Jérémie D. Goldstein
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View article: Development of anti-murine IL-18 binding protein antibodies to stimulate IL-18 bioactivity
Development of anti-murine IL-18 binding protein antibodies to stimulate IL-18 bioactivity Open
Interleukin (IL)-18 is an immunoregulatory cytokine that acts as a potent inducer of T helper 1 and cytotoxic responses. IL-18 activity is regulated by its decoy receptor IL-18 binding protein (IL-18BP), which forms a high-affinity complex…
View article: IL-1 Family Antagonists in Mouse and Human Skin Inflammation
IL-1 Family Antagonists in Mouse and Human Skin Inflammation Open
Interleukin (IL)-1 family cytokines initiate inflammatory responses, and shape innate and adaptive immunity. They play important roles in host defense, but excessive immune activation can also lead to the development of chronic inflammator…
View article: Broadly reactive human CD4 <sup>+</sup> T cells against Enterobacteriaceae are found in the naïve repertoire and are clonally expanded in the memory repertoire
Broadly reactive human CD4 <sup>+</sup> T cells against Enterobacteriaceae are found in the naïve repertoire and are clonally expanded in the memory repertoire Open
Enterobacteriaceae are a large family of Gram‐negative bacteria that includes both commensals and opportunistic pathogens. The latter can cause severe nosocomial infections, with outbreaks of multi‐antibiotics resistant strains, thus being…
View article: Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells
Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells Open
FOXP3+ regulatory T cell (Treg) based cellular therapies represent promising therapeutic options in autoimmunity, allergy, transplantation and prevention of Graft Versus Host (GVH) Disease. Among human FOXP3-expressing CD4+T cells, only th…
View article: Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression
Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression Open
The IL-2/JAK3/STAT-5 signaling pathway is involved on the initiation and maintenance of the transcription factor Foxp3 in regulatory T cells (Treg) and has been associated with demethylation of the intronic Conserved Non Coding Sequence-2 …