Jérémy Dufloo
YOU?
Author Swipe
View article: Tradeoffs in viral fitness driven by alternative entry pathways
Tradeoffs in viral fitness driven by alternative entry pathways Open
Enveloped viruses can enter cells either through endocytosis or by direct fusion with the plasma membrane. The latter pathway often leads to syncytia formation, caused by the fusion of infected cells with neighboring receptor-bearing cells…
View article: Dipeptidase 1 is a functional receptor for a porcine coronavirus
Dipeptidase 1 is a functional receptor for a porcine coronavirus Open
View article: Identification and characterization of novel bat coronaviruses in Spain
Identification and characterization of novel bat coronaviruses in Spain Open
The zoonotic transmission of bat coronaviruses poses a threat to human health. However, the diversity of bat-borne coronaviruses remains poorly characterized in many geographical areas. Here, we recovered eight coronavirus genomes by perfo…
View article: Human cell adaptation of the swine acute diarrhea syndrome coronavirus spike protein
Human cell adaptation of the swine acute diarrhea syndrome coronavirus spike protein Open
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently identified highly pathogenic swine coronavirus. In vitro, SADS-CoV can infect cell lines from many different species, including humans, highlighting its high zoonotic poten…
View article: Dipeptidase 1 is a functional receptor for coronavirus PHEV
Dipeptidase 1 is a functional receptor for coronavirus PHEV Open
Coronaviruses of the subgenus Embecovirus include several relevant pathogens such as the human seasonal coronaviruses HKU1 and OC43, bovine coronavirus, and porcine hemagglutinating encephalomyelitis virus (PHEV), among others. While siali…
View article: Identification and characterization of novel bat coronaviruses in Spain
Identification and characterization of novel bat coronaviruses in Spain Open
The zoonotic transmission of bat coronaviruses poses a threat to human health. However, the diversity of bat-borne coronaviruses remains poorly characterized in many geographical areas. Here, we recovered six complete coronavirus genomes b…
View article: Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors
Receptor-binding proteins from animal viruses are broadly compatible with human cell entry factors Open
View article: Human cell adaptation of the swine acute diarrhea syndrome coronavirus spike protein
Human cell adaptation of the swine acute diarrhea syndrome coronavirus spike protein Open
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently identified highly pathogenic swine coronavirus. In vitro, SADS-CoV can infect cell lines from many different species, including humans, highlighting its high zoonotic poten…
View article: Temperature impacts SARS-CoV-2 spike fusogenicity and evolution
Temperature impacts SARS-CoV-2 spike fusogenicity and evolution Open
SARS-CoV-2 infects both the upper and lower respiratory tracts, which are characterized by different temperatures (33°C and 37°C, respectively). In addition, fever is a common COVID-19 symptom. SARS-CoV-2 has been shown to replicate more e…
View article: Sex- and species-associated differences in complement-mediated immunity in humans and rhesus macaques
Sex- and species-associated differences in complement-mediated immunity in humans and rhesus macaques Open
The complement system can be viewed as a “moderator” of innate immunity, “instructor” of humoral immunity, and “regulator” of adaptive immunity. While sex is known to affect humoral and cellular immune systems, its impact on complement in …
View article: Viral entry is a weak barrier to zoonosis
Viral entry is a weak barrier to zoonosis Open
Recent advances in viral metagenomics have led to the discovery of many mammalian viruses, but experimental tests to determine whether they pose a threat to humans are largely lacking. A first step for a virus to cross the species barrier …
View article: Cell type-specific adaptation of the SARS-CoV-2 spike
Cell type-specific adaptation of the SARS-CoV-2 spike Open
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can infect various human tissues and cell types, principally via interaction with its cognate receptor angiotensin-converting enzyme-2 (ACE2). However, how the virus evolves in d…
View article: Temperature impacts SARS-CoV-2 spike fusogenicity and evolution
Temperature impacts SARS-CoV-2 spike fusogenicity and evolution Open
SARS-CoV-2 infects both the upper and lower respiratory tracts, which are characterized by different temperatures (33°C and 37°C, respectively). In addition, fever is a common COVID-19 symptom. SARS-CoV-2 has been shown to replicate more e…
View article: Cell type-specific adaptation of the SARS-CoV-2 spike
Cell type-specific adaptation of the SARS-CoV-2 spike Open
SARS-CoV-2 can infect various human tissues and cell types, principally via interaction with its cognate receptor ACE2. However, how the virus evolves in different cellular environments is poorly understood. Here, we used experimental evol…
View article: Sex and species associated differences in Complement-mediated immunity in Humans and Rhesus macaques
Sex and species associated differences in Complement-mediated immunity in Humans and Rhesus macaques Open
The complement system can be viewed as a ‘moderator’ of innate immunity, ‘instructor’ of humoral immunity, and ‘regulator’ of adaptive immunity. While sex and aging are known to affect humoral and cellular immune systems, their impact on t…
View article: Complement contributes to antibody-mediated protection against repeated SHIV challenge
Complement contributes to antibody-mediated protection against repeated SHIV challenge Open
The first clinical efficacy trials of a broadly neutralizing antibody (bNAb) resulted in less benefit than expected and suggested that improvements are needed to prevent HIV infection. While considerable effort has focused on optimizing ne…
View article: Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies
Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies Open
View article: Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies
Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies Open
Convergent evolution of SARS-CoV-2 Omicron BA.2, BA.4 and BA.5 lineages has led to the emergence of several new subvariants, including BA.2.75.2, BA.4.6. and BQ.1.1. The subvariants BA.2.75.2 and BQ.1.1 are expected to become predominant i…
View article: Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2
Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2 Open
Memory B-cell and antibody responses to the SARS-CoV-2 spike protein contribute to long-term immune protection against severe COVID-19, which can also be prevented by antibody-based interventions. Here, wide SARS-CoV-2 immunoprofiling in W…
View article: Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers
Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers Open
View article: Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2
Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2 Open
Memory B-cell and antibody responses to the SARS-CoV-2 spike protein contribute to long-term immune protection against severe COVID-19, which can also be prevented by antibody-based interventions. Here, wide SARS-CoV-2 immunoprofiling in C…
View article: Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis
Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis Open
View article: Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells
Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells Open
View article: Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity
Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity Open
Given the suboptimal outcome of VRC01 antibody-mediated prevention of HIV-1 infection in its first field trial, means to improve diverse antiviral activities in vivo have renewed importance. This work revisits a loss-of-function experiment…
View article: SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation
SARS‐CoV‐2 Alpha, Beta, and Delta variants display enhanced Spike‐mediated syncytia formation Open
View article: Functional Heterogeneity of Mammalian IFITM Proteins against HIV-1
Functional Heterogeneity of Mammalian IFITM Proteins against HIV-1 Open
IFITMs are broad viral inhibitors capable of interfering with both early and late phases of the replicative cycle of many different viruses. By comparing 21 IFITM proteins issued from different animal species for their ability to inhibit H…
View article: SARS-CoV-2 Alpha, Beta and Delta variants display enhanced Spike-mediated Syncytia Formation
SARS-CoV-2 Alpha, Beta and Delta variants display enhanced Spike-mediated Syncytia Formation Open
Severe COVID-19 is characterized by lung abnormalities, including the presence of syncytial pneumocytes. Syncytia form when SARS-CoV-2 spike protein expressed on the surface of infected cells interacts with the ACE2 receptor on neighbourin…
View article: Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies
Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies Open
View article: Syncytia formation by SARS‐CoV‐2‐infected cells
Syncytia formation by SARS‐CoV‐2‐infected cells Open
View article: Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies
Asymptomatic and symptomatic SARS-CoV-2 infections elicit polyfunctional antibodies Open
A large proportion of SARS-CoV-2 infected individuals remains asymptomatic. Little is known about the extent and quality of their antiviral humoral response. Here, we analyzed antibody functions in 52 asymptomatic infected individuals, 119…