Jeong‐Seok Choi
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View article: Mitomycin C Induces Autophagy in Human Tracheal Fibroblasts and Suppresses Their Growth
Mitomycin C Induces Autophagy in Human Tracheal Fibroblasts and Suppresses Their Growth Open
Objective Mitomycin C (MMC) is frequently used to prevent postoperative fibrosis in tracheal stenosis, yet its precise cellular mechanisms remain inadequately understood. This study aimed to elucidate the cytotoxic and autophagic effects o…
View article: Preventive Effect of Metformin in Radiation‐Induced Xerostomia
Preventive Effect of Metformin in Radiation‐Induced Xerostomia Open
Radiation induced structural damage of salivary gland including reducing acinar cell and fibrosis. These changes result in hypofunction of salivary gland which has a significant impact on the quality of life of head and neck cancer patient…
View article: Dynamics of Neutrophil-to-Lymphocyte Ratio (NLR), Lymphocyte-to-Monocyte Ratio (LMR), and Platelet-to-Lymphocyte Ratio (PLR) in Patients with Deep Neck Infection
Dynamics of Neutrophil-to-Lymphocyte Ratio (NLR), Lymphocyte-to-Monocyte Ratio (LMR), and Platelet-to-Lymphocyte Ratio (PLR) in Patients with Deep Neck Infection Open
Background: Inflammatory biomarkers, including the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR), have been utilized as prognostic factors in various diseases. This study a…
View article: Deep learning‐based analysis of <i>EGFR</i> mutation prevalence in lung adenocarcinoma <scp>H&E</scp> whole slide images
Deep learning‐based analysis of <i>EGFR</i> mutation prevalence in lung adenocarcinoma <span>H&E</span> whole slide images Open
EGFR mutations are a major prognostic factor in lung adenocarcinoma. However, current detection methods require sufficient samples and are costly. Deep learning is promising for mutation prediction in histopathological image analysis but h…
View article: The Analysis of Neutrophil to Lymphocyte Ratio (NLR), Lymphocyte to Monocyte Ratio (LMR), and Platelet to Lymphocyte Ratio (PLR) in Patients with Adenoidectomy and Tonsillectomy
The Analysis of Neutrophil to Lymphocyte Ratio (NLR), Lymphocyte to Monocyte Ratio (LMR), and Platelet to Lymphocyte Ratio (PLR) in Patients with Adenoidectomy and Tonsillectomy Open
Background/Objectives: Adenoidectomy and tonsillectomy are among the most commonly performed procedures in ENT practice. The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) a…
View article: Deep learning–radiomics integrated noninvasive detection of epidermal growth factor receptor mutations in non-small cell lung cancer patients
Deep learning–radiomics integrated noninvasive detection of epidermal growth factor receptor mutations in non-small cell lung cancer patients Open
View article: Supernatant of activated platelet-rich plasma rejuvenated aging-induced hyposalivation in mouse
Supernatant of activated platelet-rich plasma rejuvenated aging-induced hyposalivation in mouse Open
View article: Clinical outcome of rim-plate-augmented separate vertical wiring with supplementary fixation for the treatment of patellar fracture associated comminuted inferior pole
Clinical outcome of rim-plate-augmented separate vertical wiring with supplementary fixation for the treatment of patellar fracture associated comminuted inferior pole Open
Despite the variety of treatment methods, comminuted inferior pole fractures of the patella remain difficult and technically demanding to achieve stable internal fixation. The purpose of this study is to evaluate the clinical outcomes of r…
View article: Application of Nerve Guided Conduits for Recurrent Laryngeal Nerve Regeneration
Application of Nerve Guided Conduits for Recurrent Laryngeal Nerve Regeneration Open
Recurrent laryngeal nerve injury is a common complication of thyroid surgery that can cause communication disorders, aspiration, and swallowing difficulties.Despite extensive knowledge of the pathology and regeneration mechanisms of recurr…
View article: Adiponectin is associated with inflammaging and age-related salivary gland lipid accumulation
Adiponectin is associated with inflammaging and age-related salivary gland lipid accumulation Open
Dry mouth is frequently observed in the elderly, and enhanced lipid accumulation plays a critical role in cellular senescence in the salivary gland (SG). We investigated the mechanisms that mediate lipogenesis-associated SG senescence. Adu…
View article: A Case of Sphincter Pharyngoplasty for Persistent Velopharyngeal Insufficiency After Submucosal Cleft Palate Surgery
A Case of Sphincter Pharyngoplasty for Persistent Velopharyngeal Insufficiency After Submucosal Cleft Palate Surgery Open
Velopharyngeal insufficiency (VPI) is a phenomenon that can occur due to anatomical or neurological causes of the soft palate. VPI can make the patient difficult to articulate through hypernasality and nasal emission. There has been needed…
View article: Short-term exposure of human minor salivary gland stem cells to hypergravity enhances stemness
Short-term exposure of human minor salivary gland stem cells to hypergravity enhances stemness Open
Radiation therapy for head and neck cancer damages local stem cells and epithelial cells in salivary glands (SG), leading to irreversible SG dysfunction. Biological understanding of the responses of tissue-resident stem cells to gravity is…
View article: Efficacy of crizotinib retreatment after crizotinib-related interstitial lung disease in a patient with ROS1-rearranged advanced lung adenocarcinoma: A case report and potential crizotinib retreatment strategy
Efficacy of crizotinib retreatment after crizotinib-related interstitial lung disease in a patient with ROS1-rearranged advanced lung adenocarcinoma: A case report and potential crizotinib retreatment strategy Open
Crizotinib is an oral selective small-molecular tyrosine kinase inhibitor (TKI) that suppress the activity of anaplastic lymphoma kinase (ALK) and ROS1 kinases, as well as mesenchymal-epithelial transition. The cumulative clinical trials i…
View article: Cell-derived vesicles from adipose-derived mesenchymal stem cells ameliorate irradiation-induced salivary gland cell damage
Cell-derived vesicles from adipose-derived mesenchymal stem cells ameliorate irradiation-induced salivary gland cell damage Open
View article: Platelet-rich plasma loaded nerve guidance conduit as implantable biocompatible materials for recurrent laryngeal nerve regeneration
Platelet-rich plasma loaded nerve guidance conduit as implantable biocompatible materials for recurrent laryngeal nerve regeneration Open
Vocal cord paralysis caused by recurrent laryngeal nerve (RLN) injury during thyroidectomy results in hoarseness, aspiration, and dyspnea. We evaluated the usefulness of nerve guidance conduits (NGCs) constructed from an asymmetric polycap…
View article: Predictive Factors for the Efficacy of Voice Therapy for Pediatric Vocal Fold Nodule
Predictive Factors for the Efficacy of Voice Therapy for Pediatric Vocal Fold Nodule Open
Background and Objectives Voice therapy (VT) is considered to be the gold standard of treatment of vocal fold nodule in children. This study was designed to analyze the success rate of pediatric VT and investigate the predictive factors fo…
View article: Pediatric schwannoma of the tongue: A case report and review of literature
Pediatric schwannoma of the tongue: A case report and review of literature Open
Schwannoma of the tongue is a rare benign neoplasm in childhood. If a painless firm mass is encountered in the tongue of a child, solid tumors like schwannoma should be considered in the differential diagnosis.
View article: Sternoclavicular joint septic arthritis manifesting as deep neck infection in patients with recent acupuncture history and intra-articular injection
Sternoclavicular joint septic arthritis manifesting as deep neck infection in patients with recent acupuncture history and intra-articular injection Open
Introduction: Septic arthritis in sternoclavicular joint (SCJ) with neck abscesses is very rare. Acupuncture and intra-articular injections have been reported as a cause of septic arthritis. Patient concerns: Two patients, one with a histo…
View article: Novel Animal Model of Oral Dysphagia Following Hemiglossectomy
Novel Animal Model of Oral Dysphagia Following Hemiglossectomy Open
Min Ji Kim, M.D., Ho Minh Tri, M.D., Jeong Mi Kim, Ph.D., Mi Eun Choi, M.S., Young-Mo Kim, M.D., Ph.D., Jeong-Seok Choi, M.D., Ph.D., Ji Won Kim, M.D., Ph.D.. J Korean Dysphagia Soc 2021;11:9-14. https://doi.org/10.34160/jkds.2021.11.1.002
View article: Keratinocyte Growth Factor-1 Protects Radioiodine-Induced Salivary Gland Dysfunction in Mice
Keratinocyte Growth Factor-1 Protects Radioiodine-Induced Salivary Gland Dysfunction in Mice Open
Background: Most patients with thyroid cancer suffer from salivary gland (SG) dysfunctions after radioiodine (RI) therapy. We investigated the effects of keratinocyte growth factor (KGF)-1 on RI-induced SG dysfunction in an animal model. M…
View article: Hyaluronic Acid/Alginate Hydrogel Containing Hepatocyte Growth Factor and Promotion of Vocal Fold Wound Healing
Hyaluronic Acid/Alginate Hydrogel Containing Hepatocyte Growth Factor and Promotion of Vocal Fold Wound Healing Open
View article: Biostatistics for Multiple Testing
Biostatistics for Multiple Testing Open
Multiple testings are instances that contain simultaneous tests for more than one hypothesis. When multiple testings are conducted at the same time, it is more likely that the null hypothesis is rejected, even if the null hypothesis is cor…
View article: Effect of expanding nanocellulose sponge on nasal mucosal defects in an animal model
Effect of expanding nanocellulose sponge on nasal mucosal defects in an animal model Open
Nanocellulose has emerged for a wide range of applications in biomedical engineering because of its water absorption capacity, appropriate elasticity. We investigated the hemostatic and regenerative abilities of an expanding polyvinyl alco…
View article: Diagnostic Role of Parotid Computed Tomography for Identifying Sjögren’s Syndrome
Diagnostic Role of Parotid Computed Tomography for Identifying Sjögren’s Syndrome Open
Background and Objectives Sjögren’s syndrome (SS) is an autoimmune inflammatory disorder of exocrine glands characterized by dry mouth and eye. Recently, ultrasonography has become a valuable tool for the assessment of salivary gland invol…
View article: Identification of new genes of pleomorphic adenoma
Identification of new genes of pleomorphic adenoma Open
Pleomorphic adenoma is the most common salivary gland neoplasm with a variety of histologic appearances. Due to this diversity, precise preoperative diagnosis through fine needle aspiration cytology is difficult. This study sought to ident…
View article: Adipose-derived mesenchymal stem cells regenerate radioiodine-induced salivary gland damage in a murine model
Adipose-derived mesenchymal stem cells regenerate radioiodine-induced salivary gland damage in a murine model Open
View article: Tongue base varix as a source of oral bleeding
Tongue base varix as a source of oral bleeding Open
Rationale: Oral bleeding is usually diagnosed after by referral to other department for the differential diagnosis of hematemesis or hemoptysis. If a patient presents with blood in the oral cavity with no obvious source, generally upper ai…
View article: Fucoidan attenuates radioiodine-induced salivary gland dysfunction in mice
Fucoidan attenuates radioiodine-induced salivary gland dysfunction in mice Open
Our results demonstrate that fucoidan administration before RI treatment could attenuate RI-induced SG damage and provides a possible candidate for preventing SG damage induced by RI.
View article: Sialolith: How Big?
Sialolith: How Big? Open
View article: Parotid ductal stenosis after facial cosmetic surgery (2 case reports)
Parotid ductal stenosis after facial cosmetic surgery (2 case reports) Open
Rationale: Facial cosmetic surgery sometimes causes complications involving surrounding tissues. In particular, parotid damage may cause fibrous tissue formation, ductal stenosis, and obstruct salivary flow. Affected patients usually compl…