Jeremy Bakelar
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View article: Proceedings of the 2023 Global Polytechnic Summit, Technology Talent: Advancing a Comprehensive and Global Strategy
Proceedings of the 2023 Global Polytechnic Summit, Technology Talent: Advancing a Comprehensive and Global Strategy Open
alike.Moreover, they will forever stand as a testament to the remarkable collaboration and intellectual camaraderie fostered by the 2023 Global Polytechnic Summit.Once again, I extend my sincere thanks to all the contributors, participants,
View article: Binding Interactions of (R)- and (S)-hydroxypropyl-CoM Dehydrogenases and the Zinc Knuckle Proteins Air1 and Air2
Binding Interactions of (R)- and (S)-hydroxypropyl-CoM Dehydrogenases and the Zinc Knuckle Proteins Air1 and Air2 Open
This work is focused on understanding protein function by describing how paralogous proteins with overlapping and distinct functions interact with their substrates and with other proteins. Two model systems are the subject of this research…
View article: The β-barrel assembly machinery in motion
The β-barrel assembly machinery in motion Open
Beta-barrel outer membrane proteins (OMPs) are found within the outer membranes (OM) of Gram-negative bacteria and are essential for nutrient import, signaling, and adhesion.While the
View article: C-terminal kink formation is required for lateral gating in BamA
C-terminal kink formation is required for lateral gating in BamA Open
Significance Nearly all outer-membrane proteins (OMPs) in Gram-negative bacteria are inserted via the -barrel assembly machinery (BAM) complex. Molecular dynamics simulations have revealed a persistent C-terminal strand kink of the core …
View article: Structural and functional studies of the β-barrel assembly machinery
Structural and functional studies of the β-barrel assembly machinery Open
-barrel outer membrane proteins (OMPs) are found within the outer membranes (OM) of Gramnegative bacteria and serve critical functions including nutrient import, cell signaling, and protection.In the final stage of their biogenesis, nasce…
View article: The β-barrel assembly machinery in motion
The β-barrel assembly machinery in motion Open
Beta-barrel outer membrane proteins (OMPs) are found within the outer membranes (OM) of Gramnegative bacteria and are essential for nutrient import, signaling, and adhesion.While the exact mechanism for the biogenesis of these OMPs is unkn…
View article: Structural snapshots of the β‐barrel assembly machinery
Structural snapshots of the β‐barrel assembly machinery Open
The β‐barrel assembly machinery ( BAM ) is a multicomponent complex responsible for the biogenesis of β‐barrel outer membrane proteins ( OMP s) in Gram‐negative bacteria, with conserved systems in both mitochondria and chloroplasts. Given …
View article: The structure of the β-barrel assembly machinery complex
The structure of the β-barrel assembly machinery complex Open
Going in with a BAM Integral membrane proteins in bacterial outer membranes play roles in nutrient import and infectivity. These proteins are folded into a barrel shape composed of β-strands and inserted into the outer membrane by the β-ba…
View article: Interaction between the RNA-dependent ATPase and poly(A) polymerase subunits of the TRAMP complex is mediated by short peptides and important for snoRNA processing
Interaction between the RNA-dependent ATPase and poly(A) polymerase subunits of the TRAMP complex is mediated by short peptides and important for snoRNA processing Open
The RNA exosome is one of the main 3′ to 5′ exoribonucleases in eukaryotic cells. Although it is responsible for degradation or processing of a wide variety of substrate RNAs, it is very specific and distinguishes between substrate and non…