Jeremiah Nathanael Winter
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View article: ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling
ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling Open
The mammalian target of rapamycin (mTOR) is a protein kinase that, when present in a complex referred to as mTOR complex 1 (mTORC1), acts as an important regulator of growth and metabolism. The activity of the complex is regulated through …
View article: Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway
Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway Open
The mammalian target of rapamycin (mTOR) assembles into two distinct multiprotein complexes known as mTORC1 and mTORC2. Of the two complexes, mTORC1 acts to integrate a variety of positive and negative signals to downstream targets that re…