Jer‐Hwa Chang
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View article: Clinical impact of pharmacogenetic risk variants in a large chinese cohort
Clinical impact of pharmacogenetic risk variants in a large chinese cohort Open
View article: ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells
ITIH4 attenuates acute lung injury by Fe-containing particulate matter in mice via Hippo pathway in type II alveolar epithelial cells Open
Background Metals in particulate matter (PM), like iron (Fe), were associated with lung injury. Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) was suggested to inhibit lung inflammation. However, the effect of metals in PM, particula…
View article: Potential Influence of ADAM9 Genetic Variants and Expression Levels on the EGFR Mutation Status and Disease Progression in Patients with Lung Adenocarcinoma
Potential Influence of ADAM9 Genetic Variants and Expression Levels on the EGFR Mutation Status and Disease Progression in Patients with Lung Adenocarcinoma Open
Lung adenocarcinoma (LUAD) is driven by epidermal growth factor receptor (EGFR) mutations, making it a key therapeutic target. ADAM9, a member of the A disintegrin and metalloproteinase (ADAM) family, facilitates the release of growth fact…
View article: The off‑target effect of loratadine triggers autophagy‑mediated apoptosis in lung adenocarcinoma cells by deactivating JNK, p38, and STAT3 signaling through both PP2A‑dependent and independent pathways
The off‑target effect of loratadine triggers autophagy‑mediated apoptosis in lung adenocarcinoma cells by deactivating JNK, p38, and STAT3 signaling through both PP2A‑dependent and independent pathways Open
Lung adenocarcinoma (LUAD) is a typical inflammation‑associated cancer, and anti‑inflammatory medications can be valuable in cancer therapy. Loratadine, a histamine receptor H1 (HRH1) antagonist, shows both anti‑inflammatory and anticancer…
View article: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort Open
Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response1. One of the most pro…
View article: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort
Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort Open
Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response 1 . One of the most promising be…
View article: Climate change, air quality, and respiratory health: a focus on particle deposition in the lungs
Climate change, air quality, and respiratory health: a focus on particle deposition in the lungs Open
This review article delves into the multifaceted relationship between climate change, air quality, and respiratory health, placing a special focus on the process of particle deposition in the lungs. We discuss the capability of climate cha…
View article: Comparison of Humoral Antibody Responses and Seroconversion Rates between Two Homologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination in Patients Undergoing Maintenance Hemodialysis
Comparison of Humoral Antibody Responses and Seroconversion Rates between Two Homologous ChAdOx1 nCoV-19 and mRNA-1273 Vaccination in Patients Undergoing Maintenance Hemodialysis Open
Background: Hemodialysis patients are at an increased risk of SARS-CoV-2 infection and are excluded from preauthorization COVID-19 vaccine trials; therefore, their immunogenicity is uncertain. Methods: To compare the antibody responses to …
View article: Role of DCLK1/Hippo Pathway in Type II Alveolar Epithelial Cells Differentiation in Acute Respiratory Distress Syndrome
Role of DCLK1/Hippo Pathway in Type II Alveolar Epithelial Cells Differentiation in Acute Respiratory Distress Syndrome Open
Background Delay in type II alveolar epithelial cell (AECII) regeneration has been linked to higher mortality in patients with acute respiratory distress syndrome (ARDS). However, the interaction between Doublecortin-like kinase 1 (DCLK1) …
View article: Supplementary Data from Circulating Proteoglycan Endocan Mediates EGFR-Driven Progression of Non–Small Cell Lung Cancer
Supplementary Data from Circulating Proteoglycan Endocan Mediates EGFR-Driven Progression of Non–Small Cell Lung Cancer Open
SUPPLEMENTARY INFORMATION Supplementary material and methods, Table S1, and Figure S1-S7 - This file contains Supplementary material and methods; Table S1. The Cox univariate and multivariate analyses of endocan and clinicopathological fac…
View article: Data from Circulating Proteoglycan Endocan Mediates EGFR-Driven Progression of Non–Small Cell Lung Cancer
Data from Circulating Proteoglycan Endocan Mediates EGFR-Driven Progression of Non–Small Cell Lung Cancer Open
Although new generations of EGFR-tyrosine kinase inhibitors (EGFR-TKI) have been developed for the treatment of patients with non–small cell lung cancer (NSCLC) with EGFR-mutant tumors, TKI resistance often returns as a result of additiona…
View article: Supplementary Data from Circulating Proteoglycan Endocan Mediates EGFR-Driven Progression of Non–Small Cell Lung Cancer
Supplementary Data from Circulating Proteoglycan Endocan Mediates EGFR-Driven Progression of Non–Small Cell Lung Cancer Open
SUPPLEMENTARY INFORMATION Supplementary material and methods, Table S1, and Figure S1-S7 - This file contains Supplementary material and methods; Table S1. The Cox univariate and multivariate analyses of endocan and clinicopathological fac…
View article: Data from Circulating Proteoglycan Endocan Mediates EGFR-Driven Progression of Non–Small Cell Lung Cancer
Data from Circulating Proteoglycan Endocan Mediates EGFR-Driven Progression of Non–Small Cell Lung Cancer Open
Although new generations of EGFR-tyrosine kinase inhibitors (EGFR-TKI) have been developed for the treatment of patients with non–small cell lung cancer (NSCLC) with EGFR-mutant tumors, TKI resistance often returns as a result of additiona…
View article: Data on lung and intestinal microbiome after air pollution exposure in ageing rats
Data on lung and intestinal microbiome after air pollution exposure in ageing rats Open
View article: COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure
COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure Open
Chronic obstructive pulmonary disease (COPD) has been linked to air pollution exposure. Air pollution has been associated with eosinophilic inflammation of respiratory disease. The objective of this study was to determine associations betw…
View article: Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer
Synergistic Tumor Inhibition via Energy Elimination by Repurposing Penfluridol and 2-Deoxy-D-Glucose in Lung Cancer Open
Energy metabolism is the basis for cell growth, and cancer cells in particular, are more energy-dependent cells because of rapid cell proliferation. Previously, we found that penfluridol, an antipsychotic drug, has the ability to trigger c…
View article: How platinum-induced nephrotoxicity occurs? Machine learning prediction in non-small cell lung cancer patients
How platinum-induced nephrotoxicity occurs? Machine learning prediction in non-small cell lung cancer patients Open
Machine learning models with clinical and genomic features can be a preliminary tool for oncologists to predict platinum-induced nephrotoxicity and provide preventive strategies in advance.
View article: The Humoral Immune Response of the ChAdOx1 nCoV-19 Vaccine in Maintenance Dialysis Patients without Prior COVID-19 Infection
The Humoral Immune Response of the ChAdOx1 nCoV-19 Vaccine in Maintenance Dialysis Patients without Prior COVID-19 Infection Open
Background: Chronic kidney disease (CKD) patients tend to have a reduced immune response to infection and vaccination. The efficacy of current available COVID-19 vaccines in CKD patients has not been widely evaluated. Methods: In the prese…
View article: Humoral Immunogenicity and Reactogenicity of the Standard ChAdOx1 nCoV-19 Vaccination in Taiwan
Humoral Immunogenicity and Reactogenicity of the Standard ChAdOx1 nCoV-19 Vaccination in Taiwan Open
Background: The ChAdOx1 nCoV-19 vaccine has been widely administered against SARS-CoV-2 infection; however, data regarding its immunogenicity, reactogenicity, and potential differences in responses among Asian populations remain scarce. Me…
View article: Associations between Ozone and Emphysema: A Systematic Review and Meta-analysis
Associations between Ozone and Emphysema: A Systematic Review and Meta-analysis Open
Air pollution is widely viewed as a serious threat to human health and a contributor to deaths. Air pollution appears to be linked to the progression of emphysema, according to epidemiological data. The objective of this study was to exami…
View article: P2‐33: Blocking MMP‐12‐modulated epithelial‐mesenchymal transition by repurposing penfluridol retsrains lung adenocarcinoma metastasis via UPA/UPAR/TGF‐Β/AKT pathway
P2‐33: Blocking MMP‐12‐modulated epithelial‐mesenchymal transition by repurposing penfluridol retsrains lung adenocarcinoma metastasis via UPA/UPAR/TGF‐Β/AKT pathway Open
prevention of either the occurrence or progression of influenza virus infection.
View article: Air Pollution-Regulated E-Cadherin Mediates Contact Inhibition of Proliferation via the Hippo Signaling Pathways in Emphysema
Air Pollution-Regulated E-Cadherin Mediates Contact Inhibition of Proliferation via the Hippo Signaling Pathways in Emphysema Open
Background: Air pollution has been linked to emphysema in chronic obstruction pulmonary disease (COPD). However, the underlying mechanisms in the development of emphysema due to air pollution remain unclear. The objective of this study was…
View article: Associations of TIMP-3 Genetic Polymorphisms with EGFR Statuses and Cancer Clinicopathologic Development in Lung Adenocarcinoma Patients
Associations of TIMP-3 Genetic Polymorphisms with EGFR Statuses and Cancer Clinicopathologic Development in Lung Adenocarcinoma Patients Open
Lung adenocarcinoma (LADC) is a major subtype of lung cancer, particularly among populations of East Asia. The epidermal growth factor receptor (EGFR) is the most frequently mutated oncogene promoting LADC progression and can serve as a th…
View article: The Curcumin Analogue, EF-24, Triggers p38 MAPK-Mediated Apoptotic Cell Death via Inducing PP2A-Modulated ERK Deactivation in Human Acute Myeloid Leukemia Cells
The Curcumin Analogue, EF-24, Triggers p38 MAPK-Mediated Apoptotic Cell Death via Inducing PP2A-Modulated ERK Deactivation in Human Acute Myeloid Leukemia Cells Open
Curcumin (CUR) has a range of therapeutic benefits against cancers, but its poor solubility and low bioavailability limit its clinical use. Demethoxycurcumin (DMC) and diphenyl difluoroketone (EF-24) are natural and synthetic curcumin anal…
View article: Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer
Discovery of clinical candidate DBPR112, a furanopyrimidine-based epidermal growth factor receptor inhibitor for the treatment of non-small cell lung cancer Open
View article: Genetic Variants of lncRNA MALAT1 Exert Diverse Impacts on the Risk and Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma
Genetic Variants of lncRNA MALAT1 Exert Diverse Impacts on the Risk and Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma Open
The long noncoding (lnc)RNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), plays a crucial role in the development of hepatocellular carcinoma (HCC). However, potential genetic variants (single nucleotide polymorphisms, …
View article: Association of <i>EGFR</i> mutations and <i>HMGB1</i> genetic polymorphisms in lung adenocarcinoma patients
Association of <i>EGFR</i> mutations and <i>HMGB1</i> genetic polymorphisms in lung adenocarcinoma patients Open
High-mobility group protein box 1 (HMGB1) is overexpressed and reported to be a prognostic factor in patients with non-small-cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) mutants play an important role in NSCLC progress…
View article: Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses
Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses Open
View article: The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance
The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance Open
View article: Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities
Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities Open
Background/Aims: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy is a clinical option for non-small cell lung cancer (NSCLC) harboring activating EGFR mutations or for cancer with wild-type (WT) EGFR when ch…