Jeonghun Nam
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View article: Identification of Novel Biomarkers for Early Diagnosis of Atherosclerosis Using High-Resolution Metabolomics
Identification of Novel Biomarkers for Early Diagnosis of Atherosclerosis Using High-Resolution Metabolomics Open
Atherosclerosis (AS) is a metabolic disorder and the pre-stage of several cardiovascular diseases, including myocardial infarction, stroke, and angina pectoris. Early detection of AS can provide the opportunity for effective management and…
View article: Continuous On-Chip Cell Washing Using Viscoelastic Microfluidics
Continuous On-Chip Cell Washing Using Viscoelastic Microfluidics Open
Medium exchange of particles/cells to a clean buffer with a low background is essential for biological, chemical, and clinical research, which has been conventionally conducted using centrifugation. However, owing to critical limitations, …
View article: Separation and Washing of Candida Cells from White Blood Cells Using Viscoelastic Microfluidics
Separation and Washing of Candida Cells from White Blood Cells Using Viscoelastic Microfluidics Open
An early and accurate diagnosis of Candida albicans is critical for the rapid antifungal treatment of candidemia, a mortal bloodstream infection. This study demonstrates viscoelastic microfluidic techniques for continuous separation, conce…
View article: A Continuous Microfluidic Concentrator for High-Sensitivity Detection of Bacteria in Water Sources
A Continuous Microfluidic Concentrator for High-Sensitivity Detection of Bacteria in Water Sources Open
Water contamination is a critical issue that threatens global public health. To enable the rapid and precise monitoring of pathogen contamination in drinking water, a concentration technique for bacterial cells is required to address the l…
View article: Developing a multiplex loop-mediated isothermal amplification assay (LAMP) to determine severe fever with thrombocytopenia syndrome (SFTS) and scrub typhus
Developing a multiplex loop-mediated isothermal amplification assay (LAMP) to determine severe fever with thrombocytopenia syndrome (SFTS) and scrub typhus Open
Severe fever with thrombocytopenia syndrome (SFTS) and scrub typhus are endemic zoonotic diseases that pose significant public health threats in East Asia. As these two diseases share common clinical features, as well as overlapping diseas…
View article: High-Throughput Cell Concentration Using A Piezoelectric Pump in Closed-Loop Viscoelastic Microfluidics
High-Throughput Cell Concentration Using A Piezoelectric Pump in Closed-Loop Viscoelastic Microfluidics Open
Cell concentration is a critical process in biological assays and clinical diagnostics for the pre-treatment of extremely rare disease-related cells. The conventional technique for sample preconcentration and centrifugation has the limitat…
View article: An Automated Microscopic Malaria Parasite Detection System Using Digital Image Analysis
An Automated Microscopic Malaria Parasite Detection System Using Digital Image Analysis Open
Rapid diagnosis and parasitemia measurement is crucial for management of malaria. Microscopic examination of peripheral blood (PB) smears is the gold standard for malaria detection. However, this method is labor-intensive. Here, we aimed t…
View article: Development of a multiplex Loop-Mediated Isothermal Amplification (LAMP) assay for on-site diagnosis of SARS CoV-2
Development of a multiplex Loop-Mediated Isothermal Amplification (LAMP) assay for on-site diagnosis of SARS CoV-2 Open
A newly identified coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), has spread rapidly from its epicenter in China to more than 150 countries across six continents. In this study, we have designed th…
View article: Clinical Usefulness of LabChip Real-time PCR using Lab-On-a-Chip Technology for Diagnosing Malaria
Clinical Usefulness of LabChip Real-time PCR using Lab-On-a-Chip Technology for Diagnosing Malaria Open
As malaria remains a major health problem worldwide, various diagnostic tests have been developed, including microscopy-based and rapid diagnostic tests. LabChip real-time PCR (LRP) is a small and portable device used to diagnose malaria u…
View article: Development and evaluation of a multiplex loop-mediated isothermal amplification (LAMP) assay for differentiation of Mycobacterium tuberculosis and non-tuberculosis mycobacterium in clinical samples
Development and evaluation of a multiplex loop-mediated isothermal amplification (LAMP) assay for differentiation of Mycobacterium tuberculosis and non-tuberculosis mycobacterium in clinical samples Open
Introduction The rapid and accurate diagnosis of tuberculosis (TB) is important to reduce morbidity and mortality rates and risk of transmission. Therefore, molecular detection methods such as a real-time PCR–based assay for Mycobacterium …
View article: Microfluidic Devices: High‐Throughput Separation of Microvesicles from Whole Blood Components Using Viscoelastic Fluid (Adv. Mater. Technol. 12/2020)
Microfluidic Devices: High‐Throughput Separation of Microvesicles from Whole Blood Components Using Viscoelastic Fluid (Adv. Mater. Technol. 12/2020) Open
In article number 2000612, Jeonghun Nam, Chae Seung Lim, and co-workers demonstrate a sheathless, label-free, viscoelastic microfluidic device for separation of submicrometer microvesicles (MVs) from whole blood. This device enables the is…
View article: Development of a multiplex isothermal amplification molecular diagnosis method for on-site diagnosis of influenza
Development of a multiplex isothermal amplification molecular diagnosis method for on-site diagnosis of influenza Open
Influenza, which is an acute respiratory disease caused by the influenza virus, represents a worldwide public health and economic problem owing to the significant morbidity and mortality caused by its seasonal epidemics and pandemics. Sens…
View article: Sheathless Shape-Based Separation of Candida Albicans Using a Viscoelastic Non-Newtonian Fluid
Sheathless Shape-Based Separation of Candida Albicans Using a Viscoelastic Non-Newtonian Fluid Open
Rapid and accurate identification of Candida albicans from among other candida species is critical for cost-effective treatment and antifungal drug assays. Shape is a critical biomarker indicating cell type, cell cycle, and environmental c…
View article: Performance evaluation of three rapid antigen tests for the diagnosis of group A <i>Streptococci</i>
Performance evaluation of three rapid antigen tests for the diagnosis of group A <i>Streptococci</i> Open
Objective To compare the diagnostic performance of three rapid antigen detection tests (RADTs) for group A Streptococcus (GAS). Design A hospital-based, cross-sectional, retrospective study. Setting A comparative study of rapid diagnostic …
View article: Sheathless High-Throughput Circulating Tumor Cell Separation Using Viscoelastic non-Newtonian Fluid
Sheathless High-Throughput Circulating Tumor Cell Separation Using Viscoelastic non-Newtonian Fluid Open
Circulating tumor cells (CTCs) have attracted increasing attention as important biomarkers for clinical and biological applications. Several microfluidic approaches have been demonstrated to separate CTCs using immunoaffinity or size diffe…
View article: Comparative evaluation of three dengue duo rapid test kits to detect NS1, IgM, and IgG associated with acute dengue in children in Myanmar
Comparative evaluation of three dengue duo rapid test kits to detect NS1, IgM, and IgG associated with acute dengue in children in Myanmar Open
Dengue is an increasing public health concern worldwide and requires efficient laboratory diagnostics. We evaluated three commercially available dengue rapid diagnostic tests-the Humasis Dengue Combo NS1 & IgG/IgM (Humasis, Korea), SD Biol…
View article: Viscoelastic Separation and Concentration of Fungi from Blood for Highly Sensitive Molecular Diagnostics
Viscoelastic Separation and Concentration of Fungi from Blood for Highly Sensitive Molecular Diagnostics Open
Isolation and concentration of fungi in the blood improves sensitivity of the polymerase chain reaction (PCR) method to detect fungi in blood. This study demonstrates a sheathless, continuous separation and concentration method of candida …
View article: Clinical Performance of the Allplex<sup>TM</sup> Respiratory Panel 1 Test Compared to Simplexa<sup>TM</sup> Flu A/B and RSV for Detection of Influenza Virus and Respiratory Syncytial Virus Infection Including Their Subtyping
Clinical Performance of the Allplex<sup>TM</sup> Respiratory Panel 1 Test Compared to Simplexa<sup>TM</sup> Flu A/B and RSV for Detection of Influenza Virus and Respiratory Syncytial Virus Infection Including Their Subtyping Open
Objective: The AllplexTM Respiratory Panel 1 (ARP) is a new assay based on a real-time polymerase chain reaction (RT-PCR) for the detection of influenza A (Flu A), influenza B virus (Flu B), and respiratory syncytial virus (RSV), including…
View article: Determination of red blood cell deformability using centrifugal force in a three-dimensional-printed mini-disk (3D-PMD)
Determination of red blood cell deformability using centrifugal force in a three-dimensional-printed mini-disk (3D-PMD) Open
Measuring red blood cell (RBC) deformability has become important for clinical disease diagnostics. Various methods for measuring RBC deformability have been developed; however, they require costly and large instruments, long measuring tim…
View article: Continuous sheathless microparticle and cell patterning using CL-SSAWs (conductive liquid-based standing surface acoustic waves)
Continuous sheathless microparticle and cell patterning using CL-SSAWs (conductive liquid-based standing surface acoustic waves) Open
We present continuous, sheathless microparticle patterning using conductive liquid (CL)-based standing surface acoustic waves (SSAWs). Conventional metal electrodes patterned on a piezoelectric substrate were replaced with electrode channe…