Jeppe Fock
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View article: IgG and IgM differentiation in a particle-based agglutination assay by control over antigen surface density
IgG and IgM differentiation in a particle-based agglutination assay by control over antigen surface density Open
Point-of-care (POC) testing offers fast and on-site diagnostics and can be crucial against many infectious diseases and in screening. One remaining challenge in serological POC testing is the quantification of immunoglobulin G (IgG) and im…
View article: Rapid Quantitative Point-Of-Care Diagnostic Test for Post COVID-19 Vaccination Antibody Monitoring
Rapid Quantitative Point-Of-Care Diagnostic Test for Post COVID-19 Vaccination Antibody Monitoring Open
Serological testing is an important diagnostic support tool in the fight against COVID-19. So far, serological testing has been performed on either lateral flow assays, which perform only qualitatively and can be difficult for the individu…
View article: Prenormative verification and validation of a protocol for measuring magnetite–maghemite ratios in magnetic nanoparticles
Prenormative verification and validation of a protocol for measuring magnetite–maghemite ratios in magnetic nanoparticles Open
An important step in establishing any new metrological method is a prenormative interlaboratory study, designed to verify and validate the method against its stated aims. Here, the 57 Fe Mössbauer spectrometric ‘centre of gravity’ (COG) me…
View article: Rapid semi-quantitative point of care diagnostic test for post vaccination antibody monitoring
Rapid semi-quantitative point of care diagnostic test for post vaccination antibody monitoring Open
Introduction Point-of-care (POC) quantification of the antibody responses against the SARS-CoV-2 Spike protein can enable decentralized monitoring of immune responses after infection or vaccination. We evaluated a novel POC microfluidic ca…
View article: Evaluation of commercially available immuno‐magnetic agglutination in comparison to enzyme‐linked immunosorbent assays for rapid point‐of‐care diagnostics of COVID‐19
Evaluation of commercially available immuno‐magnetic agglutination in comparison to enzyme‐linked immunosorbent assays for rapid point‐of‐care diagnostics of COVID‐19 Open
Introduction Coronavirus disease 2019 (COVID‐19) is caused by Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Fast, accurate, and simple blood‐based assays for quantification of anti‐SARS‐CoV‐2 antibodies are urgently needed …
View article: Revealing a masked Verwey transition in nanoparticles of coexisting Fe-oxide phases
Revealing a masked Verwey transition in nanoparticles of coexisting Fe-oxide phases Open
We provide direct evidence of a Verwey transition in a nanoparticle ensemble of mixed iron-oxide phases via temperature-dependent Raman spectroscopy.
View article: Evaluation of commercially available immuno-magnetic agglutination and enzyme-linked immunosorbent assays for rapid point-of-care diagnostics of COVID-19
Evaluation of commercially available immuno-magnetic agglutination and enzyme-linked immunosorbent assays for rapid point-of-care diagnostics of COVID-19 Open
Introduction Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory coronavirus-2 (SARS-CoV-2). Fast, accurate and simple blood-based assays for quantification of anti-SARS-CoV-2 antibodies are urgently needed to identif…
View article: CRISPR-Cas12a based internal negative control for nonspecific products of exponential rolling circle amplification
CRISPR-Cas12a based internal negative control for nonspecific products of exponential rolling circle amplification Open
False-positive results cause a major problem in nucleic acid amplification, and require external blank/negative controls for every test. However, external controls usually have a simpler and lower background compared to the test sample, re…
View article: Dipolar-coupled moment correlations in clusters of magnetic nanoparticles
Dipolar-coupled moment correlations in clusters of magnetic nanoparticles Open
Here, we investigate the nature of the moment coupling between 10-nm\nDMSA-coated magnetic nanoparticles, in both colloidal dispersion and in powder\nform. The individual iron oxide cores were composed of > 95% maghemite and\nagglomerated …
View article: Influence of clustering on the magnetic properties and hyperthermia performance of iron oxide nanoparticles
Influence of clustering on the magnetic properties and hyperthermia performance of iron oxide nanoparticles Open
Clustering of magnetic nanoparticles can drastically change their collective magnetic properties, which in turn may influence their performance in technological or biomedical applications. Here, we investigate a commercial colloidal disper…
View article: Relating Magnetic Properties and High Hyperthermia Performance of Iron Oxide Nanoflowers
Relating Magnetic Properties and High Hyperthermia Performance of Iron Oxide Nanoflowers Open
We investigated, in depth, the interrelations among structure, magnetic properties, relaxation dynamics and magnetic hyperthermia performance of magnetic nanoflowers. The nanoflowers are about 39 nm in size, and consist of densely packed i…
View article: Field-dependent dynamic responses from dilute magnetic nanoparticle dispersions
Field-dependent dynamic responses from dilute magnetic nanoparticle dispersions Open
AC susceptibility (ACS) and optomagnetic (OM) measurements vs. field and frequency allow determination of the bivariate distribution in moment and size. The obtained correlation provides information on the morphology of the magnetic nanopa…
View article: Colloidal Flower‐Shaped Iron Oxide Nanoparticles: Synthesis Strategies and Coatings
Colloidal Flower‐Shaped Iron Oxide Nanoparticles: Synthesis Strategies and Coatings Open
The assembly of magnetic cores into regular structures may notably influence the properties displayed by a magnetic colloid. Here, key synthesis parameters driving the self‐assembly process capable of organizing colloidal magnetic cores in…
View article: On the ‘centre of gravity’ method for measuring the composition of magnetite/maghemite mixtures, or the stoichiometry of magnetite-maghemite solid solutions, via<sup>57</sup>Fe Mössbauer spectroscopy
On the ‘centre of gravity’ method for measuring the composition of magnetite/maghemite mixtures, or the stoichiometry of magnetite-maghemite solid solutions, via<sup>57</sup>Fe Mössbauer spectroscopy Open
We evaluate the application of 57Fe Mössbauer spectroscopy to the determination of the
\ncomposition of magnetite (Fe3O4)/maghemite (γ-Fe2O3) mixtures and the stoichiometry
\nof magnetite-maghemite solid solutions. In particular, we consid…
View article: Optomagnetic studies of ph-switchable nanoparticle agglutination via triplex dna formation
Optomagnetic studies of ph-switchable nanoparticle agglutination via triplex dna formation Open
Polypurine-polypyrimidine sequences found in eukaryotic genomes can fold into a triple-helical structure if the sequences exhibit mirror symmetry [1]. They have been shown to stop DNA replication in vitro and in cell cultures and play a si…