartphone audio. With high accuracy and scalability, the approach offers a practical and accessible tool for monitoring slee…
View article: Physical Growth Trajectories in Children With Congenital Heart Disease: A Nationwide Study
Physical Growth Trajectories in Children With Congenital Heart Disease: A Nationwide Study Open
Children with CHD showed poor growth outcomes throughout the preschool period. We highlight the importance of longitudinal growth surveillance for high-risk children with CHD during this period to mitigate the development of health issues.
View article: Cohort profile: Multicenter Networks for Ideal Outcomes of Rare Pediatric Endocrine and Metabolic Diseases in Korea (OUTSPREAD study)
Cohort profile: Multicenter Networks for Ideal Outcomes of Rare Pediatric Endocrine and Metabolic Diseases in Korea (OUTSPREAD study) Open
Rare endocrine diseases are complex conditions that require lifelong specialized care due to their chronic nature and associated long-term complications. In Korea, a lack of nationwide data on clinical practice and outcomes has limited pro…
View article: 6805 Impact of Feeding Types on Catch-Up Growth in Early Infancy Among Small-for-Gestational-Age Infants: A Nationwide Korean Study
6805 Impact of Feeding Types on Catch-Up Growth in Early Infancy Among Small-for-Gestational-Age Infants: A Nationwide Korean Study Open
Disclosure: J. Choi: None. Y. Choe: None. S. Yang: None. Purpose: The study aimed to compare growth patterns and catch-up growth (CUG) in small-for-gestational-age (SGA) infants up to age four, based on feeding type during the first 4-6 mo…
View article: Effects of the COVID-19 pandemic on serum vitamin D concentration in Korean children
Effects of the COVID-19 pandemic on serum vitamin D concentration in Korean children Open
Purpose: Social distancing policies and school closures in South Korea induced by coronavirus disease 2019 have raised concerns about a lower chance of exposure to sunlight in children and adolescents. This study investigates changes in th…
View article: Explainable Deep-Learning-Based Gait Analysis of Hip–Knee Cyclogram for the Prediction of Adolescent Idiopathic Scoliosis Progression
Explainable Deep-Learning-Based Gait Analysis of Hip–Knee Cyclogram for the Prediction of Adolescent Idiopathic Scoliosis Progression Open
Accurate prediction of scoliotic curve progression is crucial for guiding treatment decisions in adolescent idiopathic scoliosis (AIS). Traditional methods of assessing the likelihood of AIS progression are limited by variability and rely …
View article: Maternal pre-pregnancy obesity affects the uncinate fasciculus white matter tract in preterm infants
Maternal pre-pregnancy obesity affects the uncinate fasciculus white matter tract in preterm infants Open
Background A growing body of evidence suggests an association between a higher maternal pre-pregnancy body mass index (BMI) and adverse long-term neurodevelopmental outcomes for their offspring. Despite recent attention to the effects of m…
View article: The effect of finasteride on the male rat brain
The effect of finasteride on the male rat brain Open
Introduction 5AR (5-alpha reductase) inhibitors may have negative effects on psychosexual activity, but there is still debate. Objectives We aimed to observe the effect of 5-alpha reductase type 2 inhibition on the brain by using finasteri…
View article: CTNI-26. EFFICACY AND SAFETY OF METFORMIN PLUS LOW-DOSE TEMOZOLOMIDE IN PATIENTS WITH RECURRENT OR REFRACTORY GLIOBLASTOMA: A RANDOMIZED, PROSPECTIVE, MULTICENTER, DOUBLE-BLIND, CONTROLLED, PHASE 2 TRIAL
CTNI-26. EFFICACY AND SAFETY OF METFORMIN PLUS LOW-DOSE TEMOZOLOMIDE IN PATIENTS WITH RECURRENT OR REFRACTORY GLIOBLASTOMA: A RANDOMIZED, PROSPECTIVE, MULTICENTER, DOUBLE-BLIND, CONTROLLED, PHASE 2 TRIAL Open
Glioblastoma(GBM) has a poor prognosis after standard treatment. Recently, metformin has been shown to have an antitumor effect on glioma cells. We performed the first randomized prospective phase II clinical trial to investigate the clini…
View article: Monthly versus daily administration of vitamin D3 in children: a retrospective propensity score-matched study
Monthly versus daily administration of vitamin D3 in children: a retrospective propensity score-matched study Open
Objectives We aimed to evaluate the efficacy and safety of monthly vitamin D3 administration compared to a daily dosing regimen in healthy children with vitamin D deficiency. Methods This retrospective study included vitamin D deficient (s…
View article: Rapid weight gain in early life is associated with central precocious puberty in girls, not in boys - a nationwide population-based study in Korea
Rapid weight gain in early life is associated with central precocious puberty in girls, not in boys - a nationwide population-based study in Korea Open
Objectives This study aimed to investigate the effect of rapid weight gain (RWG) on the incidence of central precocious puberty (CPP) using nationwide population-based data. Methods A total of 253,967 children (101,841 boys and 152,126 gir…
View article: Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study)
Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study) Open
View article: What is the optimal prolactin cutoff for predicting the presence of a pituitary adenoma in patients with polycystic ovary syndrome?
What is the optimal prolactin cutoff for predicting the presence of a pituitary adenoma in patients with polycystic ovary syndrome? Open
Objective: Hyperprolactinemia (HPRL) and polycystic ovary syndrome (PCOS) are common causes of infertility in women of reproductive age. A pituitary adenoma (PA) is the most common type of brain tumor that causes HPRL. In the neuros…
View article: Annual Change in Fungal Concentrations and Allergic Sensitization Rates to <i>Alternaria</i> and <i>Cladosporium</i> in Korea During the Period 1998–2022
Annual Change in Fungal Concentrations and Allergic Sensitization Rates to <i>Alternaria</i> and <i>Cladosporium</i> in Korea During the Period 1998–2022 Open
The atmospheric fungal concentrations decreased annually, with allergic sensitization rate decreasing over the period of 25 years. Allergenic fungal sporulation could decrease with climate changes, such as desertification and drought. Exte…
View article: Gastric Pneumatosis and Its Gastrofibroscopic Findings in Life-Threatening Superior Mesenteric Artery Syndrome Complicated by Anorexia Nervosa in a Child
Gastric Pneumatosis and Its Gastrofibroscopic Findings in Life-Threatening Superior Mesenteric Artery Syndrome Complicated by Anorexia Nervosa in a Child Open
A 14-year-old girl was admitted to the emergency department for excessive bile-containing vomiting and severe abdominal pain. She had been healthy until she intentionally lost 25 kg over a 6-month period. Thick, bloody bile-mixed food part…
View article: A case of esophageal perforation caused by suicidal caffeine poisoning in a teenager
A case of esophageal perforation caused by suicidal caffeine poisoning in a teenager Open
Spontaneous esophageal perforation (also known as Boerhaave syndrome) is associated with sudden increase in intra-esophageal pressure by vomiting, coughing or straining at stool. This case describes a 13-year-old girl who developed the per…
View article: Lipid Accumulation Product Index Predicts New-Onset Type 2 Diabetes Among Non-Obese Koreans: A 12-Year Longitudinal Study
Lipid Accumulation Product Index Predicts New-Onset Type 2 Diabetes Among Non-Obese Koreans: A 12-Year Longitudinal Study Open
A high LAP index can be an additional indicator for new-onset T2DM among middle-aged and elderly non-obese Koreans.
View article: Simultaneous Cranioplasty vs. Staged Cranioplasty for Reconstruction of Bilateral Craniectomy
Simultaneous Cranioplasty vs. Staged Cranioplasty for Reconstruction of Bilateral Craniectomy Open
Objective: Cranioplasty (CP) following decompressive craniectomy (DC) is of low complexity surgically. However, even this “simple” procedure may have a high complication rate, especially for the reconstruction of bilateral craniectomy comp…
View article: Immune-modulatory effect of human milk in reducing the risk of Kawasaki disease: A nationwide study in Korea
Immune-modulatory effect of human milk in reducing the risk of Kawasaki disease: A nationwide study in Korea Open
Background Kawasaki disease (KD) is the most common acquired heart disease among children in developed countries, but the etiology is still unclear. There are several hypotheses regarding the outbreak of KD, including infection, genetics, …
View article: [Corrigendum] Effect of duty cycles of tumor‑treating fields on glioblastoma cells and normal brain organoids
[Corrigendum] Effect of duty cycles of tumor‑treating fields on glioblastoma cells and normal brain organoids Open
Subsequently to the publication of the above article, the authors have realized that Fig. 3 on p. 6, showing the results of bioluminescence imaging of U87 and U373 cells after applying tumor‑treating fields for 72 h, was published containi…
View article: Exertional heat stroke-related rhabdomyolysis recurring twice in a 12-year-old boy athlete
Exertional heat stroke-related rhabdomyolysis recurring twice in a 12-year-old boy athlete Open
Exertional heat stroke (EHS) is a life-threatening entity characterized by elevated core temperature with potential for multiorgan dysfunction. EHS-related rhabdomyolysis usually occurs in the early phase. We report a boy athlete with EHS-…
View article: Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma
Clinical feasibility of modified procarbazine and lomustine chemotherapy without vincristine as a salvage treatment for recurrent adult glioma Open
Procarbazine, lomustine and vincristine (PCV) chemotherapy is considered a salvage option for adult glioma; however, its significant toxicities frequently lead to dose reduction or discontinuation in patients with recurrent glioma. The cur…
View article: Effect of duty cycles of tumor-treating fields on glioblastoma cell and normal brain organoids
Effect of duty cycles of tumor-treating fields on glioblastoma cell and normal brain organoids Open
View article: Safety and efficacy of procarbazine and lomustine chemotherapy as a salvage treatment for recurrent adult glioma
Safety and efficacy of procarbazine and lomustine chemotherapy as a salvage treatment for recurrent adult glioma Open