Jeremy A. Leonard
YOU?
Author Swipe
View article: Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation
Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation Open
High-throughput (HT) in vitro to in vivo extrapolation (IVIVE) is an integral component in new approach method (NAM)-based risk assessment paradigms, for rapidly translating in vitro toxicity assay results into the context of in vivo expos…
View article: Environmental controls upon picophytoplankton growth and biomass in a eutrophic estuary
Environmental controls upon picophytoplankton growth and biomass in a eutrophic estuary Open
We assessed the role of top-down versus bottom-up factors in regulating picophytoplankton (PicoP) growth and overall phytoplankton size structure in a eutrophic estuary. PicoP biomass reached an annual maximum in summer/fall and was positi…
View article: PBPK model reporting template for chemical risk assessment applications
PBPK model reporting template for chemical risk assessment applications Open
Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical safety assessment. While the development of PBPK models have grown steadily sinc…
View article: Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates
Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates Open
View article: Community-Driven Metadata Standards for Agricultural Microbiome Research
Community-Driven Metadata Standards for Agricultural Microbiome Research Open
Accelerating the pace of microbiome science to enhance crop productivity and agroecosystem health will require transdisciplinary studies, comparisons among datasets, and synthetic analyses of research from diverse crop management contexts.…
View article: Tiered approaches for screening and prioritizing chemicals through integration of pharmacokinetics and exposure information with in vitro dose-response data
Tiered approaches for screening and prioritizing chemicals through integration of pharmacokinetics and exposure information with in vitro dose-response data Open
View article: A weight of evidence approach to investigate potential common mechanisms in pesticide groups to support cumulative risk assessment: A case study with dinitroaniline pesticides
A weight of evidence approach to investigate potential common mechanisms in pesticide groups to support cumulative risk assessment: A case study with dinitroaniline pesticides Open
View article: A proposal for creating a taxonomy of chemical interactions using concepts from the aggregate exposure and adverse outcome pathways
A proposal for creating a taxonomy of chemical interactions using concepts from the aggregate exposure and adverse outcome pathways Open
View article: Supporting systems science through in silico applications: A focus on informing metabolic mechanisms
Supporting systems science through in silico applications: A focus on informing metabolic mechanisms Open
View article: Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making
Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making Open
View article: Aggregate exposure pathways in support of risk assessment
Aggregate exposure pathways in support of risk assessment Open
View article: Corrigendum to “Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making”
Corrigendum to “Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making” Open
View article: Physiological Concentration of Prostaglandin E2 Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway
Physiological Concentration of Prostaglandin E2 Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway Open
View article: Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making
Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making Open
The development and application of physiologically based pharmacokinetic (PBPK) models in chemical toxicology have grown steadily since their emergence in the 1980s. However, critical evaluation of PBPK models to support public health deci…
View article: Refining the aggregate exposure pathway
Refining the aggregate exposure pathway Open
The elements of the aggregate exposure pathway have been refined to better facilitate organization, integration, and dissemination of exposure data.
View article: A workflow for identifying metabolically active chemicals to complement in vitro toxicity screening
A workflow for identifying metabolically active chemicals to complement in vitro toxicity screening Open
View article: Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications
Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications Open
Physiologically based kinetic (PBK) models are used widely throughout a number of working sectors, including academia and industry, to provide insight into the dosimetry related to observed adverse health effects in humans and other specie…
View article: Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates
Using exposure prediction tools to link exposure and dosimetry for risk-based decisions: A case study with phthalates Open
A few different exposure prediction tools were evaluated for use in the new in vitro-based safety assessment paradigm using di-2-ethylhexyl phthalate (DEHP) and dibutyl phthalate (DnBP) as case compounds. Daily intake of each phthalate was…
View article: Expanding on Successful Concepts, Models, and Organization
Expanding on Successful Concepts, Models, and Organization Open
ADVERTISEMENT RETURN TO ISSUEPREVLetter to the EditorNEXTExpanding on Successful Concepts, Models, and OrganizationJustin G. Teeguarden*†‡, Yu-Mei Tan∥, Stephen W. Edwards⊥, Jeremy A. Leonard#, Kim A. Anderson‡, Richard A. Corley‡†, Molly …
View article: Assessing toxicity of contaminants in riverine suspended sediments to freshwater mussels
Assessing toxicity of contaminants in riverine suspended sediments to freshwater mussels Open
The Clinch River in Virginia and Tennessee, USA, is well known for its diverse native freshwater mussel assemblages; however, notable declines in mussel populations in recent decades have prompted much concern and subsequent research. The …
View article: Evaluating the Impact of Uncertainties in Clearance and Exposure When Prioritizing Chemicals Screened in High-Throughput Assays
Evaluating the Impact of Uncertainties in Clearance and Exposure When Prioritizing Chemicals Screened in High-Throughput Assays Open
The toxicity-testing paradigm has evolved to include high-throughput (HT) methods for addressing the increasing need to screen hundreds to thousands of chemicals rapidly. Approaches that involve in vitro screening assays, in silico predict…
View article: Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction
Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction Open
Developing physiologically-based pharmacokinetic (PBPK) models for chemicals can be resource-intensive, as neither chemical-specific parameters nor in vivo pharmacokinetic data are easily available for model construction. Previously develo…
View article: Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-Throughput<i>in vitro</i>Data, High-Throughput Exposure Modeling, and Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling
Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-Throughput<i>in vitro</i>Data, High-Throughput Exposure Modeling, and Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Open
Some pharmaceuticals and environmental chemicals bind the thyroid peroxidase (TPO) enzyme and disrupt thyroid hormone production. The potential for TPO inhibition is a function of both the binding affinity and concentration of the chemical…
View article: Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework
Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework Open
Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of obs…
View article: A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput <i>in Vitro</i> Chemical Screening Based on Adverse Outcome Pathways
A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput <i>in Vitro</i> Chemical Screening Based on Adverse Outcome Pathways Open
Phillips MB, Leonard JA, Grulke CM, Chang DT, Edwards SW, Brooks R, Goldsmith MR, El-Masri H, Tan YM. 2016. A workflow to investigate exposure and pharmacokinetic influences on high-throughput in vitro chemical screening based on adverse o…