Jeremy Baldwin
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View article: Restoring the supply lines: removing roadblocks to fatty acid uptake enhances T cell-driven cancer fight
Restoring the supply lines: removing roadblocks to fatty acid uptake enhances T cell-driven cancer fight Open
View article: Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy Open
Mitochondrial loss and dysfunction drive T cell exhaustion, representing major barriers to successful T cell-based immunotherapies. Here, we describe an innovative platform to supply exogenous mitochondria to T cells, overcoming these limi…
View article: LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling
LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling Open
High frequencies of stem-like memory T cells in infusion products correlate with superior patient outcomes across multiple T cell therapy trials. Herein, we analyzed a published CRISPR activation screening to identify transcriptional regul…
View article: Game changers in science and technology - now and beyond
Game changers in science and technology - now and beyond Open
View article: Covax-19/Spikogen® vaccine based on recombinant spike protein extracellular domain with Advax-CpG55.2 adjuvant provides single dose protection against SARS-CoV-2 infection in hamsters
Covax-19/Spikogen® vaccine based on recombinant spike protein extracellular domain with Advax-CpG55.2 adjuvant provides single dose protection against SARS-CoV-2 infection in hamsters Open
View article: An Advax-Adjuvanted Inactivated Cell-Culture Derived Japanese Encephalitis Vaccine Induces Broadly Neutralising Anti-Flavivirus Antibodies, Robust Cellular Immunity and Provides Single Dose Protection
An Advax-Adjuvanted Inactivated Cell-Culture Derived Japanese Encephalitis Vaccine Induces Broadly Neutralising Anti-Flavivirus Antibodies, Robust Cellular Immunity and Provides Single Dose Protection Open
ccJE+Advax is an inactivated cell culture Japanese encephalitis (JE) vaccine formulated with Advax, a novel polysaccharide adjuvant based on delta inulin. This vaccine has previously shown promise in murine and equine studies and the curre…
View article: Rapid Development of Analytical Methods for Evaluating Pandemic Vaccines: A Covid-19 Perspective
Rapid Development of Analytical Methods for Evaluating Pandemic Vaccines: A Covid-19 Perspective Open
Vaccines are key in charting a path out of the COVID-19 pandemic. However, development of new vaccines is highly dependent on availability of analytical methods for their design and evaluation. This paper highlights the challenges presente…
View article: An Advax-adjuvanted Inactivated Cell-culture Japanese Encephalitis Vaccine Induces Broadly Neutralising Anti-flavivirus Antibodies and T-cell Immunity and Provides Single Dose Protection
An Advax-adjuvanted Inactivated Cell-culture Japanese Encephalitis Vaccine Induces Broadly Neutralising Anti-flavivirus Antibodies and T-cell Immunity and Provides Single Dose Protection Open
ccJE+Advax is an inactivated cell culture Japanese encephalitis (JE) vaccine formulated with Advax™, a novel polysaccharide adjuvant based on delta inulin. This vaccine has previously shown promise in murine and equine studies and th…
View article: A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells
A humanized orthotopic tumor microenvironment alters the bone metastatic tropism of prostate cancer cells Open
Prostate cancer (PCa) is the second most commonly diagnosed cancer in men, and bone is the most frequent site of metastasis. The tumor microenvironment (TME) impacts tumor growth and metastasis, yet the role of the TME in PCa metastasis to…
View article: Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection
Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection Open
View article: Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection
Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection Open
The development of a safe and effective vaccine is a key requirement to overcoming the COVID-19 pandemic. Recombinant proteins represent the most reliable and safe vaccine approach but generally require a suitable adjuvant for robust and d…
View article: Advax-CpG Adjuvant Provides Antigen Dose-Sparing and Enhanced Immunogenicity for Inactivated Poliomyelitis Virus Vaccines
Advax-CpG Adjuvant Provides Antigen Dose-Sparing and Enhanced Immunogenicity for Inactivated Poliomyelitis Virus Vaccines Open
Global immunization campaigns have resulted in a major decline in the global incidence of polio cases, with wild-type poliovirus remaining endemic in only two countries. Live oral polio vaccine (OPV) played a role in the reduction in polio…
View article: Accelerated vaccine induction of IgM neutralising antibody enables vaccine protection against same day lethal influenza virus challenge
Accelerated vaccine induction of IgM neutralising antibody enables vaccine protection against same day lethal influenza virus challenge Open
Novel influenza strains to which humans have no pre-existing immunity can trigger global pandemics without warning. Current pandemic vaccines typically require two doses and up to 6 weeks to induce protective immunity. In addition, to thei…
View article: 3D Quantification of Vascular-Like Structures in z Stack Confocal Images
3D Quantification of Vascular-Like Structures in z Stack Confocal Images Open
View article: Investigation of Sustained BMP Delivery in the Prevention of Medication‐Related Osteonecrosis of the Jaw (MRONJ) in a Rat Model
Investigation of Sustained BMP Delivery in the Prevention of Medication‐Related Osteonecrosis of the Jaw (MRONJ) in a Rat Model Open
Medication‐related osteonecrosis of the jaw (MRONJ) poses an ongoing challenge for clinicians and researchers. Currently, there is a lack of preventative measures available for at‐risk patients undergoing tooth extractions, especially thos…
View article: Microenvironment engineering of osteoblastic bone metastases reveals osteomimicry of patient-derived prostate cancer xenografts
Microenvironment engineering of osteoblastic bone metastases reveals osteomimicry of patient-derived prostate cancer xenografts Open
View article: Additively Manufactured Multiphasic Bone-Ligament-Bone Scaffold for Scapholunate Interosseous Ligament Reconstruction
Additively Manufactured Multiphasic Bone-Ligament-Bone Scaffold for Scapholunate Interosseous Ligament Reconstruction Open
View article: A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns
A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns Open
View article: Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma
Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma Open
View article: A Novel 3D Cultured Model for Studying Early Changes in Age‐Related Macular Degeneration
A Novel 3D Cultured Model for Studying Early Changes in Age‐Related Macular Degeneration Open
Various in vitro culture systems have been used to investigate the pathogenesis of age‐related macular degeneration (AMD). However, many still rely on oversimplified monolayer culture models. AMD is a complex disease, associated with the p…
View article: Comparison of Different Decalcification Methods Using Rat Mandibles as a Model
Comparison of Different Decalcification Methods Using Rat Mandibles as a Model Open
Selection of decalcification agents is an essential consideration when processing mineralized tissues because the integrity and immunohistochemical characteristics of the tissues may be affected. Here, we report results obtained from the d…
View article: Unravelling the Mechanisms behind Periosteal Regeneration and its Application in Bone Tissue Engineering
Unravelling the Mechanisms behind Periosteal Regeneration and its Application in Bone Tissue Engineering Open
This thesis explored the mechanisms underlying the structure and function of the periosteum in bone homeostasis and repair. The knowledge gained from these studies was then applied to the development of both a new tissue-engineered periost…
View article: Periosteum tissue engineering in an orthotopic in vivo platform
Periosteum tissue engineering in an orthotopic in vivo platform Open